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Carfilzomib (PR-171)

InhA, Func 868540-17-4
N° du produit ABIN5678017
  • Application
    Inhibition Assay (InhA), Functional Studies (Func)
    Fonction
    Carfilzomib is an epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S catalytic core subunit of the proteasome, a protease complex responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.
    Attributs du produit
    Target: Protease inhibitor
    Receptor: Proteasome
    Purification
    All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
    Pureté
    98 %
    Formula
    C40H57N5O7
    Solubility
    Soluble in DMSO
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Solid
    Stock
    -20 °C
    Stockage commentaire
    For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
    Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
    Several freeze/thaw cycles should not damage the activity of our small molecule products.
    However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
    Date de péremption
    24 months
  • Sujet
    Proteases/Proteasome
    Poids moléculaire
    719.91 g/mol
    Numéro CAS
    868540-17-4
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