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anti-Mouse (Murine) Integrin beta 4 Anticorps:
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Mouse (Murine) Monoclonal Integrin beta 4 Primary Antibody pour IHC (f), IHC (fro) - ABIN967380
Giancotti: Signal transduction by the alpha 6 beta 4 integrin: charting the path between laminin binding and nuclear events. dans Journal of cell science 1997
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Human Monoclonal Integrin beta 4 Primary Antibody pour CyTOF, FACS - ABIN4900094
Mierke, Frey, Fellner, Herrmann, Fabry: Integrin α5β1 facilitates cancer cell invasion through enhanced contractile forces. dans Journal of cell science 2011
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Human Monoclonal Integrin beta 4 Primary Antibody pour FM, ICS - ABIN2688877
Hemler, Crouse, Sonnenberg: Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines. dans The Journal of biological chemistry 1989
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Human Monoclonal Integrin beta 4 Primary Antibody pour FACS - ABIN2688875
Jones, Kurpakus, Cooper, Quaranta: A function for the integrin alpha 6 beta 4 in the hemidesmosome. dans Cell regulation 1991
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Human Monoclonal Integrin beta 4 Primary Antibody pour IHC (fro), FACS - ABIN2688876
Kennel, Epler, Lankford, Foote, Dickas, Canamucio, Cavalierie, Cosimelli, Venturo, Falcioni: Second generation monoclonal antibodies to the human integrin alpha 6 beta 4. dans Hybridoma 1990
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Human Polyclonal Integrin beta 4 Primary Antibody pour ELISA, WB - ABIN548462
Shaw: Identification of insulin receptor substrate 1 (IRS-1) and IRS-2 as signaling intermediates in the alpha6beta4 integrin-dependent activation of phosphoinositide 3-OH kinase and promotion of invasion. dans Molecular and cellular biology 2001
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Human Polyclonal Integrin beta 4 Primary Antibody pour ELISA, WB - ABIN548463
Dans, Gagnoux-Palacios, Blaikie, Klein, Mariotti, Giancotti: Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes. dans The Journal of biological chemistry 2001
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Ferret Monoclonal Integrin beta 4 Primary Antibody pour FACS, IF - ABIN2478032
Gleeson: HIV testing panel: the difficult issues. dans Medical Section proceedings : the ... annual Meeting of the Medical Section of the American Council of Life Insurance. American Council of Life Insurance. Medical Section. Meeting 1991
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Ferret Monoclonal Integrin beta 4 Primary Antibody pour IHC (fro), FACS - ABIN2478034
Martel, Aasted: Characterization of antibodies against ferret immunoglobulins, cytokines and CD markers. dans Veterinary immunology and immunopathology 2009
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Expression of the beta 4 subunit of the alpha 6 beta 4 integrin induces monocytic differentiation of 32D/v-Abl transformed cells. alpha 6 beta 4 integrin promotes growth arrest and differentiation by modulating Abl kinases and p73 protein pathway(s).
These data indicate that integrin alpha6beta4 and PMP22 cooperate to organize the internode and to allow proper propagation of the axonal signal along the axons.
ITGB4 deficiency leads to severe allergy-induced airway inflammation and airway hyper-responsiveness.
The results of this study suggested that ITGB4 knockout induced chronic inflammation mediated the comorbidity of asthma and bipolar disorder.
he potential effect of Ntn-1 on angiogenesis is further verified by the mouse hindlimb ischemia model, where the pre-activation of hUCB-MSCs with Ntn-1 significantly improved vascular regeneration. These results demonstrate that Ntn-1 plays an important role in the tissue regeneration process of hUCB-MSC via the lipid raft-mediated Inalpha6beta4 signaling pathway.
MARVELD1 mediated the invasion of trophoblast cells via regulation of the expression of integrin beta4 during placenta development.
Integrin beta4 contributes to mammary gland development by sustaining PTHrP expression and enabling PTHrP signaling.
keratins have a role in controlling beta4-integrin endocytosis involving a plectin-Erk1/2-dependent mechanism relevant for epidermal differentiation and pathogenesis
Up-regulation of integrin beta4 and TRPV1 in migrating keratinocytes.
Ectopic induction of Nur77 in endothelial cells is sufficient to improve skin wound healing. Furthermore, TR3/Nur77 regulates the expression of integrin beta4 by targeting its promoter activity.
Col17a1/ keratinocytes exhibited increased spreading on laminin 332 and accelerated, but less directed cell motility. These effects were accompanied by increased expression of the integrin subunits beta4 and beta1.
