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anti-Mouse (Murine) PLA2G5 Anticorps:
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Cow (Bovine) Polyclonal PLA2G5 Primary Antibody pour WB - ABIN2776806
Wootton, Arora, Drenos, Thompson, Cooper, Stephens, Hurel, Hurt-Camejo, Wiklund, Humphries, Talmud: Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study. dans Human molecular genetics 2007
Show all 2 Pubmed References
Deficiency of GV sPLA2 (Montrer PLA2G2A Anticorps) results in diminished glucose-stimulated insulin (Montrer INS Anticorps) secretion in isolated pancreatic beta-cells
GV sPLA2 (Montrer PLA2G2A Anticorps) is involved in the maintenance of tubular cell function and integrity, promoting sodium retention through increased cortical (Na+ + K+)-ATPase (Montrer ATP1A1 Anticorps) expression and activity.
AdPLA2 plays an important role in promoting tumorigenesis and disease progression by modulating the production of prostaglandins and may serve as a potential therapeutic target in TSC (Montrer SLC12A3 Anticorps) and LAM (Montrer LSAMP Anticorps).
PLA2G5 hydrolyzed phosphatidylcholine (Montrer SGMS2 Anticorps) in fat-overladen low-density lipoprotein to release unsaturated fatty acids, which prevented palmitate-induced M1 macrophage polarization.
Key Data shows the role of group v secreted phospholipase A2 (Montrer YWHAZ Anticorps) in Th2 cytokine and dendritic cell-driven airway hyperresponsiveness and remodeling.
Our studies identified a unique function of gV-sPLA2 (Montrer PLA2G2A Anticorps) in activation of macrophages
The impact of group V sPLA(2 (Montrer PLA2G2A Anticorps)) deficiency on angiotensin (Ang) II (Montrer AGT Anticorps)-induced cardiac fibrosis in apoE (Montrer APOE Anticorps) deficient mice was investigated.
The results indicate that the PLA(2) activity also plays a substantial role in protecting cells against oxidant stress caused by an exogenous hydroperoxide.
GV sPLA(2 (Montrer PLA2G2A Anticorps)) in bone marrow-derived myeloid cells as well as non-myeloid cells, which are likely bronchial epithelial cells, participate in the regulation of the innate immune response to pulmonary infection with E. coli.
Data from cuprizone-induced model of multiple sclerosis suggest that sPLA2 down-regulation during remyelination can limit release of AA and consequent production of pro-inflammatory PGs/TXB2 (which are increased during demyelination).
This report provides the first demonstration that Phosphatidylcholine-Isoprostanes are readily hydrolyzed by group IIA, V and X Secretory Phospholipases A2.
Low GV-PLA2 expression is associated with cancer.
Data show that phospholipase A2 group IIA, V and X have different target/function related activity.
The clinical findings in this family suggest a diagnosis of benign familial fleck retina with excellent prognosis, in which the PLA2G5 gene may play a role.
sPLA2 (Montrer PLA2G2A Anticorps)-V plays a thrombogenic role by impairing the ability of EPCR (Montrer PROCR Anticorps) to promote protein C activation.
results demonstrate that EPCR (Montrer PROCR Anticorps) is overexpressed and mediates the aggressive behavior of rheumatoid synovial fibroblasts, and is likely driven by group V secretory phospholipase A2 (Montrer YWHAZ Anticorps)
expression of PLA2s (Montrer PLA2G2A Anticorps)-IIE and -V correlates with the development of calcification as well as the expression of pro-osteogenic molecules in human aortic valves
Summarizing, Der (Montrer GDF3 Anticorps) p1 and Fel (Montrer CREB3L2 Anticorps) d1 involve phospholipase A2 (Montrer YWHAZ Anticorps) enzymes in their action.
There is no association between rs525380 polymorphism of PLA2G5 and coronary heart disease.
Our results demonstrate the association of the PLA2G5 rs11573191 polymorphism with premature CAD (Montrer CAD Anticorps). In our study, it was possible to distinguish one haplotype associated with increased risk of premature CAD (Montrer CAD Anticorps) and hypertension.
This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined.
calcium-dependent phospholipase A2
, phospholipase A2, group V
, group V phospholipase A2
, phosphatidylcholine 2-acylhydrolase 5
, Ca2+-dependent phospholipase A2
, phospholipase A2, group 5