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anti-Mouse (Murine) TPTE2 Anticorps:
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these results suggest that TSLP (Montrer TSLP Anticorps)-TSLPR (Montrer CRLF2 Anticorps) signaling is pivotal in the induction of nasal respiratory immunity against pathogenic pneumococcal infection
A novel mouse xenograft model to study the role of TSLP (Montrer TSLP Anticorps)-induced CRLF2 (Montrer CRLF3 Anticorps) signals in normal and malignant human B lymphopoiesis has been developed.
High-cholesterol diet increased TSLPR (Montrer CRLF2 Anticorps) expression and atherosclerosis. High-dose ticagrelor moderated this trend. It modulated platelet activity and atherosclerosis mediated by TSLPR (Montrer CRLF2 Anticorps), potentially through the PI3K/Akt (Montrer AKT1 Anticorps) signal pathway.
Activating thymic stromal lymphopoietin (Montrer TSLP Anticorps) promotes atherosclerosis by inducing Th17/Treg imbalance through TSLPR (Montrer CRLF2 Anticorps) signaling in a mouse model.
Suggest that Treg defects in ApoE (Montrer APOE Anticorps)(-/-) mice might partially be attributed to the disruption of TSLP (Montrer TSLP Anticorps)-TSLPR (Montrer CRLF2 Anticorps)-LAP signaling in epithelial cells and dendritic cells.
The structure of the mouse TSLP (Montrer TSLP Anticorps)-mediated signaling complex reveals how TSLP (Montrer TSLP Anticorps) establishes extensive interfaces with its cognate receptor (TSLPR (Montrer CRLF2 Anticorps)).
TSLPR (Montrer CRLF2 Anticorps) helps to create a permissive microenvironment for the development and pulmonary metastasis of mammary carcinoma in a mouse model using implanted 4T1 tumour cells.
A previously unrecognized role was found for TSLP (Montrer TSLP Anticorps)/TSLPR (Montrer CRLF2 Anticorps) signaling in type 2 immunity as an important enhancer for the development of alternately activated macrophages as well as for chemokine (Montrer CCL1 Anticorps) production.
mice deficient in TSLP receptors on LCs abrogated the induction of OVA-specific IgE levels upon epicutaneous OVA sensitization.
Increased susceptibility to autoimmune gastritis in thymic stromal lymphopoietin receptor (Montrer CRLF2 Anticorps)-deficient mice.
The role of TPTE2 in gallbladder cancer cells
TPTE2 was originally reported to be a phosphoinositide 3'-phosphatase, like the tumor suppressor PTEN. Later on, other homologous phosphatases, such as Ci-VSP (Montrer TPTE Anticorps) and Dr-VSP (Montrer TPTE Anticorps), have been described. These proteins are 5'-phosphatases. More recently, using a chimeric construct, we have shown that the catalytic domain of TPTE2 behaves as a 5'-phosphatase as well.
findings suggest that C2-domain of TPIP-C2 may act as a dominant negative effector, which may bind to and arrest the cell proliferation signalling complex
the TPIP splice-variant (TPIP-C2) mRNA is expressed in human and mouse tissues and strongly inhibits cell growth in HeLa cells
TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.
, TSLP receptor
, cytokine receptor-like molecule 2
, delta 1
, lymphocyte antigen 114
, thymic stromal lymphopoietin protein receptor
, thymic stromal-derived lymphopoietin, receptor
, transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
, type I cytokine receptor delta 1
, PTEN-like inositol lipid phosphatase
, TPIP lipid phosphatase
, TPTE and PTEN homologous inositol lipid phosphatase
, lipid phosphatase TPIP
, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2
, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2