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Human Polyclonal HDAC6 Primary Antibody pour IHC, WB - ABIN223301
Wang, Nguyen, McLaughlin, Sikkink, Ramirez-Alvarado, Weinshilboum: Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation. dans Proceedings of the National Academy of Sciences of the United States of America 2005
Show all 3 Pubmed References
Human Polyclonal HDAC6 Primary Antibody pour ChIP, WB - ABIN2668292
Ying, Zhang, Zhou, Qu, Wang, Liu, Lu, Zhu: Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB. dans PLoS ONE 2012
Show all 3 Pubmed References
Human Polyclonal HDAC6 Primary Antibody pour IHC (p), WB - ABIN387955
Hook, Orian, Cowley, Eisenman: Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. dans Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 6 Pubmed References
Human Polyclonal HDAC6 Primary Antibody pour ELISA - ABIN564313
Xargay-Torrent, López-Guerra, Saborit-Villarroya, Rosich, Campo, Roué, Colomer: Vorinostat-induced apoptosis in mantle cell lymphoma is mediated by acetylation of proapoptotic BH3-only gene promoters. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Human Monoclonal HDAC6 Primary Antibody pour ELISA, WB - ABIN564314
Bantscheff, Hopf, Savitski, Dittmann, Grandi, Michon, Schlegl, Abraham, Becher, Bergamini, Boesche, Delling, Dümpelfeld, Eberhard, Huthmacher, Mathieson, Poeckel, Reader, Strunk, Sweetman, Kruse et al.: Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. ... dans Nature biotechnology 2011
Human Polyclonal HDAC6 Primary Antibody pour ChIP, IP - ABIN4316760
Imbriano, Gurtner, Cocchiarella, Di Agostino, Basile, Gostissa, Dobbelstein, Del Sal, Piaggio, Mantovani: Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters. dans Molecular and cellular biology 2005
Human Monoclonal HDAC6 Primary Antibody pour FACS, ICC - ABIN4316769
Sirchia, Faversani, Rovina, Russo, Paganini, Savi, Augello, Rosso, Del Gobbo, Tabano, Bosari, Miozzo: Epigenetic effects of chromatin remodeling agents on organotypic cultures. dans Epigenomics 2016
that HDAC6 is associated physically with the chaperone protein dHsc4/Hsc70 to maintain the proteostasis of PLIN2 (Montrer PLIN2 Anticorps)
HDAC6 is necessary and sufficient for BRP (Montrer GDF5 Anticorps) deacetylation. HDAC6 promotes the formation of larger presynaptic densities.
Atrial fibrillation induces remodeling and loss of contractile function, at least in part through HDAC6 activation and subsequent derailment of alpha-tubulin (Montrer TUBA4A Anticorps) proteostasis and disruption of the cardiomyocyte microtubule structure.
From a genetic screen, we found that a histone deacetylase 6 (HDAC6) null mutation rescued tau-induced MT defects in both muscles and neurons.
Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X tremor ataxia syndrome.
Data suggest that alpha-synuclein inclusion formation in the presence of HDAC6 protects dopamine neurons from being damaged by oligomers, which may uncover a common mechanism for synucleinopathies.
findings suggest that it may be possible to intervene in neurodegeneration by augmenting HDAC6 to enhance autophagy
Findings indicate that HDAC6 facilitates degradation of potentially noxious protein substrates, contributing vitally to the neuroprotective role of autophagy.
Results suggest that atrophin recruits histone deacetylases 1 and 2 and G9a (Montrer EHMT2 Anticorps) to modify histone H3K9 and to determine cell fates.
Study detected evidence that recent strongly positive selection has been acting on a 2.7-kb region in an ancestral African population; this region overlaps with the 3' end of HDAC6, a gene that encodes a newly characterized stress surveillance factor.
Increased HDAC6 expression is associated with renal cell carcinoma (Montrer MOK Anticorps).
Our work shows that RanBPM, together with the CTLH complex, associates with HDAC6 and restricts cell migration through inhibition of HDAC6 activity. This study uncovers a novel function for the CTLH complex and suggests that it could have a tumour suppressive role in restricting HDAC6 oncogenic properties.
Results provide evidence that HDAC6 mediates the HIV-1 Tat (Montrer TAT Anticorps)-induced expression of chemokines by regulating reactive oxygen species-Nox2 (Montrer CYBB Anticorps)-based NADPH oxidase (Montrer NOX1 Anticorps) pathways in astrocytes. Furthermore, there is crosstalk between HDAC6 and NADPH oxidase (Montrer NOX1 Anticorps) in HIV-1 Tat (Montrer TAT Anticorps)-induced chemokine (Montrer CCL1 Anticorps) expression in astrocytes.
The development of this ACY-1215-resistant cell line has provided valuable insights into the mechanistic role of HDAC6 in lymphoma and offered a novel method to identify rational synergistic drug combinations.
rhTGF-beta1 affects sensitivity of human osteoblasts towards mechanical stimuli by damaging the microtubule structure of primary cilia in a HDAC6-dependent manner.
In conclusion, HDAC6 might enhance aggressive melanoma cells progression via interacting with PTPN1 (Montrer PTPN1 Anticorps), which was independent of its histone modifying activity.
