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SensoLyte® AFC Urokinase (uPA) Activity Assay Kit

Act, FRET Fluorometric
N° du produit ABIN1882570
  • Antigène Voir toutes PLAU Kits
    PLAU (Plasminogen Activator, Urokinase (PLAU))
    Méthode de détection
    Fluorometric
    Application
    Activation (Act), Fluorescence Resonance Energy Transfer Microscopy (FRET)
    Marque
    SensoLyte®
    Attributs du produit
    The SensoLyte AFC Urokinase (uPA) Assay Kit is optimized for screening of enzyme inhibitors. This kit contains a fluorogenic substrate with a high reactivity and low background. uPA cleaves the substrate resulting in release of AFC (7-amino-4-trifluoromethylcoumarin) fluorophore. Fluorescence can be monitored at excitation /emission= 380/500 nm.
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  • Commentaires

    FRET-based Assay Kit

    Restrictions
    For Research Use only
  • Conseil sur la manipulation
    Aliquot as needed to avoid multiple freeze-thaw cycles. Protect Components A and B from light and moisture.
    Stock
    -80 °C
    Stockage commentaire
    Store all kit components, except Component D, at -20 °C. Store Component D at -80 °C. Components C can be stored at room temperature for convenience.
  • Antigène
    PLAU (Plasminogen Activator, Urokinase (PLAU))
    Autre désignation
    uPA (PLAU Produits)
    Synonymes
    PLAU Kit, u-PA Kit, ATF Kit, BDPLT5 Kit, QPD Kit, UPA Kit, URK Kit, uPA Kit, UPAM Kit, plasminogen activator, urokinase Kit, urokinase-type plasminogen activator Kit, PLAU Kit, CpipJ_CPIJ002131 Kit, CpipJ_CPIJ006543 Kit, CpipJ_CPIJ013396 Kit, CpipJ_CPIJ013623 Kit, Plau Kit
    Sujet
    Urokinase-type plasminogen activator (uPA) is a serine protease that functions in the conversion of the zymogen plasminogen to the active, broad-spectrum serine protease plasmin. Plasmin, in turn, mediates the pericellular proteolysis of extracellular matrix components and activates other proteases such as matrix metalloproteinases and collagenases that lead to the further degradation and remodeling of the extracellular matrix. Besides the proteolytic function, upon binding to uPA receptor (uPAR), uPA is involved in initiating versatile intracellular signal pathways that regulate cell proliferation, adhesion, and migration through its interaction with various integrins and vitronectin. uPA has been implicated in a number of normal and pathological processes, and recognized as a prognostic marker for various cancers as well as a target for drug discovery.
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