Aperçu des produits pour anti-Cyclin-Dependent Kinase 16 (CDK16) Anticorps

Human Cyclin-Dependent Kinase 16 (CDK16) interaction partners

1. CDK16 negatively modulates p53 signaling pathway to promote radioresistance in lung cancer cells.

2. CDK16 is significantly up-regulated in non-small cell lung cancer tumor tissue and plays a role in promoting cell proliferation.

3. PCTAIRE1 has a role in regulating p27, c-Myc levels and tumor growth in cutaneous cutaneous squamous cell carcinoma cells

4. CDK-16 upregulation in serous EOC cells may represent a negative feedback loop to promote ovarian cell differentiation in malignantly-transformed serous epithelial ovarian cancer cells

5. GALNT7 and CDK16 were confirmed to be the direct targets of miR-494. These results suggested that miR-494 play an inhibitory role in the tumorigenesis of NPC

6. Activation of PCTAIRE-1 is mediated through interaction with the phosphorylated form of cyclin Y in complex with 14-3-3.

7. PCTK1 in the proliferation and survival of medulloblastoma characterized by cMYC amplification

8. PCTK1 regulates spindle orientation through phosphorylation of Ser83 on KAP0, a regulatory subunit of protein kinase A.

9. An unexpected role for PCTAIRE1 in regulating p27 stability, mitosis, and tumor growth.

10. Dysfunction of MKL2 and its transcriptional coactivation partner, serum response factor (SRF), was supported by a decrease in gene and protein expression of PCTAIRE1, a downstream target of MKL2:SRF heterodimer transcriptional activation

11. Pctaire1 exerts promyogenic effects by regulating myoblast migration and process formation during skeletal myogenesis

12. a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs.

13. CCNY binding to CDK16 required a region upstream of the kinase domain and was found to be inhibited by phosphorylation of serine 153, a potential PKA phosphorylation site.

14. Cdk5-dependent phosphorylation of Pctaire1 at Ser95 plays an important role in dendrite development

15. Data show that various forms of PCTAIRE-1 transfected into neuroblastoma cell lines could either promote or inhibit neurite outgrowth, suggesting a potential role for the PCTAIRE-1 gene product in the control of neurite outgrowth.

16. Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein

Mouse (Murine) Cyclin-Dependent Kinase 16 (CDK16) interaction partners

1. CCNYL1 regulates spermatogenesis through the interaction and modulation of CDK16.

2. Pctaire1 exerts promyogenic effects by regulating myoblast migration and process formation during skeletal myogenesis

3. a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs.

4. Mice lacking CDK16 developed normally, but male mice were infertile. Spermatozoa isolated from their epididymis displayed thinning and elongation of the annulus region, adopted a bent shape, and showed impaired motility.

5. Cdk5-dependent phosphorylation of Pctaire1 at Ser95 plays an important role in dendrite development

6. findings demonstrate that Pctaire1 interacts with p35, both in vitro and in vivo, and that phosphorylation of Pctaire1 by Cdk5 enhances its kinase activity