AT9283

Détails pour le produit réf. ABIN3220130
Application
Inhibition Assay (InhA), Functional Studies (Func)
Options
Fonction AT9283 is a potent JAK2/3 inhibitor with IC50 of 1.2 nM/1.1 nM in cell-free assays, also potent to Aurora A/B, Abl(T315I). Phase 2.
Attributs du produit Target: JAK inhibitor, Aurora Kinase inhibitor, Bcr-Abl inhibitor, GSK-3 inhibitor, FGFR inhibitor
Receptor: JAK3,JAK2,Aurora A,Aurora B,Abl1,GSK-3β, FGFR2,VEGFR3/FLT4
Status: Experimental
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Pureté 98.45 %
Formula C19H23N7O2
Solubility DMSO 76 mg/mL,Ethanol 38 mg/mL,Water <1 mg/mL
Sujet Angiogenesis,JAK/STAT Signaling
Poids moléculaire 381.43 g/mol
Numéro CAS 896466-04-9
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Stock -20 °C
Stockage commentaire For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Date de péremption 24 months