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Crizotinib (PF-02341066)

InhA, Func 877399-52-5

N° du produit ABIN4874682

Fiche de données

Application

Inhibition Assay (InhA), Functional Studies (Func)

Fonction

Crizotinib an inhibitor of receptor tyrosine kinase for the treatment of non-small cell lung cancer (NSCLC). Verification of the presence of ALK fusion gene is done by Abbott Molecular's Vysis ALK Break Apart FISH Probe Kit. This verification is used to select for patients suitable for treatment. FDA approved in August 26, 2011.

Attributs du produit

Tradename: XALKORI
Source of Compound: synthetic
Target: TGF-beta/Smad inhibitor,c-MET inhibitor
Receptor: ALK ,c-MET

Purification

All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.

Pureté

99 % +

Formula

C21H22Cl2FN5O

Solubility

DMSO 9 mg/mL,Water <1 mg/mL
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Nicotinamide
Inh 98-92-0 Pyridine-3-carboxylic acid amide

5-Azacytidine
Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Resveratrol
Act 501-36-0 3,4',5-Trihydroxy-trans-stilbene

Panobinostat
Inh 404950-80-7 (E)-N-Hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide

HPA (Hexyl-4-pentynoic acid)
Inh Cell-permeable 96017-59-3 2-(2-Propynyl)octanoic acid (racemic)

EX-527
Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)

Daminozide
Inh 1596-84-5 1-(2,2-Dimethylhydrazide)butanedioic acid

Indications d'application

Optimal working dilution should be determined by the investigator.

Restrictions

For Research Use only
Format

Solid

Stock

-20 °C

Stockage commentaire

For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.

Date de péremption

24 months
Sujet

Tyrosine Kinase/Adaptors

Poids moléculaire

450.34 g/mol

Numéro CAS

877399-52-5