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anti-Human VAC14 Anticorps:
anti-Mouse (Murine) VAC14 Anticorps:
anti-Rat (Rattus) VAC14 Anticorps:
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The association data demonstrated strong correlations between rs8060947 and VAC14 expression and between rs8060947 and S. Typhi invasion. The direction of effects for the different alleles led to the hypothesis that reducing VAC14 expression would increase S. Typhi invasion.
A genome-wide association study of a prospectively enrolled patient cohort identified an single nucleotide polymorphism in VAC14 that predicts sensitivity to docetaxel-induced peripheral neuropathy.
Biallelic rare coding variants in VAC14 was identified in a female neonate with Yunis-Varon syndrome. Cultured patient fibroblasts exhibited a YVS-like vacuolation ameliorated by ML-SA1 (Montrer STAG1 Anticorps).
The similar age of onset and neurological decline in the two unrelated children define a recessive disorder resulting from compound heterozygosity for deleterious variants of VAC14.
Rab7 GAP TBC1D15 (Montrer TBC1D15 Anticorps) with Vac14.
a novel regulatory mechanism whereby ArPIKfyve enhances Sac3 (Montrer MCM3AP Anticorps) abundance by attenuating Sac3 (Montrer MCM3AP Anticorps) proteasome-dependent degradation and suggest that a failure of this mechanism could be the primary molecular defect in the pathogenesis of CMT4J.
the PIKfyve (Montrer PIKFYVE Anticorps)-associated hVac14 protein has a major role in activating PIKfyve (Montrer PIKFYVE Anticorps) and thereby regulating PtdIns(3,5)P(2) synthesis and endomembrane homeostasis in mammalian cells
describe a novel interaction between the PDZ domain (Montrer INADL Anticorps) of nitric oxide synthase (Montrer NOS Anticorps) and Vac14
demonstrate a coupling between the machinery for PtdIns(3,5)P2 synthesis and turnover achieved through a physical assembly of PIKfyve (Montrer PIKFYVE Anticorps), ArPIKfyve, and Sac3 (Montrer MCM3AP Anticorps).
The authors data indicate that the PAS (Montrer PASK Anticorps) complex is organized to provide optimal PIKfyve (Montrer PIKFYVE Anticorps) functionality and is maintained via ArPIKfyve homomeric and heteromeric interactions.
Thus, VAC14, PI(3,5)P(2) and/or PI(5)P play a role in controlling postsynaptic function via regulation of endocytic cycling of AMPA (Montrer GRIA3 Anticorps) receptors.
a novel regulatory mechanism whereby ArPIKfyve enhances Sac3 (Montrer FIG4 Anticorps) abundance by attenuating Sac3 (Montrer FIG4 Anticorps) proteasome-dependent degradation and suggest that a failure of this mechanism could be the primary molecular defect in the pathogenesis of CMT4J.
The data demonstrate for the first time a physical association between functionally related PIKfyve (Montrer PIKFYVE Anticorps) and ArPIKfyve in 3T3-L1 adipocytes.
report the characterization of a mouse mutant lacking Vac14, a regulator of PI(3,5)P(2) synthesis
The authors show that Vac14 exerts an effect as a scaffold for the PI(3,5)P2 regulatory complex by direct contact with the known regulators of PI(3,5)P2: Fig4 (Montrer FIG4 Anticorps), Fab1, Vac7 and Atg18 (Montrer WIPI1 Anticorps).
The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390). VAC14 functions as an activator of PIKFYVE (Sbrissa et al., 2007
protein VAC14 homolog
, Tax1 (human T-cell leukemia virus type I) binding protein 1
, Tax1 (human T-cell leukemia virus type I) binding protein 2
, tax1-binding protein 2
, vacuole morphology 14
, vacuole 14 protein