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This study showed that AURKA (Montrer AURKA Protéines) inhibitors may provide a therapeutic strategy for biomarker-driven clinical studies to treat the NSCLCs harbouring SMARCA4/BRG1-inactivating mutations.
describe the approaches and methods used to identify SMARCA4 mutations, which drive development of the rare ovarian cancer, small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), and point to the broader relevance of this paradigm for future research in rare cancers.
Here, the authors show that C-terminally truncated forms of both SMARCA2 (Montrer SMARCA2 Protéines) and SMARCA4, produced by caspase (Montrer CASP3 Protéines)-mediated cleavage, accumulate in cells infected with different RNA or DNA viruses. The levels of truncated SMARCA2 (Montrer SMARCA2 Protéines) or SMARCA4 strongly correlate with the degree of cell damage and death observed after virus infection.
at genes where BRG1 and BRM (Montrer SMARCA2 Protéines) antagonize one another we observe a nearly complete rescue of gene expression changes in the combined BRG/BRM (Montrer SMARCA2 Protéines) double knockdown
Depletion of Brg1 improves the integrity of airway epithelium in asthma by regulating E-cadherin (Montrer CDH1 Protéines) expression in lung epithelial cells. Knockdown of Brg1 increased the cell proliferation and migration by human bronchial epithelial 16HBE cells.
High BRG1 expression is associated with leukemia and lymphoma.
HDAC9, in cooperation with BRG1 and MALAT1, mediates a critical epigenetic pathway responsible for vascular smooth muscle cells dysfunction.
SMARCA4-deficient thoracic sarcomas constitute a unique, highly lethal entity that requires full recognition and differentiation from other epithelioid malignancies involving the thoracic region.
The outcome following a diagnosis of any of these tumors is often poor, and the value of surveillance is unknown. International efforts to determine surveillance protocols are underway, and preliminary recommendations are made for carriers of SMARCB1 (Montrer SMARCB1 Protéines) and SMARCA4 mutations.
Study identified DNA methylation (Montrer HELLS Protéines) (DNAm) site, cg07786668 in ZFHX3 that is independently and significantly associated with myocardial infarction (MI) along with cg17218495 in SMARCA4. These results suggest that the development of MI might be influenced by changes in DNAm at these sites via a pathway that differs from that affected by cardiovascular disease-associated SNPs in these genes.
results suggest that miR (Montrer MLXIP Protéines)-144-3p contributes to OGD (Montrer FGFR1 Protéines)/R-induced neuronal injury in vitro through negatively regulating Brg1/Nrf2 (Montrer NFE2L2 Protéines)/ARE signaling.
Data found that Brg1 played important roles in hair cells (HCs (Montrer HLCS Protéines)) intrinsic polarity maintenance, anchoring outer hair cells base to the Deiter's cells and scar formation of the auditory epithelium. These results demonstrated a requirement for Brg1 activity in development and suggested a role for Brg1 in the proper cellular structure formation of HCs (Montrer HLCS Protéines).
The results demonstrated that restoration of Brg1 during reperfusion could enhance Nrf2 (Montrer NFE2L2 Protéines)-mediated inducible expression of HO-1 (Montrer HMOX1 Protéines) during hepatic ischemia-reperfusion injury to effectively increase antioxidant ability to combat against hepatocytes damage.
BAF (Montrer BANF1 Protéines) (BRG1/BRM (Montrer SMARCA2 Protéines)-Associated Factor) chromatin-remodeling complex may adaptively respond to ethanol exposure to protect against a complete loss of miR (Montrer MLXIP Protéines)-9-2 in fetal neural stem cells.
Chromatin accessibility at OCT4 (Montrer POU5F1 Protéines)-bound sites requires the chromatin remodeller BRG1, which is recruited to these sites by OCT4 (Montrer POU5F1 Protéines) to support additional transcription factor binding and expression of the pluripotency-associated transcriptome.
Data (including data from studies using knockout mice) suggest that Brg1 is phosphorylated by casein kinase 2 (Ck2 (Montrer CSNK2A1 Protéines); Ck2alpha1 and Ck2alpha-prime are catalytic subunits) in proliferating skeletal myoblasts; Brg1 is catalytic subunit of SWI (Montrer SMARCA1 Protéines)/SNF (Montrer SNRPA Protéines) chromatin-remodeling enzymes; Ck2 (Montrer CSNK2A1 Protéines)-mediated phosphorylation of Brg1 appears to regulate myoblast proliferation. (Brg1 = Brahma (Montrer SMARCA2 Protéines)-related gene 1 protein)
BRG1 is a SOX10 (Montrer SOX10 Protéines) co-activator, required to establish the melanocyte lineage and promote expression of genes important for melanocyte function.
n keratinocytes, the promoter-enhancer anchoring regions in the gene-rich transcriptionally active TADs are enriched for the binding of chromatin architectural proteins CTCF (Montrer CTCF Protéines), Rad21 (Montrer RAD21 Protéines) and chromatin remodeler Brg1. In contrast to gene-rich TADs, gene-poor TADs show preferential spatial contacts with each other, do not contain active enhancers and show decreased binding of CTCF (Montrer CTCF Protéines), Rad21 (Montrer RAD21 Protéines) and Brg1 in keratinocytes
Data demonstrate that Brg1 plays an essential role in development and homeostasis, including morphogenesis, stem cell differentiation and cell survival in the duodenum.
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4
, transcription activator BRG1-like
, ATP-dependent helicase SMARCA4
, BRG1-associated factor 190A
, BRM/SWI2-related gene 1
, SNF2-like 4
, brahma protein-like 1
, global transcription activator homologous sequence
, homeotic gene regulator
, mitotic growth and transcription activator
, nuclear protein GRB1
, protein BRG-1
, protein brahma homolog 1
, sucrose nonfermenting-like 4
, transcription activator BRG1
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
, SWI/SNF related transcriptional activator
, WI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4