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the data suggest that CXCR3 and the integrin alpha4 mediate T cell recruitment to uninfected salivary glands but that redundant mechanisms mediate T cell recruitment after Murine Cytomegalovirus infection.
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As blockade of PI3Kgamma or integrin alpha4 prevents accumulation of myeloid-derived suppressor cells and reduces myeloid cell expression of immunosuppressive factors that stimulate tumor immune escape, these results highlight PI3Kgamma and integrin alpha4 as targets for the design of cancer therapeutics.
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integrin alpha4beta1 mediates the inhibitory effect of oncofetal Fibronectin both in vitro as well as in vivo.
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investigation of the role of alpha4 integrin and the therapeutic effect of HCA3551, a newly synthesized orally active small molecule alpha4 integrin antagonist, in the development of Theiler's murine encephalomyelitis virus-induced demyelinating disease
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AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.
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Here we delineated an inflammation-driven inhibitory mechanism of beige adipogenesis in obesity that required direct adhesive interactions between macrophages and adipocytes mediated by the integrin alpha4 and its counter-receptor VCAM-1, respectively; expression of the latter was upregulated in obesity.
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uncovered the importance of Itga4 for the generation of regulatory B cells in peripheral immune organs and their control of pathogenic T cell response and CNS pathology
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Macrophage tissue factor prothrombotic activity is regulated by integrin-alpha4/arf6 trafficking.
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this study shows that alpha4beta1 integrin mediates memory CD8+ T cells accumulation in salivary glands after infection with lymphocytic choriomeningitis virus
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The results uncovered a previously unknown role of integrin a4b7-MAdCAM-1 interactions as drivers of colitis by directing inflammatory monocytes into the colon.
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Integrin a4b7 is essential for suppression of experimental colitis as it regulates the colonic Treg cell population and innate immunity.
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These results suggest that Tie2 signaling induces alpha4beta1 integrin activation on bone marrow-mast cell progenitor for adhesion to VCAM-1.
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ITGA4 expression enhances metastasis in MYCN low neuroblastoma.
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investigated which alpha4beta1-integrin ligands expressed by endothelial cells are implicated
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Data indicate a role of integrin alpha4beta7 (alpha4beta7) in diet-induced atherosclerosis.
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CD49d-high-expressing Th1 memory phenotype CD4+ T cells with enhanced B cell helper activity develop early in the peritoneal cavity.
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Data suggest that bortezomib mobilizes hematopoietic stem cells (HSPCs) by modulation of the integrin alpha4beta1 (VLA)-4/vascular cell adhesion molecule-1 (VCAM-1) axis.
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Consistent with a role of alpha4beta7 in the generation of intestinal mononuclear phagocytes, bone marrow cells from beta7(-/-) mice poorly reconstituted small intestine retinoic acid (RA)-producing CD11c(hi) dendritic cells.
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alpha4 integrins whether deleted early or late have a dominant effect on bone marrow retention of erythroblasts and on terminal erythroid maturation at homeostasis and after stress.
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SP/drug efflux functionality of hematopoietic progenitors is controlled by mesenchymal niche through VLA-4/CD44 axis.
