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Human Polyclonal CDK16 Primary Antibody pour IHC, IHC (p) - ABIN4344223
Yanagi, Krajewska, Matsuzawa, Reed: PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells. dans Cancer research 2014
Show all 3 Pubmed References
CDK16 is significantly up-regulated in non-small cell lung cancer tumor tissue and plays a role in promoting cell proliferation.
Authors provided the first evidence that CDK16 is an bona fide oncogene (Montrer RAB1A Anticorps) in HCC (Montrer FAM126A Anticorps), and multiple activating mechanisms at transcriptional and posttranscriptional levels together contributes to CDK16 up-regulation in HCC (Montrer FAM126A Anticorps).
PCTAIRE1 has a role in regulating p27 (Montrer PAK2 Anticorps), c-Myc (Montrer MYC Anticorps) levels and tumor growth in cutaneous cutaneous squamous cell carcinoma cells
CDK-16 upregulation in serous EOC cells may represent a negative feedback loop to promote ovarian cell differentiation in malignantly-transformed serous epithelial ovarian cancer cells
GALNT7 (Montrer GALNT7 Anticorps) and CDK16 were confirmed to be the direct targets of miR (Montrer MLXIP Anticorps)-494. These results suggested that miR (Montrer MLXIP Anticorps)-494 play an inhibitory role in the tumorigenesis of NPC (Montrer NPC1 Anticorps)
Activation of PCTAIRE-1 is mediated through interaction with the phosphorylated form of cyclin Y (Montrer CCNY Anticorps) in complex with 14-3-3 (Montrer YWHAQ Anticorps).
PCTK1 in the proliferation and survival of medulloblastoma characterized by cMYC (Montrer MYC Anticorps) amplification
PCTK1 regulates spindle orientation through phosphorylation of Ser83 on KAP0, a regulatory subunit of protein kinase A.
An unexpected role for PCTAIRE1 in regulating p27 (Montrer PAK2 Anticorps) stability, mitosis, and tumor growth.
Dysfunction of MKL2 and its transcriptional coactivation partner, serum response factor (SRF), was supported by a decrease in gene and protein expression of PCTAIRE1, a downstream target of MKL2:SRF heterodimer transcriptional activation
CCNYL1 regulates spermatogenesis through the interaction and modulation of CDK16.
Pctaire1 exerts promyogenic effects by regulating myoblast migration and process formation during skeletal myogenesis
a novel function of BRSK2 (Montrer BRSK2 Anticorps) in the regulation of GSIS in beta-cells via a PCTAIRE1-dependent mechanism and suggest that BRSK2 (Montrer BRSK2 Anticorps) is an attractive target for developing novel diabetic drugs.
Mice lacking CDK16 developed normally, but male mice were infertile. Spermatozoa isolated from their epididymis displayed thinning and elongation of the annulus region, adopted a bent shape, and showed impaired motility.
Cdk5 (Montrer CDK5 Anticorps)-dependent phosphorylation of Pctaire1 at Ser95 plays an important role in dendrite development
findings demonstrate that Pctaire1 interacts with p35 (Montrer CDK5R1 Anticorps), both in vitro and in vivo, and that phosphorylation of Pctaire1 by Cdk5 (Montrer CDK5 Anticorps) enhances its kinase activity
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells\; in exocytosis\; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.
PCTAIRE-motif protein kinase 1
, cell division protein kinase 16
, serine/threonine-protein kinase PCTAIRE-1
, PCTAIRE protein kinase 1
, PCTAIRE-1 protein kinase, alternatively spliced
, cyclin-dependent kinase 16