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Our findings define 3-OST3A as a novel regulator of breast cancer pathogenicity, displaying tumor-suppressive or oncogenic activities in a cell- and tumor-dependent context, and demonstrate the clinical value of the HS-O-sulfotransferase 3-OST3A as a prognostic marker in HER2+ patients.
Detection of MUC1 and HS3ST2 promoter methylation status appears to be useful molecular markers for assessing the progressive state of the disease and could be helpful in discriminating breast cancer molecular subtypes. These results validate the methylation-based microarray analysis, thus trust their output in the future.
decreased in pre-eclamptic placental tissue
Genetic variants of HS3ST3A1 and HS3ST3B1 are associated with Plasmodium falciparum parasitaemia.
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta.
, heparan sulfate 3-O-sulfotransferase 3A1
, heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1
, heparan sulfate glucosamine 3-O-sulfotransferase 3A1
, heparin-glucosamine 3-O-sulfotransferase
, heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
, heparan sulfate (glucosamine) 3-O-sulfotransferase 3A
, heparan sulfate glucosamine 3-O-sulfotransferase 3B1
, heparan sulfate-glucosamine 3-sulfotransferase 3A1 L homeolog
, heparan sulfate-glucosamine 3-sulfotransferase 3A1 S homeolog