Aperçu des produits pour GIGYF2 Protéines (GIGYF2)

Full name:: GRB10 Interacting GYF Protein 2 Protéines (GIGYF2)

Chez www.anticorps-enligne.fr sont 3 GRB10 Interacting GYF Protein 2 (GIGYF2) Protéines de 2 de différents fournisseurs disponibles. De plus, nous expédions GIGYF2 Anticorps (23) et et beaucoup plus de produits pour cette protéine. Un total de 30 GIGYF2 produits sont actuellement listés.

Synonymes:: 2610016F01Rik, A830080H02Rik, AI852361, AW259676, BC006835, fb57e02, GIGYF2, GYF2, im:6911549, mKIAA0642, PARK11, PERQ2, PERQ3, Tnrc15, wu:fb57e02, zgc:111944

afficher tous les protéines	Gène	GeneID	UniProt
	GIGYF2	26058	Q6Y7W6
	GIGYF2	227331	Q6Y7W8
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Human GRB10 Interacting GYF Protein 2 (GIGYF2) interaction partners

genetic analyses of indel loci in ACE (Montrer ACE Protéines), DJ-1 (Montrer PARK7 Protéines), and GIGYF2 genes, was performed to explore the potential contribution of insertion (I)/deletion (D) polymorphisms (indels) to the risk of PD in a Chinese population.
Full-length GIGYF2 coimmunoprecipitates with AGO2 (Montrer EIF2C2 Protéines) in human cells, and upon tethering to a reporter mRNA, GIGYF2 exhibits strong, dose-dependent silencing activity, involving both mRNA destabilization and translational repression.
required, this finding may shed light on the GIGYF2-associated mechanisms that lead to PD and suggests insulin (Montrer INS Protéines) dysregulation as a disease-specific mechanism for both PD and cognitive dysfunction.
Results suggest that the N56S and N457T of GIGYF2 are risk factors for Parkinson's disease in Caucasians, but not in Asians
GIGYF2 and the zinc finger protein 598 (ZNF598) are identifie (Montrer EIF4E Protéines)d as components of the 4EHP complex.
Our result indicated that SCNA, LRRK2, UCHL1 (Montrer UCHL1 Protéines), HtrA2 (Montrer HTRA2 Protéines) and GIGYF2 genes' mutations might not be a main reason for Chinese Autosomal dorminant Parkinson's disease
within the Chinese population, the c.297T>C p.Ala99Ala polymorphism of the GIGYF2 gene may be associated with an increased risk of developing Parkinson disease.
These data, together with those recently reported by other groups, suggest that GIGYF2 is unlikely to be the PARK11 gene.
No clearly pathogenic mutations are identified in GIGYF2 and ATP13A2 (Montrer ATP13A2 Protéines) in Brazilian patients with early-onset Parkinson's disease.
The results of this study did not support a role for GIGYF2 in the genetic etiology of Belgian Parkinson disease.

Mouse (Murine) GRB10 Interacting GYF Protein 2 (GIGYF2) interaction partners

Negative regulation of Grb10 (Montrer GRB10 Protéines) Interacting GIGYF2 protein on IGF-1 (Montrer IGF1 Protéines) receptor signaling pathway caused diabetic mice cognitive impairment.
Disruption of the eukaryotic translation initiation factor 4E (Montrer EIF4E Protéines) - Gigyf2 complex leads to increased translation and perinatal lethality in mice.
Primary cultured embryo fibroblasts from Gigyf2 null mice exhibit decreased IGF1 (Montrer IGF1 Protéines) signaling.
identification of proteins linked to insulin (Montrer INS Protéines)-like growth factor (IGF-I (Montrer IGF1 Protéines)) receptors by the Grb10 (Montrer GRB10 Protéines) adapter and modulate IGF-I (Montrer IGF1 Protéines) signaling

Profil protéine GIGYF2

Profil protéine

The protein encoded by this gene interacts with GRB10 and may be involved in the regulation of tyrosine kinase receptor signaling. This gene contains CAG repeats, and the encoded protein contains stretches glutamine and glutamic acid residues. Defects in this gene are a cause of Parkinson disease type 11 (PARK11). Multiple transcript variants encoding several different isoforms have been found for this gene.

Alternative names and synonyms associated with GIGYF2

GRB10 interacting GYF protein 2 (GIGYF2)
GRB10 interacting GYF protein 2 (Gigyf2)
GRB10 interacting GYF protein 2 (gigyf2)
GRB10 interacting GYF protein 2 S homeolog (gigyf2.S)

2610016F01Rik Protéine
A830080H02Rik Protéine
AI852361 Protéine
AW259676 Protéine
BC006835 Protéine
fb57e02 Protéine
GIGYF2 Protéine
GYF2 Protéine
im:6911549 Protéine
mKIAA0642 Protéine
PARK11 Protéine
PERQ2 Protéine
PERQ3 Protéine
Tnrc15 Protéine
wu:fb57e02 Protéine
zgc:111944 Protéine

Protein level used designations for GIGYF2

trinucleotide repeat containing 15 , GRB10 interacting GYF protein 2 , PERQ amino acid-rich with GYF domain-containing protein 2 , PERQ amino acid rich, with GYF domain 3 , Parkinson disease (autosomal recessive, early onset) 11 , trinucleotide repeat-containing gene 15 protein , GRB10-interacting GYF protein 2

GENE ID	SPECIES
424743	Gallus gallus
506913	Bos taurus
612838	Canis lupus familiaris
713675	Macaca mulatta
100021597	Monodelphis domestica
100064814	Equus caballus
100401755	Callithrix jacchus
100439308	Pongo abelii
100547124	Meleagris gallopavo
26058	Homo sapiens
227331	Mus musculus
561830	Danio rerio
495698	Xenopus laevis

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