Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher toutes les espèces
Afficher tous les synonymes
Sélectionnez vos espèces et l'application
anti-Mouse (Murine) Anticorps:
anti-Rat (Rattus) Anticorps:
Vous arrivez à notre recherche pré-filtrée.
Human Polyclonal HCRTR1 Primary Antibody pour IHC, IHC (p) - ABIN4341622
Schwenk, Igel, Neiman, Langen, Becker, Bjartell, Ponten, Wiklund, Grönberg, Nilsson, Uhlen: Toward next generation plasma profiling via heat-induced epitope retrieval and array-based assays. dans Molecular & cellular proteomics : MCP 2010
Silence of OX1R completely abolished the inhibitory function of orexin in attachment of THP-1 cells. Collectively, our data suggest that orexin A ameliorated endothelial dysfunction under inflammatory stimuli.
Involvement of HCRTR1 gene variation in the etiology of panic disorder/agoraphobia and related traits as well as treatment response to CBT.
Activation of orexin system facilitates anesthesia emergence and pain control.
Study provides the first demonstration that OX1R is aberrantly expressed in the inflamed mucosa of ulcerative colitis patients, both in the epithelial and immune cells.
In this study we demonstrate a new role of MRAP2 in the regulation of the orexin receptor 1 (OX1R) and identify the specific regions of MRAP2 required for the regulation of OX1R and PKR1. Importantly, like MC4R and PKRs, OX1R is predominately expressed in the brain where it regulates food intake
After sequencing all orexin receptor exons, one variation (rs2271933) in the OX1R gene and one variation (rs2653349) in the OX2R gene were found. However, no significant differences were found in either genotypic or allelic frequency distributions between the two study groups
G-protein-dependency of OX1 receptor signalling
Several single nucleotide polymorphisms (SNPs) in HCRTR2 were nominally associated with Antipsychotic-induced weight gain (AIWG) in patients of European ancestry treated with either clozapine or olanzapine. None of the SNPs in HCRTR1 were associated with AIWG.
Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation is highly unlikely to be caused by mutations in the exons of the HCRTR1 gene.
This study determined structures of OX1R bound to the OX1R-selective antagonist SB-674042 and the dual antagonist suvorexant at 2.8-A and 2.75-A resolution.
the orexinA/OX1 receptor axis has a significant pro-survival function in adrenal cells.
OX1R signaling can attenuate KOR-mediated reduction of cellular cAMP levels while enhancing KOR-mediated beta-arrestin recruitment and p38 activation.
OX1R and KOR heterodimerize, and this heterodimer associates with Galphas, leading to increased protein kinase A (PKA) signaling pathway activity, including upregulation of intracellular cAMP levels.
Results from homology and docking modeling show two alternative binding modes for orexin-A into orexin 1 receptor in concordance with what is known of G protein coupled receptors activation in general and the mutational data.
Data suggest that interaction between the nociceptin/nociceptin receptor system and the orexin/orexin receptor system in neurons of the hypothalamus positively and negatively modulate complex and integrated responses to stress. [REVIEW]
Decrease in Ox expression with normal human maturation and aging. This may contribute to changes in sleep regulation during development and with aging.
Orexin A upregulates the protein expression of OX1R and enhances the proliferation of SGC-7901 gastric cancer cells through the ERK signaling pathway.
Orexin receptor binding was strongly dependent on the extracellular Ca(2+) concentration.
No significant differences were found in the distribution of either genotypic or allelic frequencies between Alzheimer's disease cases and controls in the HCRTR1 polymorphisms.
Orexins modifiy orexin receptor gene expression and gonadotropin release from the anterior pituitary gland.
OX1R expression is associated with a strong specific immunomodulatory effect of orexin-A via OX1R and down-regulation of the pro-inflammatory cytokine production and secretion, as shown in two murine models recapitulating either the acute or chronic phase of ulcerative colitis.
Investigated the role of orexin receptors in compulsive-like alcohol drinking, found that systemic administration of the selective OX1R blocker SB-334867 reduced compulsive-like consumption. Results suggest that OX1R signaling is particularly important for promoting compulsive-like alcohol drinking, and that OX1Rs might represent a novel therapy to counteract compulsive aspects of human alcohol use disorders.
