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TRIM68 targets TFG, a novel regulator of IFN production, and in doing so turns off and limits type I IFN production in response to anti-viral detection systems
TRIM68 functions as a cofactor for AR-mediated transcription and is likely to be a novel diagnostic tool and a potentially therapeutic target for prostate cancer.
This gene encodes a protein which contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells.
E3 ubiquitin-protein ligase TRIM68
, Ro/SSA1 related protein
, SSA protein SS-56
, ring finger protein 137
, tripartite motif-containing 68
, tripartite motif-containing protein 68
, tripartite motif containing 68
, E3 ubiquitin-protein ligase TRIM68-like
, e3 ubiquitin-protein ligase TRIM68-like
, LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase TRIM68