ACVRL1 Kit ELISA

N° du produit ABIN5510686

Détail du produit ACVRL1 Kit ELISA

Antigène: ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))

Épitope: AA 23-119

Reactivité: Souris

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse ALK-1/ACVRL1

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO
Immunogen sequence: D23-P119

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))

Autre désignation: Acvrl1 (ACVRL1 Produits)

Synonymes: ACVRL1 Kit ELISA, vgb Kit ELISA, alk1 Kit ELISA, zehn1109 Kit ELISA, hm:zehn1109 Kit ELISA, ACVRLK1 Kit ELISA, ALK-1 Kit ELISA, ALK1 Kit ELISA, HHT Kit ELISA, HHT2 Kit ELISA, ORW2 Kit ELISA, SKR3 Kit ELISA, TSR-I Kit ELISA, R-3 Kit ELISA, R3 Kit ELISA, SETHKIR Kit ELISA, AI115505 Kit ELISA, AI427544 Kit ELISA, Acvrlk1 Kit ELISA, Alk1 Kit ELISA, activin A receptor like type 1 Kit ELISA, activin A receptor type II-like 1 Kit ELISA, activin A receptor, type II-like 1 Kit ELISA, ACVRL1 Kit ELISA, acvrl1 Kit ELISA, Acvrl1 Kit ELISA

Sujet:

Protein Function: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. .

Background: Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ACVRL1 gene. It is also known as activin receptor-like kinase 1, or ALK1. This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

Synonyms: Serine/threonine-protein kinase receptor R3,SKR3,2.7.11.30,Activin receptor-like kinase 1,ALK-1,TGF-B superfamily receptor type I,TSR-I,Acvrl1,Acvrlk1, Alk-1,

Full Gene Name: Serine/threonine-protein kinase receptor R3

Cellular Localisation: Cell membrane, Single-pass type I membrane protein.

UniProt: Q61288