Using motor neurons derived from induced pluripotent stem cells from patients with amyotrophic lateral sclerosis and FUS (Montrer FUS Anticorps) mutations, axonal transport defects could be successfully rescued by HDAC6 inhibitors or silencing HDAC6.
Data show that selective histone deacetylase 6 (HDAC6) inhibition or knockdown of HDAC6 expression was able to prevent caspase 3 (Montrer CASP3 Anticorps) activation in lung endothelial cells and maintain lung endothelial cell-cell junctions.
The HDAC6 Inhibitor Tubacin Induces Release of CD133(+) Extracellular Vesicles From Cancer Cells.
MicroRNA-22 Promoted Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Targeting HDAC6
Results link the aberrant GlyRS (Montrer GARS Anticorps)-HDAC6 interaction to Charcot-Marie-Tooth disease type 2D pathology and suggest HDAC6 as an effective therapeutic target.
3T3-L1 cells treated with the siRNA against HDAC6 reduced the autophagy level and enhanced collagen-induced cilia elongation, implying that HDAC6 was involved in mediating autophagy
identified that class II histone deacetylase 6 deacetylates and subsequently activates mDia2 (Montrer DIAPH3 Anticorps).
Study demonstrated that global Hdac6 knock-out mice show dopaminergic abnormalities. The behavioral and pharmacological analysis revealed that Hdac6 gene ablation results in an increased response of postsynaptic D2R (Montrer DRD2 Anticorps).
Findings provide physiological insight into the ciliary role of the CYLD (Montrer CYLD Anticorps)/HDAC6 axis and suggest a functional interplay between these two proteins in ciliary homeostasis.
Suppression of HDAC6 enhanced the interaction between HIF-1alpha (Montrer HIF1A Anticorps) and HSP70 (Montrer HSP70 Anticorps) under hypoxic conditions.
Overall, our results provide the first evidence that HDAC6 is capable of inducing expression of pro-inflammatory genes by regulating the ROS (Montrer ROS1 Anticorps)-MAPK (Montrer MAPK1 Anticorps)-NF-kappaB (Montrer NFKB1 Anticorps)/AP-1 (Montrer JUN Anticorps) pathways and serves as a molecular target for inflammation.
MAP3K4 (Montrer MAP3K4 Anticorps) activity controls epithelial-to-mesenchymal transition through the ubiquitination and degradation of HDAC6.
HDAC6 is a critical regulator of a pro-apoptotic p53 (Montrer TP53 Anticorps) K120 acetylation and mitochondrial function in mesenchymal stem cells
HDAC6 inhibition reduces cell growth primarily by reducing intracellular cAMP and Ca(2 (Montrer CA2 Anticorps)+) levels.
In coordination with increased HDAC6 phosphorylation, cigarette smoke extract inhibited Akt and activated glycogen synthase kinase (GSK)-3beta.
HDA6 is a general repressor of pathogen defence response and plays important roles in inhibiting and modulating the expression of pathogen-responsive genes in Arabidopsis.
The hda6 mutant showed a BR-repressed phenotype in the dark and was less sensitive to BR biosynthesis inhibitors. Genetic analysis indicated that HDA6 regulates BR signaling through BIN2. Furthermore, we identified K189 of BIN2 as an acetylated site, which can be deacetylated by HDA6 to influence BIN2 activity
The results suggest that HSI2 recruits MED13 (Montrer MED13 Anticorps) and HDA6 to suppress directly a subset of seed maturation genes post-germination.
HDA6 is a component of the TRB2 (Montrer TRIB2 Anticorps) complex.
Our results indicate that AtMBD6 is involved in RNA-mediated gene silencing and it binds to RNA binding proteins like AtRPS2C, AtAGO4 and AtNTF2. AtMBD6 also interacts with histone deacetylase AtHDA6 that might have a role in chromatin condensation at the targets of RdDM
HDA6 has at least two clearly separable activities in different genomic regions. In addition, we present an unexpected role for HDA6 in the control of DNA methylation (Montrer HELLS Anticorps) at CG dinucleotides.
Data show that both transcript levels and expression patterns of ENHANCER OF TRIPTYCHON AND CAPRICE1 (ETC1 (Montrer CD86 Anticorps)) in the root tip were affected in hda6 mutation.
HDC1 is a ubiquitously expressed nuclear protein (Montrer UBN1 Anticorps) that interacts with at least two deacetylases (HDA6 and HDA19), promotes histone deacetylation, and attenuates derepression of genes under water stress.
HDA6 and FLD (Montrer LPIN1 Anticorps) could act together in a protein complex. Increased levels of histone H3 acetylation and H3K4 trimethylation, indicating functional interplay between histone deacetylase and demethylase (Montrer MBD2 Anticorps) through HDA6 and FLD (Montrer LPIN1 Anticorps) interaction in flowering control.
Taken together, these data indicate that HDA6 is a part of the AS1 repressor complex to regulate the KNOX expression in leaf development.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
, histone deacetylase 6
, histone deacetylase HDA2
, histone deacetylase 5
, histone deacetylase mHDA2
, scurfy candidate 6