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anti-Human NCOA1 Anticorps:
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Human Monoclonal NCOA1 Primary Antibody pour BI, WB - ABIN968842
Oñate, Tsai, Tsai, OMalley: Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. dans Science (New York, N.Y.) 1995
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Human Monoclonal NCOA1 Primary Antibody pour ChIP, IF - ABIN152353
Klinge, Jernigan, Mattingly, Risinger, Zhang: Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors alpha and beta by coactivators and corepressors. dans Journal of molecular endocrinology 2004
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Amphibian Polyclonal NCOA1 Primary Antibody pour FACS, ICC - ABIN152700
Rogatsky, Zarember, Yamamoto: Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones. dans The EMBO journal 2001
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Human Polyclonal NCOA1 Primary Antibody pour WB - ABIN151779
Heemers, Regan, Schmidt, Anderson, Ballman, Tindall: Androgen modulation of coregulator expression in prostate cancer cells. dans Molecular endocrinology (Baltimore, Md.) 2009
Our findings directly associate the AR/NCOA1 complex with PRKD1 (Montrer PRKD1 Anticorps) regulation and cellular migration and support the concept of therapeutic inhibition of NCOA1 in prostate cancer.
SRC-1 (Montrer SRC Anticorps) can impact osteoblast function in an estrogen receptor (Montrer ESR1 Anticorps)-independent manner.
The pregnane X receptor (Montrer NR1I2 Anticorps) down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 (Montrer SRC Anticorps) coactivator.
miR (Montrer MLXIP Anticorps)-4443 acts in a tumor-suppressive manner by down-regulating TRAF4 (Montrer TRAF4 Anticorps) and NCOA1 downstream of MEK (Montrer MAP2K1 Anticorps)-C/EBP (Montrer CEBPA Anticorps)-mediated leptin (Montrer LEP Anticorps) and insulin (Montrer INS Anticorps) signaling, and that insulin (Montrer INS Anticorps) and/or leptin (Montrer LEP Anticorps) resistance (e.g. in obesity) may suppress this pathway and increase the risk of metastatic CRC (Montrer CALR Anticorps).
Results provide the first evidence that NCOA1 is a direct target of miR (Montrer MLXIP Anticorps)-105-1 suggesting that NCOA1 and miR (Montrer MLXIP Anticorps)-105-1 may have potential prognostic value and may be useful as tumor biomarkers for the diagnosis of HCC (Montrer FAM126A Anticorps) patients.
Data suggest that steroid receptor (Montrer ESR2 Anticorps) coactivators (NCOA1, NCOA2 (Montrer NCOA2 Anticorps), NCOA3 (Montrer NCOA3 Anticorps)) are over-expressed in a number of hormone-dependent cancers where they promote tumor growth, invasion, metastasis, and chemo-resistance; with their multiple roles in cancer, steroid receptor (Montrer ESR2 Anticorps) coactivators are promising targets for development of antineoplastic agents that can interfere with their function. [REVIEW]
The mechanism of IL-6-induced AR activation is mediated through enhancing AR-SRC-1 interaction and inhibiting AR-SMRT interaction.
IL-6-mediated AR antagonism induced by cypermethrin is related to repress the recruitment of co-regulators SRC-1 and SMRT to the AR in a ligand-independent manner
NCOA1 potentiates breast cancer angiogenesis through upregulating HIF1alpha (Montrer HIF1A Anticorps) and AP-1 (Montrer FOSB Anticorps)-mediated VEGFa (Montrer VEGFA Anticorps) expression
miR (Montrer MLXIP Anticorps)-137 has a role in targeting p160 (Montrer MSH6 Anticorps) steroid receptor (Montrer ESR2 Anticorps) coactivators SRC1 (Montrer SRC Anticorps), SRC2 (Montrer NCOA2 Anticorps), and SRC3 (Montrer NCOA3 Anticorps) and inhibits cell proliferation
SRC-1 can impact osteoblast function in an estrogen receptor (Montrer ESR1 Anticorps)-independent manner.
The results suggest that biochanin A activates RORgamma-dependent IL-17 (Montrer IL17A Anticorps) transcription through the enhancement of STAT3 (Montrer STAT3 Anticorps) phosphorylation and STAT3 (Montrer STAT3 Anticorps)-mediated recruitment of NCOA1 to RORgamma.
ubiquitination of K446 limits RORgammat-mediated Th17 differentiation by inhibiting the recruitment of coactivator SRC1
Loss of SRC-1 is associated with high Blood Pressure and Aortic Stiffness.
local E2 inhibition could induce aberrant actin polymerization and also showed an important role of SRC-1 in the mediation of local E2 action on hippocampal synaptic plasticity by regulation of actin cytoskeleton dynamics
SRC-1/3 are required for cardiomyocyte proliferation and differentiation at earlier developmental stages, and their dysfunction causes NCC (Montrer SLC12A3 Anticorps)-like abnormalities in the hearts of newborn and adult mice.
While hippocampal SRC-1 was significantly downregulated by orchidectomy (ORX), its expression was rescued by treatment with testosterone in a dose-dependent manner. Testosterone regulates synaptic proteins involves AR, estrogen receptors and SRC-1.
fetal lungs produce signals to initiate labor when mature, and SRC-1/-2-dependent production of SP-A (Montrer SFTPA1 Anticorps) and PAF (Montrer KIAA0101 Anticorps) is crucial for this process
Consequently, SRC-1 null mice displayed low TAT (Montrer TAT Anticorps) expression and presented with hypertyrosinemia and corneal alterations, 2 clinical features observed in the human syndrome of TAT (Montrer TAT Anticorps) deficiency.
the effect of orchidectomy (ORX) on the expression of SRC-1
we cloned and sequenced full length cDNA of NCOA-1 gene in pig. The putative protein includes 1440 amino acids. Sequences alignment showed that pig NCOA-1 gene cDNA sequence has identity of 93.73% with human and mouse.
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified.
, PAX3/NCOA1 fusion protein
, class E basic helix-loop-helix protein 74
, renal carcinoma antigen NY-REN-52
, steroid receptor coactivator-1
, nuclear receptor coactivator 1
, steroid receptor coactivator 1
, nuclear receptor coactivator protein 1