Aperçu des produits pour anti-FOSL2 (FOSL2) Anticorps

Human FOS-Like Antigen 2 (FOSL2) interaction partners

1. there was a negative correlation between miR-133a and FOSL2 expression in Hepatocellular carcinoma samples.

2. this study indicates the existence of an aberrant miR-124-3p/Fra-2 pathway that results in glioma aggressiveness

3. Data provide evidence that FOSL2 is the target gene of miR-143 and negatively correlated with its expression. Down-regulation of FOSL2 seems to be a critical step in regulation of OS properties and the expression of miR-143 can inhibit the proliferation, migration and invasion of OS by reducing the expression of FOSL2.

4. FOSL2 is a direct target of miR-597 in breast cancer cells.

5. The binding and expression of c-Fos/Fra-2 increased as a function of severity of tongue lesions, yet selective participation of c-Jun appears to promote poor differentiation and aggressive tumorigenesis.

6. FOSL2 facilitates TGF-beta1-induced migration by interaction with Smad3 in non-small cell lung cancer.FOSL2 positively regulates TGF-beta1 signalling .

7. FRA2 is a STAT5 target gene regulated by IL-2 in human CD4 T cells.

8. we show that the suppression was mediated, at least in part, by a suspension culture-driven decrease in the levels of two members of the AP1 transcription factor complex, c-Jun and Fra2

9. SOX4 is a direct target gene of FRA-2 and induces expression of HDAC8 in adult T-cell leukemia/lymphoma.

10. This study suggests that Fra-2 transgenic mice as an animal model of systemic sclerosis-associated pulmonary arterial hypertension display main characteristic features of the human disease.

11. results demonstrate the presence of a common oncogenic cascade initiated by FRA2/JUND in CCR4-expressing mature T-cell malignancies such as ATLL and CTCLs

12. FOSL2 is a critical regulator of leptin expression in adipocytes

13. Results suggest that Fra-2 protein may be more effective than ATF-2 protein in cyst formation originated from epithelial cells of dental follicles.

14. These findings reveal a novel function of Fra-2/AP-1 as a positive regulator of bone and matrix formation in mice and humans.

15. Fra-2 is overexpressed in SSc and acts as a novel downstream mediator of the profibrotic effects of TGFbeta and PDGF.

16. Fra-2 overexpression is associated with a more aggressive tumor phenotype and is probably involved in breast cancer progression in vivo.

17. aberrantly expressed Fra-2 in association with JunD may play a major role in CCR4 expression and oncogenesis in adult T-cell leukemia.

18. FRA2 and AP1 have roles in development of pulmonary fibrosis

19. Genes for Fra2, Id2, and CSF1-receptor are deregulated, regardless of whether the in anaplastic large cell lymphoma contains the t(2;5).

20. Fra-2 transgenic natural killer (NK)T cells produce unusually high amounts of interleukin (IL)-2 and IL-4, and proliferate abnormally.

Mouse (Murine) FOS-Like Antigen 2 (FOSL2) interaction partners

1. Fra-2 overexpression might impair myofibroblast functions crucial for secondary septation

2. Data show that Fos-Related Antigen-2 (Fra-2) is a key upstream regulator of forkhead box O1 (Foxo1) and interferon regulatory factor 4 (Irf4) expression and influences proliferation and differentiation of B cells at multiple stages.

3. Deletion of Fra-2 leads to increased PPARgamma2 expression and adipocyte differentiation as well as increased adipocyte apoptosis through upregulation of hypoxia-inducible factors.

4. Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolism.

5. Cytokine-mediated Fra-2 expression and stabilization is linked to regulation of myogenic progenitor cells.

6. AP-1 composed with JunD and Fra2 protein plays a primary role in enhancing the transcription level of the CD11c gene in dendritic cells

7. FOSL2 is a critical regulator of leptin expression in adipocytes

8. Identify Fra-2 as an O(2)-sensitive transcriptional regulator of inducible TGFbeta expression and position Fra-2 as an important player in reoxygenation-induced myocardial fibrosis.

9. These findings reveal a novel function of Fra-2/AP-1 as a positive regulator of bone and matrix formation in mice and humans.

10. Since transgenic overexpression of Fra-2 causes not only fibrosis but also vascular disease, Fra-2 might be an interesting novel candidate for molecular-targeted therapies for systemic sclerosis.

11. AP-1 transrepressing retinoic acid does not deplete coactivators or AP-1 monomers but may target specific Jun or Fos containing dimers

12. Fra2 is a novel transcription factor important for skeletogenesis by affecting chondrocyte differentiation

13. MEKK1 regulates Fra-2 protein stability by inducing Fra-2 ubiquitination and degradation.

14. NFATc1 negatively regulates osteoblst differentiation by regulating fra-2

15. These data identify junD proto-oncogene (JunD) and Fos-related antigen 2 (Fra-2) as the activator protein-1 (AP-1) factors responsible for the RANKL-induced upregulation of the mouse Tcirg1 gene expression.

16. Fos-related protein Fra-2 controls osteoclast survival and size

17. FRA2 and AP1 have roles in development of pulmonary fibrosis

18. Fra-2 is necessary for regulation of normal invariant natural killer (iNK)T cell development and function; loss of Fra-2 causes a 2.5-fold increase in thymic iNKT cells.

19. Fra-2 transcripion factor induces progressive peripheral vasculopathy in mice that resembles human systemic sclerosis.

Zebrafish FOS-Like Antigen 2 (FOSL2) interaction partners

1. Fos-like antigen 2 (Fosl2), potentiates the rate of myocardial accretion from the zebrafish second heart field.