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anti-Human DDX5 Anticorps:
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Human Polyclonal DDX5 Primary Antibody pour ICC, IF - ABIN152385
Muller, Hammond, Rio, Lee: An Efficient Method for Electroporation of Small Interfering RNAs into ENCODE Project Tier 1 GM12878 and K562 Cell Lines. dans Journal of biomolecular techniques : JBT 2015
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Cow (Bovine) Polyclonal DDX5 Primary Antibody pour WB - ABIN2775191
Guil, Gattoni, Carrascal, Abián, Stévenin, Bach-Elias: Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation. dans Molecular and cellular biology 2003
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Human Polyclonal DDX5 Primary Antibody pour EIA, WB - ABIN452908
Ong, Mittler, Mann: Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. dans Nature methods 2005
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Human Polyclonal DDX5 Primary Antibody pour EIA, WB - ABIN359623
Daub, Olsen, Bairlein, Gnad, Oppermann, Körner, Greff, Kéri, Stemmann, Mann: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. dans Molecular cell 2008
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Human Polyclonal DDX5 Primary Antibody pour ICC, IF - ABIN250198
Iggo, Gough, Xu, Lane, Spurr: Chromosome mapping of the human gene encoding the 68-kDa nuclear antigen (p68) by using the polymerase chain reaction. dans Proceedings of the National Academy of Sciences of the United States of America 1989
Human Polyclonal DDX5 Primary Antibody pour IF, WB - ABIN2566127
Lorgeoux, Pan, Le Duff, Liang: DDX17 promotes the production of infectious HIV-1 particles through modulating viral RNA packaging and translation frameshift. dans Virology 2013
This review affirms that DDX5 plays an indisputable role in human malignancies
The DDX5/Dbp2 subfamily of DEAD-box helicases act as chaperones for complexes formed by RNA molecules and proteins (RNP) in vivo.
our study demonstrated that MIAT was upregulated and may function as a ceRNA to increase DDX5 expression by sponging miR-141, which consequently contributed to GC growth and metastasis.
DDX5 played a crucial role in hepatocellular carcinoma proliferation and tumorigenesis
Data show that dual specificity phosphatase 5 (DUSP5) is a downstream target of p68 RNA helicase (p68).
RIP-seq analysis in HEK293T cells identifies a complete repertoire of DDX5/p68 interacting transcripts including LOC284454 lncRNA.
Results showed that DDX5 was significantly up-regulated in gastric cancer tissues and revealed a novel role of DDX5 in gastric cancer cell proliferation via the mTOR pathway.
DDX5 is shown to be involved in RNA metabolism and viral infection, especially for RNA virus which seems to hijack host DDX5 to facilitate its own replication. However, DDX5 exhibits a role in antiviral responses during HBV and MYXV infection. Its opposite roles between DNA and RNA infection likely reflect the different modes of the biosynthesis of RNA and DNA viruses. [review]
A significant overlap between hnRNPA1 and DDX5 splicing targets and they share many closely linked binding sites.
The role of DDX5 in regulating esophageal cancer cell proliferation and tumorigenesis.DDX5 is highly expressed in esophageal cancer.
Downregulation of p68 RNA Helicase (DDX5) Activates a Survival Pathway Involving mTOR and MDM2 Signals.(
Results show refined biochemical and biological comparison of yeast Dbp2 and human DDX5 enzymes. Human DDX5 possesses a 10-fold higher unwinding activity than Dbp2, partially due to the presence of a mammalian/avian specific C-terminal extension. Also, ectopic expression of DDX5 rescues the cold sensitivity, cryptic initiation defects, and impaired glucose import in dbp2Delta cells, suggesting functional conservation.
p53 gain-of-function mutations accelerate endometrial carcinoma progression and metastasis by interfering with Drosha and p68 binding and pri-miR-26a-1 processing, resulting in reduced miR-26a expression and EZH2 overexpression.
Cervical cancer cell DDX5 gene is transcriptionally upregulated by calcitriol through a VDRE located in its proximal promoter.
Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box DDX5 and DDX17 RNA Helicases
LMTK3 escapes tumour suppressor miRNAs via sequestration of DDX5.
