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Dynamics characterization imparts that binding of long-chain octanol and DOG to pocket 2 or binding of sevoflurane to pocket 3 can induce a conformational displacement in arm 1 or 2, thus further opening the included angle and enlarging pocket 1, which can improve the pocket 1-PE affinity via an allosteric mechanism, consequently stimulating the PE-induced PKCdelta activation.
PKC-delta isoform plays a crucial role in Tat-TLR4 signaling pathway to activate NF-kappaB and CXCL8 production.
Tumor suppressor activity of Protein kinase C-delta.[review]
Protein kinase C acts as a tumor suppressor.Cancer-associated mutations in protein kinase C are generally loss-of-function mutations.[review]
Data suggest a targeted therapy and early medical intervention for protein kinase C delta (PKCdelta) could be a useful option for breast cancer cases complicated with type 2 diabetes mellitus (T2DM) or hyperglycemia.
NSC606985 produced a dose-dependent subcellular activation of PKCdelta. The dose-dependent dual action of NSC is mediated at least in part through the differential subcellular activation of castration-resistant prostate cancer (CRPC) LAPC4 cells.
PKC-delta expression is associated with KIT expression and the prognosis of patients with adenoid cystic carcinomas (AdCCs), suggesting that PKC-delta may be a potential therapeutic target for AdCCs.
Taken together, our findings suggest that TM-PKCdelta interaction may contribute to cardiovascular disorders by affecting monocye differentiation, which may develop future therapeutic applications.
PKC-delta played as a protective role in squamous cell carcinomas partly by down-regulating p63, leading to the suppression of squamous cell carcinomas cell proliferation
Activated PKCdelta interacts with the polymerase subunit PB2 and phospho-regulates NP oligomerization and RNP assembly during Influenza A virus infection.
NRF2 Ser40 phosphorylation was inhibited in Crif1-deficient bone marrow multipotent mesenchymal stromal cells even in the presence of three kinds of PKC agonists, suggesting that CRIF1 might co-activate PKC-delta to phosphorylate NRF2 Ser40.
PKCdelta has an overall negative influence on platelet function in response to collagen, while, following PAR stimulation, PKCdelta has a positive effect on platelet function. PKCdelta has different roles in platelet activation, aggregation and thrombus formation. Review.
Findings unveil a negative role for PKC-delta in cell-cell adhesion through phosphorylation of E-cadherin.
ADP inhibits mesothelioma cell proliferation via PKC-delta/JNK/p21/p27 signaling.
PKCdelta, via MAPK pathway, is involved in the glycodelin-driven cell differentiation.
PKCdelta is a critical regulator of signaling mechanisms of neutrophil-endothelium interaction in acute inflammation. Inhibition of PKCdelta in human endothelial cells and neutrophils reduced chemoattractant-induced neutrophil migration across TNF-alpha-activated endothelium, and reduced expression of E-selectin and ICAM-1. Shear rate and vascular geometry regulate the impact of PKCdelta inhibition of neutrophil-endot...
Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck-dependent activation of PKCdelta, which stimulates PKCgamma, resulting in translocation of phosphorylated p47(phox).
The interplay between intracellular progesterone receptor and PRKCA-PRKCD plays a key role in migration and invasion of human glioblastoma cells.
Amphiregulin enhances VEGF-A production in human chondrosarcoma cells and promotes angiogenesis by inhibiting miR-206 via FAK/c-Src/PKCdelta pathway.
In the present investigation, we demonstrated that miR486 is negatively associated with the expression of PKC-delta and could regulate the development of osteosarcoma. miR-486 may be a potential target for the treatment of osteosarcoma
GPx-1 knockout potentiated methamphetamine-induced cognitive deficits and alterations in phospho-ERK1/2 and phospho-PKCdelta expression.
High PKC delta expression is associated with pulmonary hypertension.
this study shows that PKCdelta is important for optimal macrophage killing effector functions and survival in mice with tuberculosis
These results suggest that CD40-activated CD40L reverse signalling has striking and opposite effects on the growth and elaboration of dendrites among major classes of brain neurons by PKC-dependent mechanisms.
