Crizotinib (PF-02341066)

Détails pour le produit réf. ABIN3220459
Inhibition Assay (InhA), Functional Studies (Func)
Fonction Crizotinib an inhibitor of receptor tyrosine kinase for the treatment of non-small cell lung cancer (NSCLC). Verification of the presence of ALK fusion gene is done by Abbott Molecular's Vysis ALK Break Apart FISH Probe Kit. This verification is used to select for patients suitable for treatment. FDA approved in August 26, 2011.
Attributs du produit Tradename: XALKORI
Source of Compound: synthetic
Target: TGF-beta/Smad inhibitor,c-MET inhibitor
Receptor: ALK ,c-MET
Status: USP
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Pureté 99 % +
Formula C21H22Cl2FN5O
Solubility DMSO 9 mg/mL,Water <1 mg/mL
Sujet Tyrosine Kinase/Adaptors
Poids moléculaire 450.34 g/mol
Numéro CAS 877399-52-5
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Stock -20 °C
Stockage commentaire For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Date de péremption 24 months