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Human Monoclonal NCOA1 Primary Antibody pour ChIP, IF - ABIN152353
Klinge, Jernigan, Mattingly, Risinger, Zhang: Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors alpha and beta by coactivators and corepressors. dans Journal of molecular endocrinology 2004
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Human Polyclonal NCOA1 Primary Antibody pour ELISA, WB - ABIN537759
Haraguchi, Nishida, Ishidate, Akiyama: Activation of beta-catenin-TCF-mediated transcription by non-receptor tyrosine kinase v-Src. dans Biochemical and biophysical research communications 2004
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Human Polyclonal NCOA1 Primary Antibody pour IHC (p), ELISA - ABIN544393
Lopez, Carron, Ghysdael: v-SRC specifically regulates the nucleo-cytoplasmic delocalization of the major isoform of TEL (ETV6). dans The Journal of biological chemistry 2003
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Human Monoclonal NCOA1 Primary Antibody pour IHC (fro), IP - ABIN533014
Pene-Dumitrescu, Smithgall: Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner. dans The Journal of biological chemistry 2010
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Amphibian Polyclonal NCOA1 Primary Antibody pour FACS, ICC - ABIN152700
Rogatsky, Zarember, Yamamoto: Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones. dans The EMBO journal 2001
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Human Polyclonal NCOA1 Primary Antibody pour ELISA, WB - ABIN543932
Wang, Zhang, Nordeen, Shapiro: In vitro fluorescence anisotropy analysis of the interaction of full-length SRC1a with estrogen receptors alpha and beta supports an active displacement model for coregulator utilization. dans The Journal of biological chemistry 2007
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Human Polyclonal NCOA1 Primary Antibody pour WB - ABIN537970
Ardizzone, Zhan, Ander, Sharp: SRC kinase inhibition improves acute outcomes after experimental intracerebral hemorrhage. dans Stroke; a journal of cerebral circulation 2007
Human Polyclonal NCOA1 Primary Antibody pour WB - ABIN151779
Heemers, Regan, Schmidt, Anderson, Ballman, Tindall: Androgen modulation of coregulator expression in prostate cancer cells. dans Molecular endocrinology (Baltimore, Md.) 2009
FXR and RXR bind to the transcriptional coregulator steroid receptor coactivator 1 with higher affinity when they are part of the heterodimer complex than when they are in their respective monomeric states.
fifteen rare heterozygous variants in SRC-1 found in severely obese individuals impair leptin-mediated Pomc reporter activity in cells, whilst four variants found in non-obese controls do not
SRC-1 can partner with STAT1 independently of the estrogen receptor to initiate a transcriptional cascade and control regulation of key endocrine resistant genes in breast cancer.
NCOA1 interacts with NF-kappaB to increase VEGFC levels in human thyroid cancer.
Our findings directly associate the AR/NCOA1 complex with PRKD1 regulation and cellular migration and support the concept of therapeutic inhibition of NCOA1 in prostate cancer.
SRC-1 can impact osteoblast function in an estrogen receptor-independent manner.
The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator.
miR-4443 acts in a tumor-suppressive manner by down-regulating TRAF4 and NCOA1 downstream of MEK-C/EBP-mediated leptin and insulin signaling, and that insulin and/or leptin resistance (e.g. in obesity) may suppress this pathway and increase the risk of metastatic CRC.
Results provide the first evidence that NCOA1 is a direct target of miR-105-1 suggesting that NCOA1 and miR-105-1 may have potential prognostic value and may be useful as tumor biomarkers for the diagnosis of HCC patients.
Our study indicated that genotype and allele frequencies of rs79480871 showed strong associations with MM patients (pa = 3.5x10-4 and pa = 1.5x10-4), and the rs6457327 genotype was more readily associated with MM patients than with controls
Data suggest that steroid receptor coactivators (NCOA1, NCOA2, NCOA3) are over-expressed in a number of hormone-dependent cancers where they promote tumor growth, invasion, metastasis, and chemo-resistance; with their multiple roles in cancer, steroid receptor coactivators are promising targets for development of antineoplastic agents that can interfere with their function. [REVIEW]
The mechanism of IL-6-induced AR activation is mediated through enhancing AR-SRC-1 interaction and inhibiting AR-SMRT interaction.
