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anti-Human APOB Anticorps:
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Human Polyclonal APOB Primary Antibody pour RID, WB - ABIN152417
Tsai, Hsu, Hsu, Lai, Chen, Shen, Huang, Chen, Lee, Tsai, Hsu, Wu, Huang, Shiao, Hsiao, Tsou: MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. dans The Journal of clinical investigation 2012
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Human Monoclonal APOB Primary Antibody pour ICC, FACS - ABIN968961
Peterson, Mack, Hall, Alsup, Alexander, Sully, Sawires, Cheung, Otto, Gresham: Apolipoprotein B Is an innate barrier against invasive Staphylococcus aureus infection. dans Cell host & microbe 2008
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Guinea Pig Polyclonal APOB Primary Antibody pour ID - ABIN2477467
Hazell, Arnold, Flowers, Waeg, Malle, Stocker: Presence of hypochlorite-modified proteins in human atherosclerotic lesions. dans The Journal of clinical investigation 1996
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Human Monoclonal APOB Primary Antibody pour RIA, ELISA - ABIN535615
Lin, Gordon, Wetterau: Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression. dans Journal of lipid research 1995
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Human Polyclonal APOB Primary Antibody pour IF (p), IHC (p) - ABIN872950
Choi, de Poot, Lee, Kim, Han, Kim, Finley, Lee: Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation. dans Nature communications 2016
Human Polyclonal APOB Primary Antibody pour IP, ELISA - ABIN2477466
Davidson, Appel, Doster, Baker, Brown: Diseases and parasites of red foxes, gray foxes, and coyotes from commercial sources selling to fox-chasing enclosures. dans Journal of wildlife diseases 1993
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Human Polyclonal APOB Primary Antibody pour ELISA, WB - ABIN449695
Benn, Nordestgaard, Jensen, Tybjaerg-Hansen: Polymorphisms in apolipoprotein B and risk of ischemic stroke. dans The Journal of clinical endocrinology and metabolism 2007
Human Polyclonal APOB Primary Antibody pour IHC (p), IP - ABIN267960
Bakillah, Tedla, Ayoub, John, Norin, Hussain, Brown: Plasma Nitration of High-Density and Low-Density Lipoproteins in Chronic Kidney Disease Patients Receiving Kidney Transplants. dans Mediators of inflammation 2015
Human Monoclonal APOB Primary Antibody pour FACS, IF - ABIN965573
Benn: Apolipoprotein B levels, APOB alleles, and risk of ischemic cardiovascular disease in the general population, a review. dans Atherosclerosis 2009
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Authors performed an analysis of public databases and literature for every variant published associated with FH, in the genes LDLR (Montrer LDLR Anticorps), APOB, and PCSK9 (Montrer PCSK9 Anticorps).
An increased apo (Montrer C9orf3 Anticorps) B/apo (Montrer C9orf3 Anticorps) A1 ratio was independently associated with all-cause mortality and cardiovascular events in peritoneal dialysis patients.
Targeted next generation DNA sequencing revealed several rare heterozygous missense variants in both MTTP (Montrer MTTP Anticorps) and APOB genes known or predicted to be deleterious, in addition to a novel heterozygous missense variant in SAR1B (Montrer SAR1B Anticorps), which encodes the gene causing chylomicron retention disease
Single nucleotide polymorphisms rs693 and rs6725189 of the apoB gene are associated with calcific aortic stenosis in Chinese subjects, in Xinjiang, China.
In conclusion, this study demonstrated that an APOB SNP, rs1042034, is closely associated with HCV infection through lipid metabolism alteration.
APOB rs11279109 is associated with increased risk of coronary heart disease in Kuwaiti population.
The simultaneous retention of fibrinogen and APOB-lipoproteins in FSD can be detected in routinely stained histological sections. The analysis of protein structures unraveled the pathomorphogenesis of this unexpected phenomenon. Fibrinogen gamma chain (Montrer FGG Anticorps) mutations provoke conformational changes in the region of the globular domain involved in the "end-to-end" interaction, thus impairing the D-dimer formation
APOB polymorphism rs679899 is associated with type 2 diabetes and glutamyl transpeptidase levels, while the LIPC polymorphism rs6083 may influence plasma lipid levels in Chinese Han population.
