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anti-Human FNDC5 Anticorps:
anti-Mouse (Murine) FNDC5 Anticorps:
anti-Rat (Rattus) FNDC5 Anticorps:
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Human Polyclonal FNDC5 Primary Antibody pour IHC, IHC (p) - ABIN4327646
Komolka, Albrecht, Schering, Brenmoehl, Hoeflich, Maak: Locus characterization and gene expression of bovine FNDC5: is the myokine irisin relevant in cattle? dans PLoS ONE 2014
Human Polyclonal FNDC5 Primary Antibody pour WB - ABIN1169430
Wrann, White, Salogiannnis, Laznik-Bogoslavski, Wu, Ma, Lin, Greenberg, Spiegelman: Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. dans Cell metabolism 2013
Human Polyclonal FNDC5 Primary Antibody pour IF (p), IHC (p) - ABIN1387505
Park, Kim, Choi, Heo, Park: New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro. dans Cellular signalling 2015
Neither FNDC5 nor its putatively secreted peptide irisin were found in circulation of bulls.
irisin was significantly higher in obese than in control children, and was inversely correlated with Acrp30 and high molecular weight (HMW) oligomers; inverse correlation between Irisin and Acrp30 and, more significantly, between Irisin and HMW oligomers suggests that the two cytokines are closely connected
Irisin is an oxidative stress marker and a metabolic protective hormone.
Mild cold exposure increased vasoconstriction with a drop in in-the-ear temperature and these were related. Greater irisin was related to a greater fasting fat oxidation in the absence of shivering
Activation of the nuclear receptor constitutive androstane receptor (Montrer NR1I3 Anticorps) (CAR) induced FNDC5 mRNA expression in the liver.
HCC (Montrer FAM126A Anticorps)-liver tissue over-expressed FNDC5/Irisin in association with gene expression of mediators involved in lipogenesis, inflammation and cancer, suggesting a possible protective role of the hormone from the liver damage.
The secretion of FNDC5 from myotubes and beta-cells in response to exogenous fatty acids, the effects of recombinant FNDC5 on insulin (Montrer INS Anticorps) biosynthesis and glucose-stimulated insulin (Montrer INS Anticorps) secretion, and beta-cell apoptosis are reported.
Irisin regulates the number and function of endothelial progenitor cells via the PI3K (Montrer PIK3CA Anticorps)/Akt (Montrer AKT1 Anticorps)/eNOS (Montrer NOS3 Anticorps) pathway in mouse model of diabetes mellitus.
there is a correlation between sport performance, insulin (Montrer INS Anticorps) sensitivity, and irisin levels
results firstly revealed that irisin mitigated oxygen-glucose deprivation-induced neuronal injury in part via inhibiting ROS (Montrer ROS1 Anticorps)-NLRP3 (Montrer NLRP3 Anticorps) inflammatory signaling pathway, suggesting a likely mechanism for irisin-induced therapeutic effect in ischemic stroke.
These data indicate that increased irisin levels may have protective roles in liver cancer cells through partial activation of the PI3K (Montrer PIK3CA Anticorps)/AKT (Montrer AKT1 Anticorps) pathway, which may facilitate liver cancer progression and decrease the sensitivity to chemotherapy.
Irisin is upregulated in a murine model of fibrosis, but not in experimental NAFLD (Montrer TSC2 Anticorps) without significant fibrosis.
Irisin improved endothelial function by modulating HO-1 (Montrer HMOX1 Anticorps)/ adiponectin axis in perivascular adipose tissue (PVAT) in HFD-induced obese mice. These findings suggest that regulating PVAT function may be a potential mechanism by which irisin improves endothelial function in obesity.
results are the first to demonstrate that the protective effects of irisin in cardiomyoblasts exposed to hypoxia/reoxygenation might be associated with HDAC4 (Montrer HDAC5 Anticorps) degradation.
The results indicate that FNDC5 deficiency impairs autophagy and FAO and enhances lipogenesis via the AMPK (Montrer PRKAA1 Anticorps)/mTOR (Montrer FRAP1 Anticorps) pathway. FNDC5 deficiency aggravates whereas FNDC5 overexpression prevents the HFD-induced hyperlipemia, hepatic lipid accumulation, and impaired FAO and autophagy in the liver.
This research is the first to show that irisin modulates macrophage activity by reducing reactive oxygen species (ROS (Montrer ROS1 Anticorps)) overproduction, which could suggest its potential anti-inflammatory properties.
No FNDC5 expression was detected in normal or cancerous stomach tissues. FNDC5 expression in white and brown adipose tissues in the cancer group increased compared with the control and non-cancer groups.
Report showed that irisin suppressed cholesterol synthesis in hepatocytes through the activation of 5' AMP-activated protein kinase (AMPK (Montrer PRKAA2 Anticorps)) and subsequent inhibition of transcription and nuclear translocation of SREBP2 (Montrer SREBF2 Anticorps).
PGC1alpha regulates FNDC5 and its processed and secreted peptide Irisin, which has been proposed to play a critical role in energy expenditure and to promote neural differentiation of mouse embryonic stem cells. Review.
it is concluding that an enhanced expression of Fndc5 in neural progenitor cells is stimulated by Zfp521 (Montrer ZNF521 Anticorps) overexpression in these cells
these results indicate that unaltered endogenous irisin is required to maintain food intake in zebrafish.[irisin]
mouse homolog is linked to myoblast differentiation and development
fibronectin type III domain-containing protein 5
, fibronectin type III domain containing 5
, fibronectin type III repeat-containing protein 2
, peroxisomal protein