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Human Polyclonal PLEK Primary Antibody pour ELISA, WB - ABIN250083
Hunter, Mackintosh, Hers: Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP levels in human platelets. dans The Journal of biological chemistry 2009
Show all 2 Pubmed References
Only one gene, pleckstrin , was significantly overexpressed in periodontitis,cardiovascular disease, rheumatoid arthritis and ulcerative colitis , implicating this gene as an important networking link between these chronic inflammatory diseases
These findings reveal a novel role of the PLD1-pleckstrin homology domain as a positive regulator of endocytosis and provide a link between PLD1 and HIF-1alpha (Montrer HIF1A Anticorps) in the EGFR (Montrer EGFR Anticorps) endocytosis pathway.
crystallization and preliminary X-ray diffraction analysis of the first 2 domains of pleckstrin (NPHDEP); work demonstrates that NPHDEP behaves as a monomer in solution and suggests that all 3 pleckstrin domains contribute to the dimerization interface
Here they show that the PH domain from Bcr-Abl (Montrer ABL1 Anticorps) binds a number of proteins involved in vital cellular processes in leukemogenesis.
A pleckstrin homology domain located in G protein-coupled receptor kinase-2 (GRK2 (Montrer ADRBK1 Anticorps)) residue 548 to 660 plays a significant role in mediating interaction between protein kinase C beta 1 (Montrer PRKCB Anticorps) and GRK2 (Montrer ADRBK1 Anticorps).
The human pleckstrin-1 solution nuclear magnetic resonance structure of the C-terminal pleckstrin homology domain was reported.
Proteins beta3 integrin (Montrer ITGB3 Anticorps), Vav3 (Montrer VAV3 Anticorps), Plekhm1 (Montrer PLEKHM1 Anticorps), and Src (Montrer SRC Anticorps), implicated in attachment defects, had normal exon sequences in a new type of osteopetrosis (Montrer CSF1 Anticorps).
Idirect associations between plek and actin through 17 beta-hydroxysteroid dehydrogenase 4 (Montrer HSD17B4 Anticorps), alpha-actinin (Montrer ACTN1 Anticorps), moesin (Montrer MSN Anticorps), radixin (Montrer RDX Anticorps) and factor XIIIA (Montrer F13A1 Anticorps), is proposed.
Targeting of the pleckstrin homology domain of AKT (Montrer AKT1 Anticorps) was studied in cancer treatment in mouse models.
pleckstrin regulates the fusion of granules to the cell membrane and is an essential component of PKC-mediated exocytosis in platelets
Major protein kinase C substrate of platelets.
, platelet 47 kDa protein