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Human Polyclonal PLA2G4A Primary Antibody pour ELISA - ABIN562257
Zhang, Wu, Gan, Yu, Wang, Wang, Wang, Wang: Reduced group IVA phospholipase A2 expression is associated with unfavorable outcome for patients with gastric cancer. dans Medical oncology (Northwood, London, England) 2013
Human Polyclonal PLA2G4A Primary Antibody pour ELISA, WB - ABIN4345947
Gubern, Barceló-Torns, Barneda, López, Masgrau, Picatoste, Chalfant, Balsinde, Balboa, Claro: JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of group IVA phospholipase A2. dans The Journal of biological chemistry 2009
The expression of cPLA2alpha varies in multiple glioblastoma cell lines and is associated with chemoresistance rather than tumor development. cPLA2alpha depletion moderately inhibits glioblastoma growth and survival but remarkably sensitizes chemo-resistant glioblastoma cells to several chemotherapeutic agents.
Study provides evidence that BanI polymorphism of cPLA2 gene may be associated with somatic symptoms in patients with major depressive disorder in the Taiwanese population.
Results indicate that the BanI polymorphic variant contributes significantly to plasma glucose levels in female patients with schizophrenia. Females carrying the PLA2G4A-G allele (PLA2G4A-GG homozygous and PLA2G4A-AG heterozygous) presented with lower glucose levels than PLA2G4A-AA homozygous carriers, and the PLA2G4A genotype contributed approximately 6% of plasma glucose level variability in this group of patients.
High PLA2G4A expression is associated with obesity.
PLA2G4A up-regulated the protein expression of E-cadherin and down-regulated the protein expression of vimentin, which inhibited ESCC cell mobility and invasiveness.
A lipidomics-based LC/MS assay was used to define the specificity of cPLA2, iPLA2, and sPLA2 toward a variety of phospholipids. A unique hydrophobic binding site for the cleaved fatty acid dominates each enzyme's specificity rather than its catalytic residues and polar headgroup binding site.
The impaired phospholipid level and remarkable increased in cPLA2 concentration asserted their roles in the etiology of autism.
cPLA2alpha, which releases fatty acid from the sn-2 position of membrane-associated glycerophospholipids, is critically involved in coronavirus replication, most likely by producing lysophospholipids that are required to form the specialized membrane compartments in which viral RNA synthesis takes place
results suggested that IFN-gamma induces autophagy-associated apoptosis in CRC cells via inducing cPLA2-dependent mitochondrial ROS production.
These findings indicate the positive roles of cPLA2alpha in breast cancer cell growth, survival, migration and response to chemotherapy. Our work also highlights the therapeutic value of blocking cPLA2alpha to overcome chemoresistance in breast cancer.
These results indicate epigenetic regulation of cPLA2 and the potential of such regulation for treatment of chronic inflammation.
cPLA2alpha may play a key role in renal repair after injury through a PGE2-independent mechanism
This study indicates the potential role of cPLA2alpha in breast cancer metastasis and indicates that this molecule is a promising therapeutic target for breast cancer.
these studies suggests that cPLA2alpha expressed by neutrophils, but not epithelial cells, plays a significant role in infection-induced neutrophil transepithelial migration by mediating LTB4 synthesis during migration, which serves to amplify the magnitude of neutrophil recruitment in response to epithelial infection
cPLA2alpha activates PI3K/AKT and inhibits Smad2/3 during epithelial-mesenchymal transition of hepatocellular carcinoma cells.
Phospholipase activity is linked to energy metabolism, revealing cPLA2 as a central regulator of both lipidomics and energy flux.
present study indicates that among all cytosolic phospholipases A2, specific phospholipase A2 group IVA are the main enzymes involved in cigarette smoke induced anomalies in type I and type II lung epithelial cells
genetic association study in Quebec City population: Data suggest total plasma n-6 fatty acid phospholipid levels and C-reactive protein are modulated by SNPs in PLA2G4A and PLA2G6 alone or in combination with fish oil dietary supplementation.
cPLA2alpha plays an important role in cell cycle re-entry by quiescent prostate cancer cells
Letter: report instability of cytosolic phospholipase A2alpha variant resulting in severe impairment in platelet arachidonic acid metabolism.
result suggests that cPLAPgamma may act as a G protein, activating cPLA(2)alpha prior to reaching full intracellular Ca(2 ) concentrations
Ovulation is associated with an LH/hCG-dependent induction of PLA2G4A in GC via the adenylyl cyclase/cAMP pathway.
