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anti-Mouse (Murine) NPY Anticorps:
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Alpaca (Vicugna pacos) Polyclonal NPY Primary Antibody pour IEM, ICC - ABIN617905
Hogan, Terwilleger, Berman: Development of subpopulations of GABAergic neurons in cat visual cortical areas. dans Neuroreport 1993
Show all 289 Pubmed References
Human Polyclonal NPY Primary Antibody pour IHC (p), WB - ABIN3043892
Wang, Chen, Yue, Bai, Kou, Jin: Xiaoyaosan decoction regulates changes in neuropeptide y and leptin receptor in the rat arcuate nucleus after chronic immobilization stress. dans Evidence-based complementary and alternative medicine : eCAM 2012
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Human Polyclonal NPY Primary Antibody pour IF (p), IHC (p) - ABIN724475
Duan, Hao, Fan, Wang, Liu, Hao, Xu, Liu, Zhang: The role of neuropeptide Y and aquaporin 4 in the pathogenesis of intestinal dysfunction caused by traumatic brain injury. dans The Journal of surgical research 2013
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Human Monoclonal NPY Primary Antibody pour ELISA, WB - ABIN562025
Bojkowska, Hamczyk, Tsai, Riggan, Rissman: Neuropeptide Y influences acute food intake and energy status affects NPY immunoreactivity in the female musk shrew (Suncus murinus). dans Hormones and behavior 2008
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Human Polyclonal NPY Primary Antibody pour ICC, IF - ABIN4338814
Jimenez-Mateos, Arribas-Blazquez, Sanz-Rodriguez, Concannon, Olivos-Ore, Reschke, Mooney, Mooney, Lugara, Morgan, Langa, Jimenez-Pacheco, Silva, Mesuret, Boison, Miras-Portugal, Letavic, Artalejo et al.: microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus. ... dans Scientific reports 2015
Human Polyclonal NPY Primary Antibody pour ICC, IHC (fro) - ABIN153136
Reeber, Loeschel, Franklin, Sillitoe: Establishment of topographic circuit zones in the cerebellum of scrambler mutant mice. dans Frontiers in neural circuits 2013
Human Monoclonal NPY Primary Antibody pour ELISA, WB - ABIN518402
Yang, Fung, Rothwell, Tianmei, Weickert: Increased interstitial white matter neuron density in the dorsolateral prefrontal cortex of people with schizophrenia. dans Biological psychiatry 2010
The cardioprotective action of Nur77 can be ascribed to both inhibition of circulating NPY levels and to cardiomyocyte-specific modulation of NPY-NPY1R signaling to prevent cardiac remodeling.
The synthesis of neuropeptide Y (Npy) is increased in phagocytes in lungs following severe influenza virus infection.The genetic deletion of Npy specifically in phagocytes greatly improves the pathology of severe influenza virus infection, which is characterized by excessive virus replication and pulmonary inflammation.
results point to ECs as gatekeepers of hematopoietic stem and progenitor cell trafficking and identify a CD26-mediated NPY axis that has potential as a pharmacologic target to regulate hematopoietic trafficking in homeostatic and stress conditions.
In vitro inhibition of miR-103/107 causes a reduction in the number of Pomc-expressing cells and increases the proportion of Pomc progenitors differentiating into NPY neurons.
High NPY expression is associated with chronic social defeat stress.
nalysis of hypothalamic and neuroendocrine responses to HFS throughout the light-dark cycle suggests uncoupling of hypothalamic responses involving appetite-stimulating fasting-responsive hypothalamic neurons expressing agouti-related peptide (AgRP) and neuropeptide Y (Npy).
In this study we demonstrate dynamic changes in the number of calretinin- (CR) and neuropeptide Y-expressing (NPY) interneurons in the motor cortex of the familial hSOD1(G93A) ALS mouse model, suggesting their potential involvement in motor neuron circuitry defects.
Study demonstrated that Skn-1a is only expressed when neuropeptide Y (NPY) is activated in microvillar cells (MVCs). Therefore the expression of NPY is necessary for the transcription factor-mediated differentiation of olfactory MVCs.
Although acute loss of hypothalamic neurons that produce appetite-stimulating neuropeptide Y (Npy) and agouti-related peptide (Agrp) in adult mice or in mice homozygous for the anorexia (anx) mutation causes aphagia, our understanding of the factors that help maintain appetite regulatory circuitry is limited
NPY knockout mice displayed altered behaviour as well as molecular and morphological changes in amygdala and hippocampus. NPY knockout mice responded to stress with exaggerated hyperthermia, displayed impaired spatial memory, had higher hippocampal brain-derived neurotrophic factor mRNA levels and altered hippocampal synaptic plasticity, effects which were not seen in wildtype mice.
