Carfilzomib (PR-171)

Détails pour le produit réf. ABIN3220321
Application
Inhibition Assay (InhA), Functional Studies (Func)
Options
Fonction Carfilzomib is an epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S catalytic core subunit of the proteasome, a protease complex responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.
Attributs du produit Target: Protease inhibitor
Receptor: Proteasome
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Pureté 98 %
Formula C40H57N5O7
Solubility Soluble in DMSO
Sujet Proteases/Proteasome
Poids moléculaire 719.91 g/mol
Numéro CAS 868540-17-4
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Stock -20 °C
Stockage commentaire For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Date de péremption 24 months