CX5461

Détails pour le produit réf. ABIN3220466
Application
Inhibition Assay (InhA), Functional Studies (Func)
Options
Fonction CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
Attributs du produit Target: DNA/RNA Synthesis inhibitor
Receptor: A375,MIA PaCa-2
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Pureté 98 %
Formula C27H27N7O2S
Solubility 10 mM in DMSO
Sujet DNA Damage/DNA Repair
Poids moléculaire 513.61 g/mol
Numéro CAS 1138549-36-6
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Stock -20 °C
Stockage commentaire For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Date de péremption 24 months