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anti-Human WISP1 Anticorps:
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Human Polyclonal WISP1 Primary Antibody pour IHC (p), ELISA - ABIN545759
Soon, Yie, Shvarts, Levine, Su, Tchou-Wong: Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation. dans The Journal of biological chemistry 2003
Show all 3 Pubmed References
Human Polyclonal WISP1 Primary Antibody pour ELISA, WB - ABIN548043
Major, Camp, Berndt, Yi, Goldenberg, Hubbert, Biechele, Gingras, Zheng, Maccoss, Angers, Moon: Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. dans Science (New York, N.Y.) 2007
Human Polyclonal WISP1 Primary Antibody pour IF (p), IHC (p) - ABIN872843
Xu, Zhao, Zhang, Xu, Yang, Wang, Liu: Resveratrol Attenuates Hyperoxia-induced Oxidative Stress, Inflammation and Fibrosis and Suppresses Wnt/?-catenin Signaling in Lungs of Neonatal Rats. dans Clinical and experimental pharmacology & physiology 2015
WISP-1 signaling upregulation may be of future benefit in cell therapy mediated bone tissue engineering.
we have demonstrated that genetic variants surrounding WISP1 are associated with bone mineral density ( at multiple skeletal sites in the Old Order Amish, thus influencing osteoporosis risk. These results support a role for the WISP1 gene on influencing variation in bone mineral density
The novel adipokine WISP1 associates with insulin resistance and impairs insulin action in human myotubes and mouse hepatocytes.
Studies showed that osteoblast-derived WISP-1 plays a key role in promoting prostate cancer (PC) interaction with bone via VCAM-1 up-regulation. Also, osteoblast-derived WISP-1 induces ET-1 expression in PCa cells, leading to integrin a4b1 production in osteoblasts favoring their adhesion with VCAM-1+ metastatic PCa cells. WISP-1 in the bone microenvironment leads to bone mineralization and inhibits osteoclastogenesis.
Study finds that genotypes AG/GG in WNT1 inducible signaling pathway protein 1 single-nucleotide polymorphisms rs2977530 reduce the susceptibility of Taiwanese women to invasive cervical cancer, whereas genotype AA in rs2977537 increases the risk.
FAT10 overexpression facilitated WISP1 degradation by FAT10ylation to decrease WISP1 protein expression, thus promoting hepatocellular carcinoma proliferation.
Results show that CCN4 is up-regulated during the inflammation period of wound repair. Also, CCN4 stimulates dermal fibroblast cell migration, proliferation and inhibits TNF-alpha stimulation, all of which could regulate wound healing.
WISP1 can be involved in glucose/lipid metabolism in obese youth, which may be modulated by IL-18. Increased WISP1 levels may be a risk factor of obesity and insulin resistance, and WISP1 has a potential therapeutic effect on insulin resistance in obese children and adolescents
The patients with higher frequencies of WISP1 rs62514004 (AG + GG) and rs16893344 (CT + TT) variants revealed a lower risk to reach a later clinical stage compared with their wild-type carriers.
Urothelial cell carcinoma carrying WISP1 rs2977530 genetic variants (AG + GG) have a higher risk of developing a more invasive tumor stage and a large tumor.
Study shows that WISP1 expression is significantly upregulated in glioblastoma tissue and cell lines. Also, WISP1 seems to be an important regulator of glioblastoma cell proliferation, apoptosis, migration, invasion, and TMZ drug resistance. WISP1 mediates these biological processes through regulating critical gene expression and pathways that are involved in cancer progression.
WISP1 has a role in colon cancer apoptosis, invasion and poor prognosis
Results indicate that SFRP1 rs7832767 C > T, CTNNB1 rs2293303 C > T, and WISP1 rs16893344 C > T were all strongly correlated with myocardial infarction (MI) susceptibility.
There is a relationship between WISP1 and the metabolic parameters of gestational diabetes (GDM). And, WISP1 might be involved in the pathophysiology of GDM.
