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anti-Mouse (Murine) Integrin beta 7 Anticorps:
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Human Monoclonal Integrin beta 7 Primary Antibody pour FACS - ABIN2689794
Butcher, Picker: Lymphocyte homing and homeostasis. dans Science (New York, N.Y.) 1996
Show all 4 Pubmed References
Mouse (Murine) Monoclonal Integrin beta 7 Primary Antibody pour CyTOF, FACS - ABIN4899531
Richard, Roy, Audoy-Rémus, Tremblay, Vallières: Crawling phagocytes recruited in the brain vasculature after pertussis toxin exposure through IL6, ICAM1 and ITGαM. dans Brain pathology (Zurich, Switzerland) 2011
Human Monoclonal Integrin beta 7 Primary Antibody pour FACS - ABIN4896277
Sereti, Estes, Thompson, Morcock, Fischl, Croughs, Beq, Lafaye de Micheaux, Yao, Ober, Wilson, Natarajan, Imamichi, Boulassel, Lederman, Routy: Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration. dans PLoS pathogens 2014
Transmission of integrin beta7 transmembrane domain topology enables gut lymphoid tissue development.
lack of beta7 integrin significantly impairs tumor growth without affecting tumor frequencies, with a mild translatable effect on overall survival.
Loss of MAdCAM-1 has beneficial effects regarding the development of NASH - manifested by reduced hepatic oxidative stress and decreased inflammation. In contrast, beta7-Integrin-deficiency results in increased steatohepatitis.
AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.
Glycosylation of V1V2 domain of HIV envelope protein determined its binding to alpha4ss7 integrin.
beta7 integrin, when expressed by hematopoietic stem cells (HSC), interacted with its endothelial ligand MAdCAM-1 in the Bone marrow microenvironment, thereby promoting HSC homing and engraftment.
CCR9 and Integrin-beta7 expression has a differential effect on graft fate during acute graft-versus-host disease (GVHD) of the liver depending on the GVHD target tissue.
Data indicate a role of integrin alpha4beta7 (alpha4beta7) in diet-induced atherosclerosis.
The E-cadherin beta-7 integrin pathway probably controls migration of enterocytes within the small intestinal surface lining epithelial layer.
alpha4beta7 serves as an attachment factor for some HIV-1 strains.
KLF3 acts as transcriptional repressor for the leukocyte-specific integrin beta7 (Itgb7, Ly69) by binding to the beta7 promoter, as revealed by chromatin immunoprecipitation.
Mice lacking beta7 integrins in the innate immune compartment are more susceptible to intestinal inflammation, which is correlated with a requirement of beta7 integrins to reconstitute gut mononuclear phagocytes with tolerogenic potential.
beta7 integrin expression on cells of the innate immune system contributes to the critical role of beta7 integrin in the process of B cell tolerance.
E-cadherin and alpha(E)beta(7) integrin on dendritic epidermal T cells regulate their activation threshold through binding to E-cadherin on keratinocytes
lack of alpha4beta7 or E-selectin significantly reduced trafficking of CD4 T cells to the GT of mice infected with C. muridarum.
gene knock-outs display defective contact hypersensitivity responses due to impaired t cell migration to skin
role in migration of B cells into pancreatic lymph nodes in NOD mice
Strong positive reactions for integrin beta7 are seen on the uterine natural killer cell surface from gestational days 8 to 10, mainly on those cells found near the blood vessels, becoming completely negative after the twelfth gestational day.
beta(7) integrins play an essential role in spontaneous chronic ileitis in vivo by promoting homing of disease-exacerbating B cells to mesenteric lymph nodes and other intestinal tissues
Using an ex vivo flow cytometry assay, the authors found that simian immunodeficiency virus mac239-infected cells expressed significantly lower levels of integrin alpha4beta7 than did uninfected cells.
gut-homing alpha4beta7 CD4(+) T cells and their functional subsets were profoundly depleted during acute HIV-1 infection.
Collectively, these data suggest a role for alpha4beta7 integrin in HIV infection that is influenced by both viral and host factors including the sequence of the HIV gp120 alpha4beta7 binding motif, the cytokine milieu and bacterial vaginosis in the genital tract.
HIV-1 virions and many gp120s lack detectable alpha4beta7 binding activity.
circulating trisomy 12 CLL cells also have increased expression of the integrins CD11b, CD18, CD29, and ITGB7, and the adhesion molecule CD323.
Disruption of the hydrophobic contacts induces the active conformation of integrin alpha 4 beta 7.
Two conserved disulfide bonds located at integrin alpha4C589-C594 and beta7C494-C526 activated alpha4beta7.
Only rotavirus specific CD4 T cells expressed intestinal homing receptors alpha4beta7 and CCR9.
Data indicate that signaling by HIV-1 gp120 through integrin alpha4beta7 resulted in increased expression of the immunosuppressive cytokine TGF-beta1 and FcRL4.
analysis of the molecular basis for alpha4beta7-mediated rolling cell adhesion and a novel regulatory element of integrin affinity and signaling
Integrin alpha4beta7 binds gp120 but does not mediate HIV envelope-induced death signaling.
Data suggest that monoclonal antibody J19 is a potentially powerful tool for both studies on alpha(4)beta(7) activation mechanism and development of novel therapeutics targeting the activated lymphocyte expressing high affinity alpha(4)beta(7).
Consistent with structural predictions, strain increases beta-integrin binding to FLNA, whereas it causes FilGAP to dissociate from FLNA, providing a direct and specific molecular basis for cellular mechanotransduction
a role for integrin-beta7 in MM-cell adhesion, migration, and BM homing, and pave the way for a novel therapeutic approach targeting this molecule.
Data show that integrin beta7 and CCR6 identify four distinct stages of memory CD4+ T cell differentiation.
findings indicate that alpha4beta7*IgG can be used as a probe for functional MAdCAM-1 expressed on HEVs in GALT and could potentially serve as an anti-inflammatory drug inhibiting GALT-specific lymphocyte migration
Findings suggest that the inactive alpha4beta7 and alpha4beta7 activated by different stimuli have distinct conformations with different structural requirements for MAdCAM-1 binding.
The entry of recently activated CD4-expressing T cells into the bone marrow can occur in a transgenic beta1- and beta7-integrin-independent manner following Listeria monocytogenes infection.
mediates adhesion to mucosal addressin cell adhesion molecule-1 (MAdCAM-1)
M290 IEL antigen
, integrin beta-7
, integrin beta-P
, gut homing receptor beta subunit
, integrin beta 7 subunit