The data provide a model in which p68 and p53 interplay regulates PLK1 expression, and which describes the behavior of these molecules, and the outcome of their interaction, in human breast cancer.
Results show that a new mechanism of oncogenesis is attributed to p68 by upregulation of AKT and consequent nuclear exclusion and degradation of tumor suppressor FOXO3a.
DDX5 played an important role in the proliferation and tumorigenesis of non-small-cell lung cancer cells by activating the beta-catenin signaling pathway.
study shows that correction of p68 may reduce toxicity of the mutant RNAs in DM1 and in DM2
Using an inducible knockout mouse model study reveals essential role for Ddx5 in spermatogonial maintenance and show that Ddx5 is indispensable for male fertility. Ddx5 regulates appropriate splicing of key genes necessary for spermatogenesis and can also act as a transcriptional co-activator. Ddx5 interacts with PLZF, a transcription factor required for germline maintenance, to co-regulate select target genes.
The results highlight a novel molecular mechanism underlying stability of neurogenesis-associated mRNAs controlled by the Klf4/Ddx5/Stau1 axis during mammalian corticogenesis.
Study provided strong evidence that mammalian DDX5 and S. cerevisiae Dbp2 are functionally conserved especially in cellular metabolism, despite enzymatic differences.
these results reveal important functions of DDX5 in regulating reprogramming and highlight the importance of a Ddx5-miR125b-Rybp axis in controlling cell fate.
DDX5 is a crucial factor involved in the complex transcriptional cascade of events that regulate adipogenesis and is essential for the initiation of adipogenesis.
Data indicate that Arf tumor suppressor blocks the functional interaction between c-Myc and p68 DEAD-box protein (DDX5).
Downregulation of DDX5 and DDX17 protein expression during myogenesis and epithelial-to-mesenchymal transdifferentiation contributes to the switching of splicing programs during these processes.
p68 levels may have an important role in influencing the decision between cell-cycle arrest and apoptosis in response to DNA damage.
our data demonstrate that Ddx5 and SRA function as coactivators of Notch signaling.
Data indicate that transcriptional coregulator ddx5/ddx17 RNA helicases can simultaneously regulate the transcriptional activity and alternative splicing of NFAT5 transcription factor.
Solution structures of the double-stranded RNA-binding domains from RNA helicase A.
study shows that mrhl RNA plays a negative role in Wnt signaling in mouse spermatogonial cells through its interaction with p68
The interaction between CDX2 transcription factor and DDX5 RNA helicase
DDX5 promotes the synthesis and maturation of rRNA, ultimately increasing ribosome output and proliferation. In Arf(-)cells, reduction of DDX5 was sufficient to impair RasV12-driven tumorigenesis.
DEAD-box RNA helicase p68 (DDX5) and its associated noncoding RNA, steroid receptor RNA activator (SRA), form a complex with CTCF that is essential for insulator function
Our experiments reveal that p68 shuttles via a classical RanGTPase-dependent pathway.
there is a tightly controlled expression and nucleolar localization of p68 in keratinocytes in vitro and during skin repair in vivo that functionally contributes to keratinocyte proliferation and gene expression
P68/DEAD box RNA helicase interacts directly with satellite DNAs in vitro and contacts between centromeres and P68 granules were observed during all phases of the cell cycle in vivo.
crosstalk between Runx2 and p68 controls osteoblast specification and maturation at multiple levels.
study reports age- and sex-specific interaction of estrogen receptor alpha-transactivation domain with p68 RNA helicase; age- and sex-specific interaction of p68 suggests its implication in ERalpha-mediated brain functions during aging
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.
ATP-dependent RNA helicase DDX5
, DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
, DEAD box protein 5
, DEAD box-5
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD)
, RNA helicase p68
, probable ATP-dependent RNA helicase DDX5
, D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 5
, DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 5
, DEAD box RNA helicase DEAD1
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5
, p68 RNA helicase
, ddx5 gene protein
, PCR product with interspecies-compatible primers
, putative ATP-dependent RNA helicase DDX5
, DEAD (Asp-Glu-Ala-Asp) box helicase 5
, DEAD-box helicase 5 L homeolog