Activation of cytosolic phospholipase A2 and fatty acid transacylase is essential but not sufficient for thrombin-induced smooth muscle cell proliferation.
The results indicate that PLA2 activity in equine endometrium changes with the stage of the oestrous cycle and thus may be influenced by systemic hormone concentrations.
During pregnancy, PLA2 expression may be sufficient to initiate the cascade for prostaglandin f2alpha secretion and does not play a direct role in maternal recognition of pregnancy.
These results suggest a role of cPLA2 activation in facilitating oligomeric Abeta endocytosis by microglial cells through regulation of the membrane-cytoskeleton connectivity.
results indicate that cPLA2alpha and/or its downstream mediators, produced by bone marrow-derived cells, play a major role in eicosanoid production after renal injury and in renal fibrinogenesis
This study identifies a so-far undescribed mechanism of Shp1/Src modulation that promotes cell motility and that is dependent on the cPLA2 metabolite glycerophosphoinositol 4-phosphate.
The protein encoded by this gene is a member of the phospholipase A2 group IV family. This enzyme hydrolyzes membrane phospholipids, thereby releasing the polyunsaturated fatty acid, arachidonic acid.
cPLA2alpha is involved in TCDD-induced body weight loss, lipid accumulation in the liver, fetal hydronephrosis, and cytokine gene expression, and the molecular basis of TCDD toxicity differs considerably between target tissues and life stages.
This study demonstrated that the Potassium channels-mediated electrophysiologic responses are inhibited by cytosolic phospholipase A2alpha ablation.
Compared to cPLA2alpha(+/+) Tg-AD mice, the amyloid plaque formation was significantly downregulated in the brain of cPLA2alpha(+/-) Tg-AD mice, but not in cPLA2alpha(-/-) Tg-AD mice.
the cytosolic phospholipase cPLA2alpha is activated through Gbetagamma downstream of Smo to release arachidonic acid. Arachidonic acid binds Smo and synergizes with CRD-binding agonists, promoting Smo ciliary trafficking and high-level signaling.
In microglia, cPLA2 up-regulates the expression of CD40 protein.
LacCer alone simultaneously stimulates two processes to activate cPLA2 alpha: a phosphorylation signal and attachment of the enzyme to substrate membranes.
this study shows that cPLA2alpha contributes to immune surveillance and host defense in the lung to prevent infection by the commensal fungus Candida albicans and to dampen inflammation
Reduction of cPLA2alpha in the brainstem and spinal cord significantly attenuated the development of an animal model of amyotrophic lateral sclerosis.
Data suggest that the ability of pyrrophenone to block endoplasmic reticulum (ER) calcium release is an off-target effect since it occurs in fibroblasts lacking cytosolic phospholipase A2alpha (cPLA2alpha).
these results show that preadipocyte cPLA2alpha activation is a hitherto unrecognized factor for adipogenesis in vitro and in vivo.
The data emphasize the importance of the PLCeta2 EF-hand domain and articulation of PLCeta2 with LIMK-1 in regulating neuritogenesis.
show that accumulation of Abeta induced elevation of APP protein expression mediated by cPLA2 alpha, PGE2 release, and CREB activation via protein kinase A pathway
Prostaglandins from cPLA2-alpha/COX1 pathway and mitogen-activated protein kinases regulate gene expression in Candida albicans-infected macrophages.
critical role in development of mouse model of colitis
The goal for this study is to elucidate the role of cPLA2IV in mediating the oxidative and inflammatory responses in microglial cells
Data show that glycation end products (AGE) increase PIP2 production, arachidonic acid release and reactive oxygen species via cytosolic phospholipase A2 activation, and inhibit Na+ K+ ATPase surface expression via PIP5Kgamma.
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
, calcium-dependent phospholipid-binding protein
, cytosolic phospholipase A2
, phosphatidylcholine 2-acylhydrolase
, phospholipase A2 group IVA
, phospholipase A2 cytosolic
, Phospholipase A2 group IVA
, phospholipase A2, group IB (pancreas)
, Cytosolic phospholipase A2 (CPLA2)
, Type IV PLA2
, cytosolic PLA2
, phospholipase A2, group 4
, phospholipase A2, group IVA (cytosolic, calcium-dependent)