We present a case of homozygous familial defective apolipoprotein B-100 due to APOB R3500Q (rs5742904) treated with evolocumab ..Identification of a patient homozygous for familial defective apolipoprotein B-100(FDB) and successful treatment with PCSK9 (Montrer PCSK9 Anticorps) inhibition
Increased LDL levels were observed over time in patients with the -7673G>A polymorphism of the ApoB gene.
Type 2 diabetic, hyperlipidemic LDLr (Montrer LDLR Anticorps)(-/-)ApoB(100/100) mice show increased calcific aortic valve disease.
This study demonstrates that prevention of renal apoB accumulation is a mechanism by which TGF-beta (Montrer TGFB1 Anticorps) inhibition is nephroprotective.
Atorvastatin therapy did not show cholesterol-independent effects on inflammation in atherosclerotic lesions in Ldlr (Montrer LDLR Anticorps)(-/-)Apob(100/100) mice, whereas a cholesterol-lowering diet intervention was effective.
A peptide fragment of apoB-100 altered the immune-dominant epitope of CD8 (Montrer CD8A Anticorps)+ T cells and reduced atherosclerosis.
BI-1-mediated enhancement of ApoB secretion regulates hepatic lipid accumulation.
enhanced VLDL TG secretion in the absence of hepatocyte ABCA1 (Montrer ABCA1 Anticorps) is due to altered intracellular trafficking of apolipoprotein B (apoB), resulting in augmented TG addition to nascent VLDL.
We carried out our experiment in mice deficient in the low density lipoprotein (LDL) receptor (Montrer LDLR Anticorps) and expressing only ApoB100 molecule (ApoB - LDLr (Montrer LDLR Anticorps)) where the development of atherosclerosis is known to closely mimic human atherosclerosis
The effect of hypercholesterolemia induced immune response and inflammation on progression of atherosclerosis in ApoB(tm25gy) LDLr (Montrer LDLR Anticorps)(tm1Her) mice, expressing only ApoB100 and deficient in the low density lipoprotein receptor (Montrer LDLR Anticorps).
ApoB-containing lipoproteins contribute to augmentation of AngII-induced abdominal aortic aneurysms in male mice.
Immunization with human apolipoprotein B100 (ApoB) resulted in four-fold increased accumulation of effector T cells in ApoB-containing matrigel
The clinicopathological phenotype of affected Holstein cattle homozygous for the causative apolipoprotein B gene (APOB) mutation associated with cholesterol deficiency is described.
Beyond malabsorption of dietary lipids, deleterious effects of apolipoprotein B deficiency on hepatic lipid metabolism, steroid biosynthesis, and cell membrane function can be expected, which may result in unspecific symptoms of reduced fertility, growth, and health.
Cholesterol deficiency results from a 1.3kbp insertion of an endogenous retrovirus (ERV2-1-LTR_BT) into exon 5 of the APOB gene at BTA11:77,959kb. The insertion is flanked by 6bp target site duplications as described for insertions mediated by retroviral integrases.
A transposable element insertion in APOB causes cholesterol deficiency in Holstein cattle
Nonesterified fatty acids significantly inhibit the expression of ApoB100, ApoE (Montrer APOE Anticorps), MTP (Montrer MTTP Anticorps), and LDLR (Montrer LDLR Anticorps), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
after calving the apolipoprotein B(100) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP (Montrer MTTP Anticorps)) and apolipoprotein E (Montrer APOE Anticorps) messenger RNA abundance were higher in the liver.
found association between genotypes for LDLR (Montrer LDLR Anticorps) and APOB polymorphisms and serum lipid levels, but none of them seem to be the causal mutation but probably represent closely linked polymorphisms
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.
, apolipoprotein B (including Ag(x) antigen)
, apolipoprotein B-100
, apolipoprotein B48
, mutant Apo B 100
, apolipoprotein B PI
, apolipoprotein B-48
, apolipoprotein B