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anti-Human MCHR1 Anticorps:
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Human Polyclonal MCHR1 Primary Antibody pour IHC (p) - ABIN4333149
Wojciechowski, Rafalski, Kucharski, Misztal, Maleszka, Bochtler, Maleszka: Insights into DNA hydroxymethylation in the honeybee from in-depth analyses of TET dioxygenase. dans Open biology 2014
Polymorphisms in the MCHR1 gene are associated with differences in body composition and interact with physiologic and energy-related lifestyle factors.
results suggest that MCHR1 may influence schizophrenia susceptibility, in particular among men and patients responding to conventional (nonclozapine) treatment
SLC-1 protein human mutation demonstrated important genetic susceptibility of sporadic nonsyndromic hearing loss in China.
DNA methylation at MCHR1 is allele-specific, age-dependent, body mass index-associated and affects transcription.
two loss-of-function mutants were identified in markedly underweight individuals, raising the possibility that a lean phenotype may be linked to deficient MCHR1 signaling
MCHR1 expression level was 1.6 times higher in vitiligo uninvolved skin (P < 0.05) and 2.23 times lower in involved skin (P < 0.05), when compared to healthy control skin.
data suggest that RGS2 and RGS8 differentially associate with MCHR1 and may represent two distinct modes of signaling mechanisms in vivo
Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.
MCH1 and MCH2 receptors were investigated and are different from those in SVK14 cells.
MCHR1 is expressed and functional in human skin
MCHR1 receptor expression on most cell types can trigger, in the presence of MCH, cAMP synthesis and calcium mobilization in peripheral blood mononuclear cells (PBMCs). Moreover, MCH treatment decreases the CD3-stimulated PBMC proliferation in vitro.
study demonstrates a complex interaction between melanin concentrating hormone receptor 1 and Gs protein-coupled signaling pathways
multiple antibody binding sites on melanin-concentrating hormone receptor 1 in vitiligo, including regions between amino acids 1 to 138 and 139 to 298.
Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail
a single point mutation at position 255 (T255A), which is located at the junction of intracellular loop 3 and transmembrane domain 6, reduces the MCHR1 cell surface expression level to 20% of that observed for the wild-type receptor
Association of MCHR1 alleles/haplotype detected might be related to juvenile-onset obesity, conditional on a particular genetic and/or environmental background.
Our results suggest that MIZIP might play an important role in mammalian cells by associating with tubulin and thus might provide a link between MCHR1 and tubulin functions.
study suggests that severe forms of obesity with early onset may be associated with single nucleotide polymorphisms in melanin-concentrating hormone receptor 1 (MCHR1)
Study suggest that GPR24 variants may confer susceptibility to both bipolar affective disorder and schizophrenia.
Single nucleotide polymorphisms of MCHR1 did not have effects on metabolic variables in humans.
This study demonstrated that the Neurochemical Heterogeneity Among Lateral Hypothalamic Melanin-Concentrating Hormone Neurons.
following pups retrieval, MCHR1 knockout mice display a lower level of Fos expression than wild type mice in the ventral tegmental area, and nucleus accumbens
This study showed that KO of mchr1 mice had significantly higher levels of both punished and non-punished food maintained responding.
MCH1-Rs regulate the rewarding properties of alcohol through interactions with signaling cascades in the nucleus accumbens shell.
The present work is the first study to systematically compare the effects of MCH signaling on behavioral and metabolic phenotypes.[Meta-analysis]
This study supports the use of the Mchr1-cre mouse for outlining the neuroanatomical distribution and neurochemical phenotype of MCHR1 neurons.
This study demonistrated that lack of MCH receptor provoked a ventricular size increase and beat frequency of ependymal cilia.
Mchr1 and Sstr3 are expressed and colocalized within cilia in multiple mouse brain regions, and they form heteromers.
Disruption of the melanin-concentrating hormone receptor 1 (MCH1R) affects thyroid function
The elevated basal body temperature and reduction in NREM sleep time resulting from shorter NREM episode durations observed in knockout mice suggests that central MCH(1) receptor has a role in thermoregulation and presumably stabilization of NREM sleep.
Data show that the melanin-concentrating hormone/MCH1R system is one of the players mediating behavioral and metabolic responses upon increased caloric consumption.
In melanin-concentrating hormone receptor 1 knock-out mice, long-term synaptic depression was strongly diminished in hippocampus.
The data indicate that the MCH system is involved in the regulation of PTZ and pilocarpine seizure threshold.
The gene encoding the mouse melanin-concentrating hormone receptor 1 was isolated and its structural organization and flanking regions were characterized.
metoprolol completely reversed the tachycardia seen in MCHR1(-/-) mice, suggesting an increased sympathetic tone
enhanced wheel running activities in mice lacking either MCH or its cognate receptor
In summary, the MCHr is not required for ghrelin induced feeding.
Deletion of MCH1r results in an upregulation of mesolimbic dopamine receptors and norepinephrine transporter, indicating that MCH1r may negatively modulate mesolimbic monoamine function.
Castration and testosterone treatment on the vasculature in the ventral prostate in adult rats and mice alter expression of this protein.
The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.
G protein-coupled receptor 24
, MCH receptor 1
, somatostatin receptor-like protein
, G protein coupled receptor 24
, G-protein coupled receptor 24
, Gpr24-9 protein coupled receptor
, melanin-concentrating hormone receptor subtype 1