Both annexin A7 and integrin beta4 were essential for small molecule, 6-amino-2, 3-dihydro-3-hydroxymethyl-1, 4-benzoxazine-induced autophagy.
Findings indicate a function for Id2 in regulating Snai1-mediated repression of integrin beta4.
Lack of endothelial beta4 integrin had no effect on vascular development, integrity, or endothelial proliferation
Targeted deletion of the signaling domain of beta4 inhibited prostate tumor growth and progression in response to loss of p53 and Rb function in a model of prostate cancer (PB-TAg mice).
Deficiency of integrin alpha(6)beta(4) is modestly but significantly suppressed reporter-gene transduction by papillomaviruses in conditional integrin beta(4) knockout mice.
aberrant expression of alpha6beta4 integrin in post-mitotic epidermal keratinocytes stimulates a pro-tumorigenic skin microenvironment
The expression of beta4 integrin in interstitial, vessel-associated cells with myogenic activity within adult skeletal muscle.
Data show that beta4 integrin associates with MMP9 and that its ectodomain is a target for cleavage by MMP9 in vivo under pathological conditions.
Integrin beta4 signaling promotes mammary tumor cell adhesion to brain microvascular endothelium by inducing ErbB2-mediated secretion of VEGF
beta1 and beta4 integrins prefer the extended conformation over bent conformation under the Ca2+-induced low-affinity condition.
When beta4 integrin is knocked down there is a loss of vimentin filaments from lamellipodia.
soluble nectin-4 ecto-domain promotes breast cancer induced angiogenesis via endothelial Integrin-beta4
our data indicate the existence of a positive feedback loop between KLF4 and ITGB4 that promotes GSC self-renewal and gliomagenesis, suggesting that ITGB4 may be a valuable therapeutic target for glioma.
Study reports co-segregation of three rare, protein-changing variants in the ITGB4 gene with schizophrenia (SCZ) in 2 families; provides further evidence from case control cohorts that variants in these families may contribute to susceptibility to SCZ and/or bipolar disorder in the wider population; also demonstrates that when these variants are present on the same haplotype there is an increase in cell proliferation.
RUNX1 regulates ITGA6 through a consensus RUNX1 binding motif in its promoter
High ITGB4 expression is associated with drug resistance in colorectal cancer.
ITGB4 plays a tumorigenic and pro-metastatic role mediated by Slug
N-glycosylation controlled the EGFR complex formation with integrin alpha5beta1 or alpha6beta4
correlation analysis indicated that the expression of ARRDC3 was negatively correlated with ITGbeta4 in clinical prostate cancer (PCa) tissues and cell lines. Our data revealed that ARRDC3 can serve as a tumor suppressor to inhibit PCa progression and an independent marker to predict the risk of biochemical recurrence and metastasis after radical resection of PCa.
ITGB4(+) cancer stem cell (CSC)-enriched mesenchymal cells reside in an intermediate epithelial/mesenchymal phenotypic state.
These findings suggest that the integrin beta4-FAK/Src signaling axis may play a crucial role in clonorchiasis-associated cholangiocarcinoma metastasis during tumor progression.
IGF2 also requires integrin binding for signaling functions, and the IGF2 mutants that cannot bind to integrins act as antagonists of IGF1R.
MUC5AC interacts with integrin beta4 that mediates phosphorylation of FAK at Y397 leading to lung cancer cell migration.
Increased integrin alpha6beta4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancers.
a significant reduction in the protein distribution of collagen IV (P<0.0001), collagen VII (P<0.001), collagen XVII (P<0.01), integrin beta4 (P<0.001) and laminin-332 (P<0.0001) in intrinsically aged skin.
alpha6beta4 integrin is a positive regulator of collective cell migration of A549 cells through influence on signal pathways in leader cells.
For the in vivo experiment, miR-182-5p overexpression also promoted the growth and progression of prostate cancer tumors. In this regard, we suggest that miR-182-5p may be a key androgen receptor-regulated factor that contributes to the development and metastasis of Chinese prostate cancers and may be a potential target for the early diagnosis and therapeutic studies of prostate cancer.
data indicate that the beta4 integrin/FAK complex and subsequent FAK activation are essential regulators during the tumorigenicity of colon cancer
This work investigates alpha6beta4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an Argentinian population. No subjects carrying the R1281W mutation in the ITGB4 gene were found and this absence could reflect its high deleterious impact on proteins, so it would be eliminated from the population by natural selection.
integrin alpha6beta4 was indeed involved in dairy cow mammary development.
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
integrin beta 4
, integrin beta-4
, CD104 antigen
, integrin beta-4 subunit