Macrophage-derived IL-10 has a role in mediating mucosal repair by epithelial WISP-1 signaling
results demonstrate that a joint effect of WISP1 rs2929970 with smoking as well as WISP1 rs16893344 with betel nut chewing causally contributes to the occurrence of OSCC. WISP1 polymorphism may serve as a marker or a therapeutic target in OSCC
Taken together, our findings presented the first evidence that Wnt1-inducible signaling pathway protein-1 was upregulated in gastric cancer and acted as an oncogene by promoting proliferation, migration, and invasion in gastric cancer cells.
findings reveal that WISP-1 enhances VEGF-A expression and angiogenesis through the FAK/JNK/HIF-1alpha signaling pathways, as well as via down-regulation of miR-381 expression.
Akt signaling pathway mediates WISP1-induced migration and proliferation of human VSMCs
WISP1 is increased in IBD and contributes to the proinflammatory cascades in the gut.
Two paralogs of mammalian wisp1 genes were found in zebrafish.
results indicate that WISP1 present within the tumor microenvironment stimulates melanoma invasion and metastasis by promoting an EMT-like process.
WISP1 contributes to hepatic steatosis and skeletal muscle insulin resistance through a TLR4-activated inflammation/JNK signaling pathway.
noncanonical Wnt signaling participates in VILI by modulating WISP1 expression, which has been previously noted as critical for VILI development. Therefore, the noncanonical Wnt signaling pathway may provide a preventive and therapeutic target in VILI.
LncRNA FOXC2-AS1 protects cardiomyocytes from doxorubicin-induced cardiotoxicity through activation of Wisp1.
WISP1 interacts with PPARgamma and that this interaction results in the inhibition of PPARgamma activity. T
WISP1 plays an aggravating role in the development of post-traumatic experimental OA.
Data revealed that reconstituted overexpression of WISP-1 could largely reverse the Notch1-/--induced metastasis-promoting effect of mesenchymal stem cell-derived stromal fibroblasts (MSC-DF); thus, demonstrating that the Notch1-determined melanoma metastasis-regulating role of MSC-DF is mediated primarily by WISP-1.
Upregulation of Wnt2 expression enhanced WISP-1 and promoted vascular smooth muscle cell migration and intimal thickening.
One of the most striking new findings was up-regulation of mRNA for the matricellular protein WNT1-inducible signaling pathway protein 1 (CCN4) in metastatic cells; increased protein expression was verified by immunoblotting and immunocytochemistr
WISP1 might contribute to hepatic ischemia reperfusion injury in mice and possibly depends on TLR4/TRIF signaling.
CCN4 has a positive influence on chondrogenic differentiation by modulating the effects of TGF-beta3.
the Bmp3/Wisp1 signaling pathway play a key role in mesenchymal stem cell proliferation, and consequently adipogenesis.
the Wisp1-integrin beta6 pathway is inhibited by RGD peptides in septic mice, which protects against acute lung injury
WISP1 is a novel regulator of bone turnover and Wnt signaling
The data suggest that WISP1 may play a role in linking obesity to inflammation and insulin resistance and could be a novel therapeutic target for obesity.
Wnt5a-induced Wnt1-inducible secreted protein-1 suppresses vascular smooth muscle cell apoptosis induced by oxidative stress.
Notch1-induced WISP-1 expression appeared to be Wnt11-dependent, but Wnt1-independent
WISP-1 exerts paracrine action on immune cells by inhibiting their response to IL12
WISP1 is an endogenous signal that acts through TLR4 signaling to increase alveolar-capillary permeability in ventilator-induced lung injury.
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified.
CCN family member 4
, WNT1 induced secreted protein 1
, WNT1-inducible-signaling pathway protein 1
, Wnt-1 inducible signaling pathway protein 1
, Wnt-1-induced secreted protein
, WNT1 inducible signaling pathway protein 1