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AEE788

InhA, Func 497839-62-0
N° du produit ABIN4876387
  • Application
    Inhibition Assay (InhA), Functional Studies (Func)
    Fonction
    AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2.
    Attributs du produit
    Target: EGFR inhibitor, Bcr-Abl inhibitor, Src inhibitor, HER2 inhibitor
    Receptor: EGFR/c-Abl/FLT1/c-Src, HER2/ErbB2, HER4/ErbB4
    Purification
    All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
    Pureté
    98 %
    Formula
    C27H32N6
    Solubility
    100 mM in DMSO
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Solid
    Stock
    -20 °C
    Stockage commentaire
    For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
    Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
    Several freeze/thaw cycles should not damage the activity of our small molecule products.
    However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
    Date de péremption
    24 months
  • Sujet
    Tyrosine Kinase/Adaptors
    Poids moléculaire
    440.58 g/mol
    Numéro CAS
    497839-62-0
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