IL-6-mediated AR antagonism induced by cypermethrin is related to repress the recruitment of co-regulators SRC-1 and SMRT to the AR in a ligand-independent manner
NCOA1 potentiates breast cancer angiogenesis through upregulating HIF1alpha and AP-1-mediated VEGFa expression
miR-137 has a role in targeting p160 steroid receptor coactivators SRC1, SRC2, and SRC3 and inhibits cell proliferation
Report novel PAX3-NCOA1 gene fusions in biphenotypic sinonasal sarcomas with focal rhabdomyoblastic differentiation.
Data indicate that finerenone inhibits mineralocorticoid receptor (MR), steroid receptor coactivator-1 binding at the regulatory sequence.
Data suggest that over-stimulating the steroid seceptor coactivators SRC-1, SRC-2, and SRC-3 oncogenic program can be an effective strategy to kill cancer cells.
Our study clearly demonstrated differentiation-dependant expression of SRC-1 and SRC-3 in chondrosarcoma
SRC-1 polymorphisms may be the underlying cause of coronary artery aneurysms in children with Kawasaki disease.
SRC-1 modulates the function of hypothalamic Pomc neurons
Sumoylation of RORgammaT regulates TH17 differentiation and thymocyte development via histone acetyltransferase KAT2A, which stabilizes the binding of SRC1 to enhance RORgammaT transcription factor activity.
Although the SRC-1 expression in female mice was lower than that in males under normal conditions, its expression in females was more dominant after spinal cord injury. The expression of Profilin-1 in both sexes increased first, and then decreased at 3 days after injury. However, there was a second increase in females at 7 days after injury.
The results suggest that biochanin A activates RORgamma-dependent IL-17 transcription through the enhancement of STAT3 phosphorylation and STAT3-mediated recruitment of NCOA1 to RORgamma.
ubiquitination of K446 limits RORgammat-mediated Th17 differentiation by inhibiting the recruitment of coactivator SRC1
Loss of SRC-1 is associated with high Blood Pressure and Aortic Stiffness.
local E2 inhibition could induce aberrant actin polymerization and also showed an important role of SRC-1 in the mediation of local E2 action on hippocampal synaptic plasticity by regulation of actin cytoskeleton dynamics
SRC-1/3 are required for cardiomyocyte proliferation and differentiation at earlier developmental stages, and their dysfunction causes NCC-like abnormalities in the hearts of newborn and adult mice.
While hippocampal SRC-1 was significantly downregulated by orchidectomy (ORX), its expression was rescued by treatment with testosterone in a dose-dependent manner. Testosterone regulates synaptic proteins involves AR, estrogen receptors and SRC-1.
fetal lungs produce signals to initiate labor when mature, and SRC-1/-2-dependent production of SP-A and PAF is crucial for this process
Consequently, SRC-1 null mice displayed low TAT expression and presented with hypertyrosinemia and corneal alterations, 2 clinical features observed in the human syndrome of TAT deficiency.
the effect of orchidectomy (ORX) on the expression of SRC-1
Letrozole induces dramatic decrease of SRC-1 in the medial septal, hippocampus, medial habenular nucleus, arcuate hypothalamic nucleus and superior colliculus.
SRC1 regulates anxiety responses in male and female mice.
IRS1 levels are significantly increased in mouse cell lines representing fat and muscle lineages with p/CIP and SRC-1 deletions and in white adipose tissue and skeletal muscle of knockout mice.
The effects of gonadectomy on the expression of SRC-1 suggest a distinct regulatory mode between female and male gonad hormones in the regulation of hippocampal SRC-1 protein.
A previously unidentified 70-kDa SRC-1 proteolytic isoform is highly elevated both in the endometriotic tissue of mice with endometriosis and in endometriotic stromal cells biopsied from patients with endometriosis.
Daidzein increases protein level of SRC-1 in cultured osteoblasts.
Localization and sex-difference of steroid receptor coactivator-1 immunoreactivities in the brain of adult female and male mice.
we cloned and sequenced full length cDNA of NCOA-1 gene in pig. The putative protein includes 1440 amino acids. Sequences alignment showed that pig NCOA-1 gene cDNA sequence has identity of 93.73% with human and mouse.
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified.
, PAX3/NCOA1 fusion protein
, class E basic helix-loop-helix protein 74
, renal carcinoma antigen NY-REN-52
, steroid receptor coactivator-1
, nuclear receptor coactivator 1
, steroid receptor coactivator 1
, nuclear receptor coactivator protein 1