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ENPP2 Kit ELISA

ENPP2 Reactivité: Humain AA 36-863 Colorimetric Sandwich ELISA 625 pg/mL - 40000 pg/mL Cell Culture Supernatant, Milk, Plasma (heparin), Serum, Urine
N° du produit ABIN5692213
  • Antigène Voir toutes ENPP2 Kits ELISA
    ENPP2 (Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2))
    Épitope
    AA 36-863
    Reactivité
    • 3
    • 2
    • 1
    • 1
    Humain
    Méthode de détection
    Colorimetric
    Type de méthode
    Sandwich ELISA
    Gamme de detection
    625 pg/mL - 40000 pg/mL
    Seuil minimal de détection
    625 pg/mL
    Application
    ELISA
    Fonction
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Autotaxin. 96wells/kit, with removable strips.
    Marque
    PicoKine™
    Type d'échantillon
    Cell Culture Supernatant, Milk, Plasma (heparin), Serum, Urine
    Analytical Method
    Quantitative
    Specificité
    Expression system for standard: NSO, Immunogen sequence: A36-I863
    Sensibilité
    < 10 pg/mL
    Ingrédients
    96-well plate precoated with antibody
    lyophilized recombinant standard
    biotinylated antibody (dilution 1:100)
    Avidin-Biotin-Peroxidase Complex(ABC)(dilution 1:100)
    Sample diluent buffer
    Antibody diluent buffer
    ABC diluent buffer
    TMB color developing agent
    TMB stop solution
    Adhesive cover
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  • Durée du test
    15 min
    Plaque
    Pre-coated
    Restrictions
    For Research Use only
  • Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    Date de péremption
    12 months
  • Antigène Voir toutes ENPP2 Kits ELISA
    ENPP2 (Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2))
    Autre désignation
    ENPP2 (ENPP2 Produits)
    Synonymes
    ATX Kit ELISA, ATX-X Kit ELISA, AUTOTAXIN Kit ELISA, LysoPLD Kit ELISA, NPP2 Kit ELISA, PD-IALPHA Kit ELISA, PDNP2 Kit ELISA, Npps2 Kit ELISA, PD-Ialpha Kit ELISA, Pdnp2 Kit ELISA, MGC132047 Kit ELISA, atx Kit ELISA, zgc:63550 Kit ELISA, autotaxin Kit ELISA, enpp2 Kit ELISA, enpp2a Kit ELISA, enpp2b Kit ELISA, ectonucleotide pyrophosphatase/phosphodiesterase 2 Kit ELISA, ectonucleotide pyrophosphatase/phosphodiesterase 2 L homeolog Kit ELISA, ectonucleotide pyrophosphatase/phosphodiesterase 2 S homeolog Kit ELISA, ENPP2 Kit ELISA, Enpp2 Kit ELISA, enpp2 Kit ELISA, enpp2.L Kit ELISA, enpp2.S Kit ELISA
    Sujet

    Synonyms: Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, E-NPP 2, Autotaxin, Extracellular lysophospholipase D, LysoPLD, ENPP2, ATX, PDNP2

    Tissue Specificity: Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly expressed in peripheral tissues than in the central nervous system (CNS). Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues.

    Background: Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP 2), is an enzyme that in humans is encoded by the ENPP2 gene. The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.

    Cellular Localisation: Secreted.
    UniProt
    Q13822
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