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anti-Human PAPSS2 Anticorps:
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Human Monoclonal PAPSS2 Primary Antibody pour IF, IHC (p) - ABIN563924
Wang, Li, Wang, Cheng, Guo: PAPSS2 promotes alkaline phosphates activity and mineralization of osteoblastic MC3T3-E1 cells by crosstalk and Smads signal pathways. dans PLoS ONE 2012
Human Polyclonal PAPSS2 Primary Antibody pour IHC (p), ELISA - ABIN544264
Faiyaz ul Haque, King, Krakow, Cantor, Rusiniak, Swank, Superti-Furga, Haque, Abbas, Ahmad, Ahmad, Cohn: Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse. dans Nature genetics 1998
Show all 3 Pubmed References
Cow (Bovine) Polyclonal PAPSS2 Primary Antibody pour IHC, WB - ABIN2783448
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... dans Molecular systems biology 2007
Energy-dependent scoring of docking solutions identified the interaction as specific for the PAPSS2 and SULT2A1 isoforms
In an Amish population, using expression profiling of genes within regions identified by a meta-analysis GWAS of survival to age 90, we localized PAPSS2 as a candidate gene for extended life span. These results provide novel evidence for genetic loci implicated in longevity and incorporate gene expression results from a unique population to locate positional candidates.
Silencing of SULT1A1 and PAPSS2 led to a significant decrease in aristolactam-DNA levels in both cell lines following exposure to AA-I, indicating the critical role for sulfonation in the activation of AA-I in vivo Since HK-2 cells proved relatively resistant to knockdown with siRNAs
Our results indicate that FGFR2 and PAPSS2 may play an important role in the regulation of magnesium homeostasis in children of European-American ancestry.
Results suggest that the loss of the susceptible region on chromosome 10q, which implicates PTEN, FAS and PAPSS2 may serve as genetic predictors of PSA recurrence after radical prostatectomy.
Direct in vivo evidence for the significant functional impact of mutant PAPSS2 on DHEA sulfation and androgen activation.
PAPSS2-brachyolmia includes phenotypes of the conventional clinical concept of brachyolmia, the Hobaek and Toledo types, and is associated with abnormal androgen metabolism.
Papss2 expression is reduced in articular cartilage following transforming growth factor-beta administration.
PAPSS2 is the disease gene for an autosomal recessive brachyolmia.
Unusual localisation signals of both PAPS synthase isoforms, are described.
Thirty-seven novel SNPs in the PAPSS2 gene and in two intergenic regions on chromosomes 2q33.1 and 18p11.32 were associated with exercise participation.
Transcriptional regulation of human 3'-phosphoadenosine 5'-phosphosulphate synthase 2.
Genetic variants in SULT2A1, PAPSS2, and STS do not predispose to polycystic ovary syndrome.
The results suggest that PAPSS2 might regulate osteoblast ALP activity and cell mineralization, probably through Smads signal pathways.
hypertrophic chondrocytes show a dramatic down-regulation of Papss2 mRNA expression, indicating an important role of the gene product for cartilage growth and development in the embryo
Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene.
3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 2
, ATP sulfurylase/APS kinase 2
, ATP sulfurylase/adenosine 5'-phosphosulfate kinase
, PAPS synthase 2
, PAPS synthetase 2
, SK 2
, bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
, bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2
, PAPSS 2
, sulfurylase kinase 2
, 3'-phosphoadenosine 5'-phosphosulfate synthase 2
, adenosine 5'-phosphosulfate kinase/ATP sulfurylase 2
, bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2-like