Our key findings provide novel insights into the mechanism of action of heterotrimeric complex (PKCdelta-TIRAP-p38) in proinflammatory cytokine expression, which controls the development of the inflammatory trigger in stimulated macrophages.
sustained PKCdelta activation drives sustained microglial inflammatory responses and concomitant dopaminergic neurotoxicity consequently leading to neurobehavioral deficits
spinal PKCdelta has a role in the development of chronic pain in SCD, which may become a potential target for pharmacological interventions
K8/K18-dependent PKCdelta- and ASMase-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 loss.
MALAT1 recruits splice factor serine-arginine-rich splice factor 2 (SRSF2) to promote alternative splicing of PKCdeltaII.
SphK1 dependent PKC-delta activation plays an important role in promoting NF-kappaB activation and inflammatory response in acute liver failure, and inhibition of PKC-delta activation might be a potential therapeutic strategy for this disease.
PKCdelta activity exerts a dual role through the autophagy mechanism, decreasing proliferative capacity of mammary tumor cells but also regulating tumor stem cell self-renewal.
alpha(1)-AR activation is anti-apoptotic and protective during cardiac ischemia due to glucose deprivation and not hypoxia by enhancing glucose uptake into the heart via PKCdelta-mediated GLUT translocation that may be specific to the alpha(1A)-AR subtype.
Study shows that PRKCD influences corticotroph cell viability, POMC and ACTH expression suggesting that PRKCD plays an important role in restraining corticotroph cell proliferation and function.
PKCdelta-mediated phosphorylation of 14-3-3zeta contributes to the nuclear retention of FOXO1, even when FOXO1 is phosphorylated as under non-stress conditions
The homozygous Prkcqrpea1 and the null Prkcqtm1Litt mutants are reliable novel mouse models of RD and can also be used to study the effects of the disruption of PRKCQ (PKCtheta;) signaling in RPE cells.
function of protein kinase C delta (PKCdelta) during fertilization and embryonic development
A novel PKCdelta signaling pathway that requires retinol as a metabolic cofactor.
Data suggest that cytokines (TNF-alpha, IL1-beta, IFN-gamma) disrupt gap junction coupling in pancreatic islets under conditions associated with prediabetes; the mechanism appears to involve nitric oxide-mediated activation of protein kinase C-delta.
PKCdelta acts as a proapototic kinase in oxidized phospholipid-included apoptosis of RAW 264.7 macrophages.
Data show that protein kinase C delta (PKC-delta) knockout mice display atypical structural alterations at the articular cartilage and bone-cartilage interface.
Report PRKCD-dependent regulation of bovine embryonic development, gene expression and post-hatching events.
investigation of signaling mechanism used by fibroblast growth factor-2 (FGF2) to regulate interferon-tau (IFNT) production in trophoblasts: several lines of evidence suggest that FGF2 regulates IFNT production in trophoblasts by acting through PRKCD
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification
stimulation of bovine theca cells with lysophosphatidic acid leads to redistribution of protein kinase C delta from the cytosol to the perinuclear area and in the presence of LH, complete nuclear translocation of protein kinase C delta is induced
Protein kinase Cdelta-dependent phosphorylation of syndecan-4 regulates cell migration.
Activation of PKC induces the translocation of Nrf2 and the enhancement of endogenous antioxidant defenses in ischemic preconditioned rabbit heart.
PKC-delta mediates the apoptotic processes through ROS-dependent caspase-3 activation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.
protein kinase C delta VIII
, protein kinase C delta type
, tyrosine-protein kinase PRKCD
, protein kinase C delta variant IX
, protein kinase C, delta IV
, protein kinase C, delta V
, protein kinase C[d]
, protein kinase-delta2
, protein kinase C, delta
, protein kinase C delta type-like
, protein kinase C delta