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Apitolisib (GDC-0980, RG7422)

InhA, Func 1032754-93-0
N° du produit ABIN5678194
  • Application
    Inhibition Assay (InhA), Functional Studies (Func)
    Fonction
    Apitolisib (GDC-0980, RG7422) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM in cell-free assays, respectively. Also a mTOR inhibitor with Ki of 17 nM in a cell-free assay, and highly selective versus other PIKK family kinases. Phase 2.
    Attributs du produit
    Target: PI3K inhibitor
    Receptor: p110α
    Purification
    All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
    Pureté
    98 %
    Formula
    C23H30N8O3S
    Solubility
    Soluble in DMSO
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Solid
    Stock
    -20 °C
    Stockage commentaire
    For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
    Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
    Several freeze/thaw cycles should not damage the activity of our small molecule products.
    However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
    Date de péremption
    24 months
  • Sujet
    PI3K/Akt/mTOR Signaling
    Poids moléculaire
    498.60 g/mol
    Numéro CAS
    1032754-93-0
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