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Balicatib

InhA, Func 354813-19-7

N° du produit ABIN4875365

Fiche de données

Application

Inhibition Assay (InhA), Functional Studies (Func)

Fonction

Balicatib is an inhibitor of cathepsin K with IC50 value of 1.4nM [1]. Balicatib is highly selective against cathepsin K over cathepsin B, L and S in the in vitro enzyme assay. However, the selectivity is not so high in cell-based enzyme assay. The lysosomotropic character of balicatib results in its accumulation in lysosomes and the subsequent nonselective off-target effects. The off-target effects also cause the skin adverse events of balicatib. As a cathepsin K inhibitor, balicatib is developed for osteoporosis. It has been reported to reduce the biochemical markers of bone resorption and increase bone mineral density in ovariectomized monkeys. In addition, balicatib shows benefits in new bone formation of postmenopausal women

Attributs du produit

Tradename: AAE581
Target: Cathepsin K inhibitor
Receptor: Cathepsin K

Purification

All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.

Pureté

98 %

Formula

C23H33N5O2

Solubility

Soluble in DMSO
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Nicotinamide
Inh 98-92-0 Pyridine-3-carboxylic acid amide

5-Azacytidine
Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Resveratrol
Act 501-36-0 3,4',5-Trihydroxy-trans-stilbene

Panobinostat
Inh 404950-80-7 (E)-N-Hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide

HPA (Hexyl-4-pentynoic acid)
Inh Cell-permeable 96017-59-3 2-(2-Propynyl)octanoic acid (racemic)

EX-527
Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)

Daminozide
Inh 1596-84-5 1-(2,2-Dimethylhydrazide)butanedioic acid

Indications d'application

Optimal working dilution should be determined by the investigator.

Restrictions

For Research Use only
Format

Solid

Stock

-20 °C

Stockage commentaire

For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.

Date de péremption

24 months
Sujet

Enzyme

Poids moléculaire

411.54 g/mol

Numéro CAS

354813-19-7