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The isolation and characterization of a cDNA encoding zebrafish dermacan, a novel member of hyaluronan (HA)-binding proteoglycans, which was termed after its characteristic expression in the zebrafish dermal bones.
Data show that expression of mRNAs for aggrecan, collagen type II, and versican were significantly effected by the intervention.
Data show that biglycan, collagen type I, collagen type II, decorin, and versican were significantly affected by vibration duration, frequency, and amplitude.
Examined the production and distribution of versican and hyaluronan in intact vein rings cultured ex vivo, veins perfused ex vivo, and cultured venous adventitial and smooth muscle cells. Immunohistochemistry revealed higher levels of versican in the intima/media compared to the adventitia, and no differences in hyaluronan. In the vasa vasorum, versican and hyaluronan associated with CD34+ progenitor cells.
VCAN expression in colorectal cancer and its role in cetuximab resistance
miR-135a-5p can suppress cell progress including cell proliferation, migration, and invasion in thyroid carcinoma by targeting VCAN 3 '-UTR.
This study highlights the oncogenic role of VCAN in renal cell carcinogenesis and suggests that this gene has therapeutic and/or biomarker potential for renal cell cancer.
Interleukin-17A promotes tongue squamous cell carcinoma metastasis by activating miR-23b/versican pathway in the tumor microenvironment.
The macular dysfunction on mfERG was profound and of early onset. A heterozygous mutation in intron 7 of the VCAN gene (c.4004-1G > A) was found.
Versican V0 and V1 isoforms were upregulated in the uterine leiomyomas of symptomatic versus asymptomatic women. Abundant cleaved versican was detected in leiomyoma and myometrium, as well as in myometrial and leiomyoma cell lines. VCAN siRNA did not effect cell proliferation, apoptosis, or smooth muscle markers, but reduced ESR1 and PR-A expression.
Lumican and versican protein expression are associated with colorectal adenoma-to-carcinoma progression
Removal or knockdown of versican may be a possible therapeutic strategy for increasing deposition of insoluble elastin and stimulating repair of elastic fibers in COPD lung.
human myeloma tumors displaying CD8(+) infiltration/aggregates underwent VCAN proteolysis at a site predicted to generate a glycosaminoglycan-bereft N-terminal fragment.
versican decreases in follicular dermal papilla as an aging-associated change of human hair follicles
Data indicate that serum versican levels were significantly decreased in polycystic ovary syndrome (PCOS) patients, and that serum ADAMTS-1 (a disintegrin and metalloproteinase with thrombospondin motif-1) and versican levels were significantly and positively correlated with each other.
the G1 domain of versican can regulate the organization of pericellular hyaluronan and affect phenotype of cultured human dermal fibroblasts
Gene expression levels of three randomly selected DEGs, VCAN, COL5A1 and KCNJ16, were examined using RT-PCR in 10 ATC samples.. angiogenesis was activated by the high expression of CTHRC1, VCAN and POSTN, providing necessary nutrition for tumor cells
Results highlight an important role for versican in regulating the expression and assembly of elastin and the phenotype of leiomyosarcoma cells.
Versican localizes to the nucleus in proliferating mesenchymal cells and suggest role in mitotic spindle organization during cell division.
VCAN and VEGF were associated with survival in CRC patients with PM after CRS and HIPEC
Versican is a novel modulator of hepatic fibrosis.
versican mRNA is up-regulated much more highly (>600 fold) by long term hypoxia (5 days) than by 1 day of hypoxia.
Versican V1 overexpression induces a myofibroblast-like phenotype in cultured fibroblasts.
Targeting the hyaluronan and versican content of provisional matrices in a variety of diseases including cancer is becoming an attractive strategy for intervention. (Review)
Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs.
Loss of Versican is associated with reduced Lung Inflammatory Response.
Pelvic irradiation increases versican expression in bladder and rectum.
The data suggest that versican plays an important role in fundamental, overlapping cellular processes in lung development and infection.
Our results show that versican released from glioma promotes tumor expansion through glioma-associated microglial/macrophage TLR2 signaling and subsequent expression of MT1-MMP.
Arylsulfatase B regulates versican expression by galectin-3 and AP-1 mediated transcriptional effects.
Versican regulates the growth of leiomyosarcoma tumors.
expression of Vcan mRNA splice form proteins alters heart morphology and cellular protein profiles
These findings suggest that versican and hyaluronan synthesis may play an important role in the innate immune response to gram-negative lung infection.
Versican 3'-untranslated region (3'UTR) promotes dermal wound repair and fibroblast migration by regulating miRNA activity.
these data suggest a role for ADAMTS15 in a wide range of biological processes that are potentially mediated through the processing of versican.
faulty versican clearance due to ADAMTS5 deficiency blocks the initiation of pSmad2 signaling, which is required for excavation of endocardial cushions during aortic and pulmonary valve development.
these results demonstrate that versican V0 and V1 isoforms play important roles in HCC development and that versican mRNAs compete with endogenous RNAs in regulating miRNA functions.
Mesenchymal cells derived from keloid lesion (KL) cells continue to exhibit above-normal versican production.
Versican A subdomain plays an essential role for the interventricular septal formation by constituting the proteoglycan aggregates.
E(2) treatment increases the amount of dermal HA and versican V2 via paracrine release of EGF, which may be implicated in the pro-proliferative and anti-inflammatory effects of E(2) during photoaging.
The relationship between hyaluronan synthesis and levels of versican, fibronectin and several other extracellular matrix components in trabecular meshwork cells from the anterior segment of the eye was investigated.
This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene.
chondroitin sulfate proteoglycan 2a
, chondroitin sulfate proteoglycan 2 (versican)
, chondroitin sulfate proteoglycan core protein 2
, glial hyaluronate-binding protein
, large fibroblast proteoglycan
, versican core protein
, chondroitin sulfate proteoglycan 2
, chondroitin sulfate proteoglycan 2b
, versican proteoglycan
, PG-M core protein
, Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M)
, heart defect
, versican core protein-like