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by performing protein profiling on isolated astrocytes we showed that an increase in astrocytic DJ-1 expression up-regulated a large group of proteins associated with redox regulation, inflammation and mitochondrial respiration. The majority of these proteins have also been shown to be regulated by Nrf2 (Montrer NFE2L2 Protéines).
Melatonin, added together with MPTP (Montrer PTPN2 Protéines) or added once MPTP (Montrer PTPN2 Protéines) was removed, prevented and recovered, respectively, the parkinsonian phenotype once it was established, restoring gene expression and normal function of the parkin (Montrer PARK2 Protéines)/PINK1 (Montrer PINK1 Protéines)/DJ-1/MUL1 loop and also the normal motor activity of the embryos.
These studies show that zDJ-1 is very similar to human DJ-1 and is evolutionarily conserved and expressed in dopaminergic neurons.
Results suggest that protein deglycase DJ-1 (DJ-1) plays a role in bone homeostasis in normal physiology and in bone-associated pathology by negatively regulating osteoclastogenesis.
Silencing the DJ-1 gene uncovers a link between mitochondria-associated Parkinson's disease and mitotic pressure.
Low DJ-1 expression impairs synaptic vesicle endocytosis and reavailability at nerve terminals.
DJ-1 deficiency causes defects in astrocyte-mediated repair of brain damage.
In cultured neurons and forebrain samples from Dj1(-/-) animals, there was chloride damage and a profound structural remodeling of the mitochondrial respiratory chain.
DJ-1 has a role in glutamate (Montrer GRIN1 Protéines) uptake into astrocytes by regulating flotillin-1 (Montrer FLOT1 Protéines) and caveolin-1 (Montrer CAV1 Protéines) expression
Network analysis reveals DJ-1/LDLR (Montrer LDLR Protéines) as common host proteins modulating pathogenesis of neurotropic viruses.
Induction of DJ-1 may serve as a novel regulator for hepatocellular carcinoma cell proliferation and HCC (Montrer FAM126A Protéines) development possibly through enhanced MAPK (Montrer MAPK1 Protéines) signaling and inflammation.
chaperone-mediated autophagy protects mitochondrial function by degrading nonfunctional PARK7 and maintaining its homeostasis, and dysregulation of this pathway may contribute to the neuronal stress and death in Parkinson disease pathogenesis
Knockdown of DJ-1 attenuates Nurr1 (Montrer NR4A2 Protéines) activity.
Low PARK7 expression is associated with pre-term birth.
The results suggest that the impaired mitochondrial activity could be due to the broken interaction between DJ-1 and NDUFS3 (Montrer NDUFS3 Protéines) and that downregulation of DJ-1 in sperm and testes contributes to AS pathogenesis.
In this review, we discuss the role as well as the underlying molecular mechanisms of DJ-1 in ocular diseases, including Fuchs endothelial corneal dystrophy (FECD (Montrer COL8a2 Protéines)), age-related macular degeneration (AMD (Montrer AMD1 Protéines)), cataracts, and ocular neurodegenerative diseases, highlighting that DJ-1 may serve as a very striking therapeutic target for ocular diseases.
Novel candidate genes of the PARK7 interactome play a role in MS.
DJ-1 promoter polymorphism is associated with male infertility.
The PD-associated L166P mutant, but not wild-type DJ-1, directly binds to and is cleaved by the mitochondrial serine protease Omi (Montrer HTRA2 Protéines) at both serine residues 3 and 121.
DJ-1 plays a major role in various signaling pathways. Related to its anti-oxidant properties, it mediates cell survival and proliferation by activating the extracellular signal-regulated kinase (ERK1/2) pathway and attenuates cell death signaling by inhibiting apoptosis signal-regulating kinase 1 (ASK1 (Montrer MAP3K5 Protéines)) activation. [review]
the present study highlighted the involvement of DJ1 in HGrelated EC injury and identified that DJ1 exerts a cellular protective effect in HUVECs exposed to HG induced oxidative stress via activation of the PI3K (Montrer PIK3CA Protéines)/AkteNOS signaling pathway.
These findings suggest that oxidation-induced ubiquitination and degradation can be a quality control mechanism of oxidized redox-sensitive proteins including Prxs and DJ-1.
study implies that DJ-1 may protect endothelial progenitor cells against Ang II (Montrer AGT Protéines)-induced dysfunction by activating the PPARgamma (Montrer PPARG Protéines)/HO-1 (Montrer HMOX1 Protéines).
The PARK7 gene was demonstrated to be located on porcine chromosome 6
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.
, parkinson disease protein 7 homolog
, protein DJ-1
, Parkinson disease 7
, RNA-binding protein regulatory subunit
, Parkinson disease (autosomal recessive, early onset) 7
, oncogene DJ1
, contraception-associated protein 1
, fertility protein SP22