Orthopedic surgery modulates the expression of neuropeptide Y and BDNF at the spinal and hippocampal levels.
salience of the background context memory is modulated through muscarinic activation of NPY(+) hilar perforant path associated interneurons and NPY signaling in the dentate gyrus
NPY deficient mice had significantly impaired Hematopoietic stem/progenitor cell (HSPC) mobilization due to increased expression of HSPC maintenance factors by reduction of matrix metalloproteinase-9 (MMP-9) activity in bone marrow.
These results identify SK3 as a key intrinsic mediator that coordinates nutritional status with AgRP/NPY neural activities and animals' feeding behavior and energy metabolism.
The vasoconstrictive mechanism has been identified as neuropeptide Y acting on Y1 receptors.
Findings suggest that neuropeptide Y is expressed by distinct populations of neurons can modulate afferent and efferent projections of the central amygdala via presynaptic Y2 receptors located at inhibitory and excitatory synapses.
arcuate nucleus NPY neuropathway to the paraventricular nucleus and dorsomedial hypothalamus is pivotal in obesity-induced elevations in sympathetic nerve activity.
NPY promotes airway hyperresponsiveness through the induction of Rho kinase activity and phosphorylation of myosin light chain, which induces airway smooth muscle contraction.
stress alters CA1 circuit function through the impairment of endogenous NPY release, potentially contributing to heightened anxiety
Npy expression is decreased in the cingulate cortex following chronic unpredictable stress.
A variant of polymorphism rs16147 of the NPY gene is independently associated to a lower percentage of steatohepatitis and lobular inflammation in obese subjects with biopsy-proven NAFLD.
Individual differences in NPY expression may moderate the risk for disorders of mesoaccumbal function such as addictions and mood disorders.
The Michaelis constant (K M) and catalytic efficiency (k cat/K M) of TTR proteolysis toward amidated neuropeptide Y were 15.88 +/- 0.44 mum and 687 081 +/- 35 692 m (-1).s(-1), respectively. In addition, when the C-terminal sequence of TTR was made more hydrophobic, the K M and k cat/K M changed to 12.87 +/- 0.22 mum and 983 755 +/- 18 704 m (-1).s(-1), respectively.
Nominally significant associations between NPY polymorphisms and posttraumatic stress disorder (PTSD) susceptibility were found that did not withstand Bonferroni correction
Results of the current study suggest that the T allele of NPY promoter rs16147 is associated with resilience in the context of cumulative traumatic stress, particularly resilience to intrusion symptoms of Post Traumatic Stress Disorder.
NPY is expressed in the superficial laminae of the dorsal horn of the spinal cord, where it appears to mediate its antinociceptive actions via the Y1 and Y2 receptors.
Neuropeptide Y (NPY) is a pleiotropic gene implicated in stress resilience and is associated with higher levels of conscientiousness. Along with environmental factors such as stressful life events, this gene may be a factor in the neurobiology of human personality.
We found the suicide-associated gene coexpression network. The reconstructed network consisted of 104 genes. Topological analysis showed that in total, CCK, INPP1, DDC, and NPY genes are the most fundamental hubs in the network.
Data indicated that NPY plays a protective role in ER stress-induced neuronal cell death through activation of the PI3K-XBP1 pathway.
This study provided proof that SNPs within NPY is significantly associated with the susceptibility to and the prognosis of cervical vertigo.
Data suggest that up-regulation of NPY inhibits proliferation of adipose-derived stem cells while promoting adipogenesis and up-regulating expression of white adipocyte biomarkers PPARG, CEBPA, CIDEC, and RIP140. (PPARG = peroxisome proliferator activated receptor gamma; CEBPA = CCAAT/enhancer-binding protein alpha; CIDEC = cell death-inducing DFFA-like effector C; RIP140 = nuclear receptor interacting protein 1)
results are the first to demonstrate that functional NPY variation alters chronic stress-related vagal control, suggesting a potential parasympathetic role for NPY gene in stress regulation
Medium chain triglyceride nutritional supplementation increased the amount of activated ghrelin and NPY in anorexia nervosa patients.
Analysis indicates that low levels of NPY in psychogenic non-epileptic seizure patients may confer greater vulnerability to exhibit seizure-like symptoms and lower quality of life.
