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TRAP80 is a selective regulator of hepatic lipogenesis and is required for LXR (Montrer NR1H3 Protéines)-dependent SREBP-1c (Montrer SREBF1 Protéines) activation.
Studies indicate that the activation domain of p53 (Montrer TP53 Protéines) (p53AD) binds directly to the MED17 subunit of Mediator, whereas the p53 (Montrer TP53 Protéines) C-terminal domain (p53CTD) binds the MED1 (Montrer MED1 Protéines) subunit.
the p. L371P mutation in MED17 is a founder mutation in the Caucasus Jewish community and that homozygosity for this mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination.
These results demonstrate that CK2 (Montrer CSNK2A1 Protéines)-mediated phosphorylation of Ser (Montrer SIGLEC1 Protéines)(53) in MED17 is required for the transcriptional activation of lipogenic genes in response to insulin (Montrer INS Protéines).
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
mediator of RNA polymerase II transcription subunit 17
, Mediator of RNA polymerase II transcription subunit 17
, CRSP complex subunit 6
, cofactor required for Sp1 transcriptional activation subunit 6
, cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa
, activator-recruited cofactor 77 kDa component
, thyroid hormone receptor-associated protein complex 80 kDa component
, transcriptional coactivator CRSP77
, vitamin D3 receptor-interacting protein complex 80 kDa component
, cofactor required for Sp1 transcriptional activation, subunit 6 (77kD)
, cofactor required for Sp1 transcriptional activation, subunit 6