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genetic analyses of indel loci in ACE, DJ-1, and GIGYF2 genes, was performed to explore the potential contribution of insertion (I)/deletion (D) polymorphisms (indels) to the risk of PD in a Chinese population.
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Full-length GIGYF2 coimmunoprecipitates with AGO2 in human cells, and upon tethering to a reporter mRNA, GIGYF2 exhibits strong, dose-dependent silencing activity, involving both mRNA destabilization and translational repression.
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required, this finding may shed light on the GIGYF2-associated mechanisms that lead to PD and suggests insulin dysregulation as a disease-specific mechanism for both PD and cognitive dysfunction.
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Results suggest that the N56S and N457T of GIGYF2 are risk factors for Parkinson's disease in Caucasians, but not in Asians
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GIGYF2 and the zinc finger protein 598 (ZNF598) are identified as components of the 4EHP complex.
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Our result indicated that SCNA, LRRK2, UCHL1, HtrA2 and GIGYF2 genes' mutations might not be a main reason for Chinese Autosomal dorminant Parkinson's disease
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within the Chinese population, the c.297T>C p.Ala99Ala polymorphism of the GIGYF2 gene may be associated with an increased risk of developing Parkinson disease.
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These data, together with those recently reported by other groups, suggest that GIGYF2 is unlikely to be the PARK11 gene.
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No clearly pathogenic mutations are identified in GIGYF2 and ATP13A2 in Brazilian patients with early-onset Parkinson's disease.
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The results of this study did not support a role for GIGYF2 in the genetic etiology of Belgian Parkinson disease.
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GIGYF2 is unlikely to play a major role in PD in Japanese patients, similar to other populations.
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our findings suggest that GIGYF2 variants are not a frequent cause of Parkinson's disease in the Spanish population, since we found no clearly segregating GIGYF2 variants
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GIGYF2 variants are not associated with Parkinson's disease in the mainland Chinese Population.
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The results of this study do not support a major role of GIGYF2 in parkinson disease.
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We identified nine novel variants in GIGYF2 gene, which might be associated with PD in the Chinese population.
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These data strongly support GIGYF2 as a PARK11 gene with a causal role in familial Parkinson disease.
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Mutations in GIGYF2 are not strongly related to the development of the Parkinson's disease in Portuguese and North American populations.
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This study suggested that reported mutations in GIGYF2 are not a common cause of Parkinson's disease in Norway and United States.
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The results of this study concluded that neither of Asn56Ser and Asn457Thr variants plays a major role in the pathogenesis of parkinson disease.
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We believe that variation in a gene other than GIGYF2 accounts for the previously reported linkage finding on chromosome 2q36-37.