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anti-Human LDLRAP1 Anticorps:
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Human Monoclonal LDLRAP1 Primary Antibody pour IF, IHC (p) - ABIN565226
Quagliarini, Vallvé, Campagna, Alvaro, Fuentes-Jimenez, Sirinian, Meloni, Masana, Arca: Autosomal recessive hypercholesterolemia in Spanish kindred due to a large deletion in the ARH gene. dans Molecular genetics and metabolism 2007
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Human Polyclonal LDLRAP1 Primary Antibody pour ELISA, WB - ABIN249957
He, Gupta, Yi, Michaely, Hobbs, Cohen: ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2. dans The Journal of biological chemistry 2002
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Human Polyclonal LDLRAP1 Primary Antibody pour WB - ABIN631410
Holla, Strøm, Cameron, Berge, Leren: A chimeric LDL receptor containing the cytoplasmic domain of the transferrin receptor is degraded by PCSK9. dans Molecular genetics and metabolism 2010
LDLRAP1 associated with Familial Hypercholesterolemia and Polygenic Hypercholesterolemia in patients with Acute Coronary Syndrome , age =65 years, and LDL-C levels >/=160 mg/dl.
Numb (Montrer NUMB Anticorps) specifically regulates NPC1L1 (Montrer NPC1L1 Anticorps)-mediated cholesterol absorption both in human intestine and liver, distinct from ARH and Dab2 (Montrer DAB2 Anticorps), which selectively participate in LDLR (Montrer LDLR Anticorps)-mediated LDL uptake.
Identification of ARH gene and characterization of its mutations in Autosomal Recessive Hypercholesterolemia patients [Review]
cells that depend upon ARH for LDL uptake can control which lipoproteins are internalized by their LDLRs through changes in nitric oxide.
This work identified a combined LDL receptor (Montrer LDLR Anticorps) and LDLRAP1 mutation as the cause for severe familial hypercholesterolemia in a family of Turkish descent.
The report provides evidence that endocytosis of the ROMK potassium channel is controlled by LDLRAP1 (ARH). ROMK binds directly to the LDLRAP1, and this interaction is mediated by a novel variant of the canonical "NPXY" endocytotic signal, YxNPxFV. LDLRAP1-knockout mice are unable to physiologically regulate ROMK.
report the crystal structure at 1.37-A resolution of the phosphotyrosine-binding (PTB (Montrer PTBP1 Anticorps)) domain of ARH in complex with an LDLR (Montrer LDLR Anticorps) tail peptide containing the FxNPxY(0) internalization signal
LDL receptor (Montrer LDLR Anticorps)/LDLRAP1 double heterozygous mutations may account for severer phenotype in terms of xanthoma and atherosclerotic cardiovascular disease in familial hypercholesterolemia patients.
ARH protein is involved in cell cycle progression, possibly by affecting nuclear membrane formation through interaction with lamin B1 (Montrer LMNB1 Anticorps) or other mitotic proteins, and its absence affects cell proliferation and induces premature senescence.
Knockdown of ARH in polarized epithelial cells leads to specific apical missorting of truncated LDLR (Montrer LDLR Anticorps), which encodes only the FxNPxY motif (LDLR (Montrer LDLR Anticorps)-CT27 (Montrer CTCFL Anticorps)).
The combination of Arh and Dab2 (Montrer DAB2 Anticorps) is responsible for the majority of adaptor function in LDLR (Montrer LDLR Anticorps) endocytosis and LDLR (Montrer LDLR Anticorps)-mediated cholesterol homeostasis.
results are consistent with LDL receptor adaptor protein(ARH) playing a critical and specific role in low density lipoprotein receptor (Montrer LDLR Anticorps) endocytosis in the liver
Hepatocytes do not take-up LDL in vivo without ARH protein, but they normally catabolize LDL in vitro. Thus, the requirement of ARH protein for proper functioning of the LDLR (Montrer LDLR Anticorps) is not cell-specific, but rather may depend on the cellular environment.
the LDL receptor (Montrer LDLR Anticorps) alone can account for the clearance of apoE (Montrer APOE Anticorps)-containing lipoproteins in mice, and the contribution of other receptors is minimal, and b) defects in either increase the sensitivity to apoE (Montrer APOE Anticorps)-induced hypertriglyceridemia in mice.
Taken together, our data suggest that ARH is a multifunctional protein whose spectrum of function in the brain goes beyond the traditionally known metabolism of lipoproteins, and that ARH may be locally synthesized in the axon.
the endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis
Loss of gamma-secretase function decreased endocytosis of low-density lipoprotein (LDL) receptor (Montrer LDLR Anticorps)
ARH marks ROMK for clathrin-dependent endocytosis, in concert with the demands of potassium homeostasis
The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.
LDL receptor adaptor protein
, autosomal recessive hypercholesterolemia protein
, low density lipoprotein receptor adapter protein 1
, autosomal recessive hypercholesterolemia protein homolog
, low density lipoprotein receptor adaptor protein 1
, low-density lipoprotein adaptor protein
, ARH alpha
, autosomal recessive hypercholesterolemia protein homolog alpha
, low density lipoprotein receptor adapter protein 1-A
, phosphotyrosine binding protein
, phosphotyrosine-binding protein
, xARH alpha
, ARH beta
, autosomal recessive hypercholesterolemia protein homolog beta
, low density lipoprotein receptor adapter protein 1-B
, xARH beta