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secretory PLA2s have important functions as genetic modifiers of inflammation and colon cancer.
PLA2G10 releases omega-3 polyunsaturated fatty acids, suppresses colitis, and promotes sperm fertility.
Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A2beta (iPLA2beta) and Group X Secreted Phospholipase A2 (sPLA2).
GX sPLA2 negatively regulated pancreatic insulin secretion by augmenting COX-2-dependent PGE2 production.
Mouse PLA2GX has a unique property of improving fertilization outcome among other secreted phospholipase A2 isoforms.
Data indicate that experimental allergic bronchitis (EAB) in was associated with increased expression of sPLA2, specifically sPLA2gX, in the lungs.
Authors propose that activation of GX-sPLA2 during H1N1pdm infection is an early step of pulmonary inflammation and its inhibition increases adaptive immunity and improves survival.
Pla2G10 limits the development of atherosclerosis in LDL receptor-null mice.
the use of a highly potent indole-based inhibitor of hGX-sPLA(2), RO061606 (which is ineffective against mGX-sPLA(2)), to assess the potential utility of GX-sPLA(2) blockade as a therapeutic intervention in asthma.
sPLA(2)-X in neutrophils plays a pathogenic role in abdominal aortic aneurysms in a mouse model.
sPLA2 plays a new role for fertilization by selecting a sperm subpopulation based on its effect on sperm motility.
Group X secretory phospholipase A2 promotes macrophage inflammatory responses by altering cellular cholesterol homeostasis and lipid raft content.
Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function.
the spatiotemporal expression of sPLA(2)-X in hair follicles, the presence of skin-specific machinery leading to sPLA(2)-X activation, a functional link of sPLA(2)-X with hair follicle homeostasis.
GX sPLA(2) promotes Ang II-induced pathological responses leading to abdominal aortic aneurysm formation
hydrolytic products generated by GX sPLA(2) negatively regulate adipogenesis, possibly by suppressing LXR activation
The overexpression of GX sPLA(2) significantly reduced ABCA1 and ABCG1 expression in J774 macrophage-like cells, whereas GX sPLA(2) deficiency in peritoneal macrophages was associated with enhanced expression.
Data show that GX sPLA(2) is expressed in mouse adrenal glands and functions to negatively regulate corticosteroid synthesis, most likely by negatively regulating StAR expression.
Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice
LDL modification by GXPLA2 [GXPLA2]
This report provides the first demonstration that Phosphatidylcholine-Isoprostanes are readily hydrolyzed by group IIA, V and X Secretory Phospholipases A2.
Data show that phospholipase A2 group IIA, V and X have different target/function related activity.
Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils
PLA2G10 variants are not significantly associated with plasma sPLA2 activity or with CHD risk.
Studies indicate that the expression of secreted phospholipases A2 (sPLA2s), most notably the group IIA, III and X enzymes, is dysregulated in various malignant tissues.
sPLA2GIII expression may be used as a risk factor for lymph node metastasis and a prognostic marker in colorectal cancer. In addition, sPLA2GIII and sPLA2GX may play opposing roles in colorectal carcinogenesis
hGX sPLA2 is a novel modulator of lipid metabolism that promotes breast cancer cell growth and survival by stimulating lipid droplet formation and fatty acid oxidation.
Data indicate that the expression of genes encoding hGIIA, hGIII and hGX sPLA2s (PLA2G2A, PLA2G3 and PLA2G10, respectively) in breast tumour biopsies differs from that in normal tissues.
The enzyme activity of sPLA2 is not altered in serum and cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis during the course of the disease.
Secreted phospholipase A2 group X plays a key role in regulating eicosanoid formation and the development of inflammation and airway hyperresponsiveness in murine models.
PLA2G10 expression in bone marrow cells controls a proatherogenic Th1 response and limits the development of atherosclerosis.
Molecular details of membrane fluidity changes during apoptosis and relationship to phospholipase A(2) activity
CONCLUSION: hGX-sPLA(2) secreted in inflamed tissues can contribute to local dendritic cell maturation, resulting in pro-Th1 cells, through the production of various lipid mediators from hydrolysis of either LDL and/or cell plasma membrane.
Group X secreted phospholipase A2 proenzyme is matured by a furin-like proprotein convertase and releases arachidonic acid inside of human HEK293 cells
sPLA(2) -IIA and sPLA(2) -X are the major sPLA(2) s in human airways, and suggest a link between the levels of sPLA(2) -X in the airways and several features of asthma.
Eosinophil cysteinyl leukotriene synthesis is mediated by exogenous secreted phospholipase A2 group X
Group X secreted phospholipase A2 induces production of VEGF-A and VEGF-C from lung macrophages by a receptor-mediated, catalytically independent mechanism and may play an important role in inflammatory and neoplastic angiogenesis and lymphangiogenesis.
mouse homolog has phospholipase A2 activity
, group 10 secretory phospholipase A2
, group X secretory phospholipase A2
, phosphatidylcholine 2-acylhydrolase 10
, group X phospholipase A2
, phosphatidylcholine 2-acylhydrolase GX
, phospholipase A2, group 10
, phospholipase A2 group X
, phospholipase A2, group X