Bufalin

Détails pour le produit réf. ABIN3220284
Application
Inhibition Assay (InhA), Functional Studies (Func)
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Fonction Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu, it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in cancer cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway.
Attributs du produit Target: ATPase inhibitor
Receptor: Na+/K+-ATPase
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Pureté 98 %
Formula C24H34O4
Solubility 10 mM in DMSO
Sujet Membrane Transporter/Ion Channel
Poids moléculaire 386.52 g/mol
Numéro CAS 465-21-4
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Stock -20 °C
Stockage commentaire For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Date de péremption 24 months
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 image for Bufalin (ABIN3220284) Bufalin