OXA and OX1R are expressed in the testis and that they may help in proliferation and development of germ cells, Leydig cells and Sertoli cells, and in the spermatogenic process and steroidogenesis.
Results thus suggest that type 1 diabetes mellitus impairs testicular steroidogenesis and glucose homeostasis through inhibition of orexin A/OX1R signaling cascade due to decreased OX1R expression in adult mice, thereby affecting germ cell survival and their proliferation in the testis.
Binding of OXA to OX1R is important for the development of the testis.
Study demonstrated that activation of the OX1 receptor in the ventrolateral periaqueductal gray of mice can initiate an endocannabinoid-CB1 receptor-mediated analgesia. Activation of the OX2 receptor in the ventrolateral periaqueductal gray was also antinociceptive but this antinociceptive effect is CB1 receptor-independent.
Elevation levels of OX1R and OX2R following experimental autoimmune encephalomyelitis induction suggest that alteration in orexinergic system may involve in pathogenesis of multiple sclerosis.
Study provides pharmacological and molecular evidence indicating, respectively, a role for OXR1 signaling in ethanol and saccharin binge-like drinking
orexin activation of OX1R in the bone locally suppresses bone formation and enhances bone resorption by lowering osseous ghrelin expression.
findings demonstrate that Hcrtr-1 modulates the reinforcing properties of cannabinoids.
The transcripts for the Orx1 and Orx2 receptors diverged in the basolateral amygdala with Orx1 increasing and Orx2 decreasing in animals that were susceptible to the chronic defeat.
more severe depressive behavior was associated with reduced hippocampal orexin expression, contrasted with increased orexin plus Orx1 receptor mRNA expression in the amygdala.
data demonstrate that hypocretin signaling acting on Hcrtr-1 in the PVN plays a crucial role in the expression of nicotine withdrawal.
Dynlt1 modulates orexin signaling by regulating OX1R
results indicate that hcrtr1 and 2 signaling oppose one another in the regulation of depression-like behaviors.
These results suggest that orexin and its receptor may play roles in traumatic brain injury, and that OX1R is induced in neurons and microglial cells after traumatic brain injury.
These data suggest that activation of the Ox1r is a necessary component of food-reinforced responding, motivation, or both in normal mice
loss of the 5-HTT function produces impaired sleep modulations by stress related to an enhanced hypocretinergic neurotransmission, as the sleep response to stress in 5-HTT-/- mutant mice could be normalized by blocking the hypocretin type 1 receptor
We measured hcrtR1 and hcrtR2 expression in the frontal cortex and pons using the RT-PCR method in murine models, in canine models and in humans.
Results describe the effects of dopamine D2 receptor deletion on hypothalamic expression of orexin, orexin receptor 1, alphaMSH, NPY and melanocortin receptors 3 and 4.
39 of 41 in: Acta Histochem. 2014 Jan;116(1) Orexin 1 receptor is expressed in the seminiferous tubules of boar testis.
Immunoreactivity (IR) for both orexins A and B (OXA and OXB), and cognate receptors (OX1R and OX2R) were identified only in the excretory striated ducts of the MSG while acinar cells were not immunoreactive.
Data demonstrated the presence of OX1R and OX2R genes and proteins in the ovary of the pig and the impact of the hormonal milieu on the expression of both receptors.
expression of OX1R and Ox2R in hypothalamus during oestrous cycle; evidence OX1R and OX2R mRNAs and proteins occur in hypothalamic structures engaged in control of reproduction; indicate dependence of OXR expression on endocrine reproductive state
findings provide the first evidence that orexin receptors 1 and 2 messenger RNAs and proteins occur in the pituitary of the pig and indicate the dependence of orexin receptor expression on the endocrine reproductive state
These data confirmed expression of orexin and its two receptors in the bovine adrenal gland.
locally synthesized in the urethroprostatic complex
first evidence for the expression of oxA and ox1R in the vestibular glands of mammalian genital tract
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B.
hypocretin receptor 1
, hypocretin receptor type 1
, hypocretin receptor-1
, orexin receptor 1
, orexin receptor type 1
, orexin receptor-1
, hypocretin (orexin) receptor 1
, orexin receptor type 1-like