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COL18A1 Kit ELISA

COL18A1 Reactivité: Rat AA 1591-1774 Colorimetric Sandwich ELISA
N° du produit ABIN5510629
  • Antigène Voir toutes COL18A1 Kits ELISA
    COL18A1 (Collagen, Type XVIII, alpha 1 (COL18A1))
    Épitope
    AA 1591-1774
    Reactivité
    • 8
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat
    Méthode de détection
    Colorimetric
    Type de méthode
    Sandwich ELISA
    Application
    ELISA
    Fonction
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Rat Endostatin
    Marque
    PicoKine™
    Analytical Method
    Quantitative
    Specificité
    Expression system for standard: NSO
    Immunogen sequence: H1591-K1774
    Réactivité croisée (Details)
    There is no detectable cross-reactivity with other relevant proteins.
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  • Plaque
    Pre-coated
    Restrictions
    For Research Use only
  • Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    Date de péremption
    12 months
  • Antigène Voir toutes COL18A1 Kits ELISA
    COL18A1 (Collagen, Type XVIII, alpha 1 (COL18A1))
    Autre désignation
    Endostatin (COL18A1 Produits)
    Classe de substances
    Chemical
    Sujet

    Background: Endostatin is a naturally-occurring 20- kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin. And It is produced by proteolytic cleavage of collagen XVIII, a member of the multiplexin family that is characterized by interruptions in the triple helix creating multiple domains, by proteases such as cathepsins. Using a genomic clone as a probe for fluorescence in situ hybridization, Endostatin was mapped the COL18A1 gene to 21q22.3. By immunoprecipitation analysis using membrane fractions of human mammary epithelial cells, It showed that endostatin specifically bound to cell surface nucleolin with high affinity. Blockage of nucleolin with neutralizing antibody or knockdown of nucleolin by RNA interference countered the antiendothelial activity of endostatin and abrogated its antiangiogenic and antitumor activity in vivo.

    Synonyms: Collagen type XVIII, alpha (I) chain ,Col18a1 ,col18a1 ,

    Full Gene Name: collagen, type XVIII, alpha 1

    UniProt
    Q9WUW5
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