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We show here that sdc2,sdc3 and sdc4 are expressed in the zebrafish embryonic brain during the major period of axon growth. These genes show differing expression patterns in the brain which provides putative insights into their functional specificity.
Studied the association of the SDC3 polymorphism with growth traits in Chinese Jiaxian and Qinchuan cattle breeds; found three SNPs of SDC3 gene were associated with bovine body height, body length, chest circumference, and circumference of cannon bone.
High PTN and N-syndecan expression was closely associated with metastasis and poor prognosis, suggesting that they may promote tumor progression and perineural invasion in the orthotopic mouse model of pancreatic cancer.
Syndecan-3 and TFPI colocalize on the surface of endothelial-, smooth muscle-, and cancer cells
Data indicate that the extracellular and cytoplasmic domains of syndecans 1/2/3/4 are intrinsically disordered regions.
frequently expressed in pancreatic cancer and associated with perineural invasion
Syndecan-3 expression was not associated with disease progression and outcome in specific subtypes of mammary carcinoma.
SDC3 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
Syndecan-3 may directly transduce Glial cell line-derived neurotrophic factor (GDNF) family ligands (GFL) signals or serve as a coreceptor, presenting GFLs to the signaling receptor RET.
These findings indicate that SDC3 polymorphisms could contribute to the link between female hyperandrogenism and obesity and suggest a novel potential role for SDC3 as a modulator of gonadal steroid function.
Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy.
Selective induction of CXCL8 binding site on endothelial syndecan-3 in rheumatoid arthritis(RA) synovium. This site may be involved in leukocyte trafficking into RA synovial tissue.
The high expression of syndecan 3 and its localization to the smooth muscle bundles during normal labour, together with the significant reduction in prolonged labour, may indicate a role for this protein in the co-ordination of myometrial contractility.
There are ethnic differences in the SDC3 polymorphisms, and the polymorphisms are strongly associated with obesity.
Midkine, pleiotrophin (PTN), and their receptors syndecan-3 and receptor protein tyrosine phosphatase beta/zeta, were highly expressed in the striatum during developmen
Syndecan-3 was identified as a major HIV-1 attachment receptor on DCs.
syndecan TMD homodimerization and heterodimerization can be mediated by GxxxG motifs and modulated by sequence context
pleiotrophin (PTN) and syndecan-2 and -3 as direct binding partners of Y-P30.
found in 57.9% of pancreatic ductal carcinoma specimens
Data report that the bFGF, FGFR1/2 and syndecan 1-4 expressions are altered in bladder tumours.
Syndecan-3 ablation unexpectedly improves regeneration in repeatedly injured muscle and in dystrophic mice, accompanied by the persistence of sublaminar and interstitial, proliferating myoblasts
This study shows a novel role for syndecan-3 in inflammation
Syndecan-3 limits cocaine intake by modulating the effects of glial-cell-line-derived neurotrophic factor, which uses syndecan-3 as an alternative receptor.
This study showed that the melanocortin agonist Melanotan II (MTII) potently suppresses food intake and activates the hypothalamic paraventricular nuclei (PVN) in SDC-3(-/-) mice based on c-fos immunoreactivity
The Syndecan-3 interacts with Notch and is required for Notch processing by ADAM17/tumor necrosis factor-alpha-converting enzyme (TACE) and signal transduction.
Identification of the core protein carrying the Tn antigen in mouse brain: specific expression on syndecan-3.
Syndecan-3 mRNA transcripts are expressed by reactive astrocytes in the region surrounding the necrotic brain tissue, exhibiting peak levels at day 7 after cryo-injury.
syndecan-3 acts as an important modulator of synaptic plasticity that influences hippocampus-dependent memory.
Data support the hypothesis that syndecan-3 modulates melanocortin activity via facilitation of agouti-related protein.
hydrolysis is gamma-secretase dependent and modulates cytosolic signaling
Syndecan-3(-/-) mice exhibit a novel form of muscular dystrophy characterized by impaired locomotion, fibrosis, and hyperplasia of myonuclei and satellite cells, suggesting a role of syndecan-3 in muscle development
syndecan-3 has a role in the regulation of body weight and in obesity
Data show that massive cell death of cultured dorsal root ganglion (DRG) neurons from mice deficient in the N-syndecan gene as compared with wild-type controls.
The protein encoded by this gene belongs to the syndecan proteoglycan family. It may play a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. Allelic variants of this gene have been associated with obesity.
, syndecan neural type
, syndecan proteoglycan 3
, syndecan 3 (N-syndecan)
, syndecan-3 proteoglycan