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CX5461

InhA, Func 1138549-36-6
N° du produit ABIN4876326
  • Application
    Inhibition Assay (InhA), Functional Studies (Func)
    Fonction
    CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
    Attributs du produit
    Target: DNA/RNA Synthesis inhibitor
    Receptor: A375,MIA PaCa-2
    Purification
    All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
    Pureté
    98 %
    Formula
    C27H27N7O2S
    Solubility
    10 mM in DMSO
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Solid
    Stock
    -20 °C
    Stockage commentaire
    For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
    Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
    Several freeze/thaw cycles should not damage the activity of our small molecule products.
    However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
    Date de péremption
    24 months
  • Sujet
    DNA Damage/DNA Repair
    Poids moléculaire
    513.61 g/mol
    Numéro CAS
    1138549-36-6
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