AG-490 (Tyrphostin B42)

Détails pour le produit réf. ABIN3219853
Inhibition Assay (InhA), Functional Studies (Func)
Fonction AG-490 (Tyrphostin AG 490) is an inhibitor of EGFR with IC50 of 0.1 μM, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.
Attributs du produit Target: EGFR inhibitor, JAK inhibitor, HER2 inhibitor
Receptor: EGFR,JAK2,ErbB2
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Pureté 98.80 %
Formula C17H14N2O3
Solubility 100 mM in DMSO
Sujet JAK/STAT Signaling,Tyrosine Kinase/Adaptors
Poids moléculaire 294.30 g/mol
Numéro CAS 133550-30-8
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Stock -20 °C
Stockage commentaire For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Date de péremption 24 months