The rs16147 genotype affected the reduction in insulin resistance and insulin levels in response to two different hypocaloric diets in obese subjects, with a lack of response in subjects with the major allele.
We found that the NPY gene rs16147 SNP was related to the change in insulin levels, homeostasis model assessment-insulin resistance, CRP, IL-6 and waist circumference at 3 months after a hypocaloric low-fat diet.
genetic variation in NPY and NPY2R is at low frequency and thus does not make a major contribution to the obese phenotype in the general population
Genetic risk score (GRSNPY) analysis found twelve significant (P<0.05) serum NPY concentration related SNPs among alpha7 nicotinic acetylcholine receptor gene CHRNA7, insulin receptor gene INSR, leptin receptor gene LEPR, glucocorticoid receptor (GR) gene NR3C1, and NPY gene. However, after permutation test of gene score the predictive value of GRSNPY remained non-significant (P=0.078). CONCLUSIONS: Serum NPY level ...
In obese males, the rs164147 polymorphism of the NPY gene is associated with leptin, insulin level, HOMA-IR, and an increased risk of MetS and its related phenotypes, such as central obesity and hyperglycemia.
Both structural (+1128T/C) and promoter polymorphisms (-399 T/C) of Neuropeptide Y are strongly associated with type-II diabetes susceptibility in Gujarat population which at least in part, may result in higher levels of Neuropeptide Y thereby suggesting its crucial role in type-II diabetes susceptibility.
Overexpression of NPY increases sleep, whereas mutation of npy or ablation of npy-expressing neurons decreases sleep. NPY regulates sleep primarily by modulating the length of wake bouts.
NPY acts as an orexigenic factor in the zebrafish.
Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties.(
Developmental expression of zYb and zYc receptors suggests a role for neuropeptide Y (NPY) in organogenesis.
This study suggest that NYP cells of nucleus entopeduncularis and nucleus preopticus periventricularis, and related fiber systems, might be involved in processing of sex steroid-borne information.
In this study described the the lateral line presence of NPY-like immunoreactivity (IR) in of the Antarctic nototheniod fish. Differences in size and cellular composition between the two neuromasts were presen NPY immunoreactivity.
Neuropeptide Y mRNA content decreased 6 h after a meal, but increased to prefeeding levels by 24 h.
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY and insulin signaling pathways.
Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin and hypothalamic neuropeptide Y (NPY) release.
There is a strong association between putative favorable allelic variants (SNP) of neuropeptide Y, leptin, and IGF-1 genes, and residual feed intake, when animals were grazing on a high-quality, high-availability pasture.
The NPY SNP (NPY1) was associated with the prevalence of the animal being in calf 100 d after calving and 305-d milk yield in the first lactation.
NPY tended to increase serum growth hormone, which appeared to be a consequence of increased pulse amplitude. Infusion of NPY also increased CSF growth hormone-releasing hormone.
The effect of single nucleotide polymorphisms in 6 genes and their associations with production factors in beef cattle are reported.
Data show that PKA and PKC pathways are involved in the differential regulation of production of the neuropeptides (Met)enkephalin, galanin, somatostatin, NPY, and VIP.
Study shows that there is fast prenatal development of the neuropeptide Y (NPY) neuron system in the neocortex of the European wild boar, Sus scrofa. The mature NPY-ir pattern is recognizable at E110. Together, morphologies are conserved across species, but timing is not: in pig, the adult pattern largely forms prenatally.
Results show that the PP-fold is not important for recognition of peptide YY or neuropeptide Y at Y receptors.
NPY has a positive inotropic effect in isolated rat cardiac myocytes, which involves increase in Ca2+ release after activation of Y1 NPY receptor
High dietary copper appears to increase feed intake and promote weight gain by enhancing NPY concentration and NPY mRNA expression level in the hypothalamus of pigs.
Neuropeptide Y was released from the lung tissue of brain-dead pigs, and its concentration was related to the extent of neurogenic pulmonary edema
The present investigation provides results of increased vasocontractile effect of NOR and decreased enhancing effect of NPY on NOR vasoconstriction in the rabbit facial artery after carotid occlusion that is related to altered endothelium function
promoter variation associated with alcohol use during psychological stress
A 2-day fast increased NPY gene expression in the supraoptic nucleus and paraventricular nucleus.
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases.
, prepro-neuropeptide Y
, neuropeptide Yb
, pre-pro hormone
, preproneuropeptide Y, preproNPY
, neuropeptide Y
, neuropeptide Ya
, pro-neuropeptide Y preproprotein
, Pro-neuropeptide Y