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Caspase-Family Inhibitor Z-VAD-FMK Inhibitor

Func, CC, BR, InhA Cell-permeable 187389-52-2 Z-VAD-FMK, Z-VAD fluoromethylketone, Caspase-Family Inhibitor, pan-caspase inhibitor
Pubmed (13)
N° du produit ABIN412347
Plus shipping costs $45.00
100 μL ABIN412347
100 μL ABIN412347
local_shipping Destination: Etats-Unis
Envoi sous 2 à 3 jours ouvrables
  • Application
    Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
    A pan-caspase inhibitor
    Attributs du produit
    PubChem CID: 5737
    A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
    Single spot by TLC
    Chemical Name
    Z-VAD-FMK, Z-VAD fluoromethylketone, Caspase-Family Inhibitor, pan-caspase inhibitor
  • Indications d'application
    We recommend using 1000X dilutions for inhibiting caspase activity in Jurkat cell culture (e.g., Add 1 µL to 1 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
    For Research Use only
  • Format
    10 mM
    Conseil sur la manipulation
    Protect from light and moisture
    -20 °C
    Date de péremption
    6-12 months
  • Jouve, Despoix, Espeli, Gauthier, Cypowyj, Fallague, Schiff, Dignat-George, Vély, Leroyer: "The involvement of CD146 and its novel ligand Galectin-1 in apoptotic regulation of endothelial cells." dans: The Journal of biological chemistry, Vol. 288, Issue 4, pp. 2571-9, 2013 (PubMed).

    Liu, Deng, Lancto, Abrahamsen, Rutherford, Enomoto: "Biphasic modulation of apoptotic pathways in Cryptosporidium parvum-infected human intestinal epithelial cells." dans: Infection and immunity, Vol. 77, Issue 2, pp. 837-49, 2009 (PubMed).

    Dai, Liu, Tang, DeSano, Burstein, Davis, Pienta, Lawrence, Xu: "Molecularly targeted radiosensitization of human prostate cancer by modulating inhibitor of apoptosis." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 23, pp. 7701-10, 2008 (PubMed).

    Liu, Enomoto, Lancto, Abrahamsen, Rutherford: "Inhibition of apoptosis in Cryptosporidium parvum-infected intestinal epithelial cells is dependent on survivin." dans: Infection and immunity, Vol. 76, Issue 8, pp. 3784-92, 2008 (PubMed).

    Arai, Miyake, Voit, Nemoto, Wakeland, Grummt, Miyazaki: "Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 7, pp. 2289-94, 2007 (PubMed).

    Niikura, Dixit, Scott, Perkins, Kitagawa: "BUB1 mediation of caspase-independent mitotic death determines cell fate." dans: The Journal of cell biology, Vol. 178, Issue 2, pp. 283-96, 2007 (PubMed).

    Deng, Yin, Lu, Cai, Yin: "The apoptotic effect of brucine from the seed of Strychnos nux-vomica on human hepatoma cells is mediated via Bcl-2 and Ca2+ involved mitochondrial pathway." dans: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 91, Issue 1, pp. 59-69, 2006 (PubMed).

    Gillet, Dewals, Farnir, de Leval, Vanderplasschen: "Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo." dans: Cancer research, Vol. 65, Issue 20, pp. 9463-72, 2005 (PubMed).

    Pae, Choi, Oh, Lee, Ryu, Rhew, Kim, Chung: "Roles of heme oxygenase-1 in the antiproliferative and antiapoptotic effects of nitric oxide on Jurkat T cells." dans: Molecular pharmacology, Vol. 66, Issue 1, pp. 122-8, 2004 (PubMed).

    Song, Mahidhara, Zhou, Hoffman, Seol, Flavell, Billiar, Otterbein, Choi: "Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 2, pp. 1220-6, 2004 (PubMed).

    Fukazawa, Walter, Owen-Schaub: "Adenoviral Bid overexpression induces caspase-dependent cleavage of truncated Bid and p53-independent apoptosis in human non-small cell lung cancers." dans: The Journal of biological chemistry, Vol. 278, Issue 28, pp. 25428-34, 2003 (PubMed).

    Yen, Mar, Craciunescu, Edwards, Zeisel: "Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells." dans: The Journal of nutrition, Vol. 132, Issue 7, pp. 1840-7, 2002 (PubMed).

    Erdreich-Epstein, Tran, Bowman, Wang, Cabot, Durden, Vlckova, Reynolds, Stins, Groshen, Millard: "Ceramide signaling in fenretinide-induced endothelial cell apoptosis." dans: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 49531-7, 2002 (PubMed).

  • Poids moléculaire
    467.5 g/mol
    Numéro CAS
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