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The effects of the LIPC single nucleotide polymorphisms depended on sex, adiposity status, and triglyceride levels.
he LIPC rs2070895 polymorphism was found to be related to an increased risk of hypertension. However, LIPC rs1800588 polymorphism was not associated with the susceptibility to hypertension.
The study showed that LIPC rs493258 gene and haplotype containing the two minor alleles T-T in rs10468017-rs493258 may decrease age-related macular degeneration development.
The downregulation of LIPC in the HepG2 cells was associated with the decreased expression of CD133, decreased cell proliferation and colony formation, as well as increased resistance to chemotherapy.
APOB polymorphism rs679899 is associated with type 2 diabetes and glutamyl transpeptidase levels, while the LIPC polymorphism rs6083 may influence plasma lipid levels in Chinese Han population.
The expression of hHL promoted hepatic triglyceride accumulation and de novo lipogenesis without affecting triglyceride secretion, and this was associated with an upregulation of Srebf1 as well as the main genes controlling the synthesis of fatty acids. Transgenic mice also exhibited more adiposity and an increased LPL-mediated FFA influx into the WAT without affecting glucose tolerance
LPL is important for the maturation of small discoidal HDL particles into large spherical HDL particles, while HL is important for HDL remodeling of very large HDL particles into intermediate-size HDL particles, as shown in lipoprotein lipase and hepatic lipase deficiency
The expression level of LIPC, SLC16A8, and TIMP-3 was significantly associated with age-related macular degeneration pathology.
We found inverse independent correlations between metabolic clearance rate of insulin (MCRI) and hepatic lipase (P = 0.0004), insulin secretion (P = 0.0002), alanine aminotransferase (P = 0.0045), total fat mass (P = 0.014), and diabetes (P = 0.03). MCRI and apolipoprotein A-I exhibited a positive independent correlation (P = 0.035).
Hepatic lipase activity increases after levothyroxine therapy in subclincal hypothyroidism and can be interpreted as a possible explanation for the decrease in remnant-like lipoprotein cholesterol.
The hepatic lipase (LIPC) rs10468017 variant was associated with a significantly decreased risk of AMD
polymorphisms in HL protect HIV-infected patients from developing atherogenic dyslipidemia in a dose-dependent manner
the association between LIPC C-514T polymorphism, obesity and plasma lipid profile in Chinese children and adolescents, is reported.
results show that SM is a physiological inhibitor of HL activity in lipoproteins and that the specificity of the enzyme towards HDL is at least partly due to its low SM content.
The role of hepatic triglyceride lipase in remnant lipoprotein metabolism.
Several lipid-related gene polymorphisms interact with overweight/obesity to modulate blood pressure levels.
Dietary fat intake significantly modified the LIPC genetic effect on changes in serum triglyceride, LDL cholesterol, and HDL cholesterol concentrations during a 2-y randomized weight-loss intervention trial.
Hepatic lipase C-514T gene polymorphism is associated with cardiometabolic parameters and cardiovascular risk factors but not with fatty liver
there was no strong evidence to support an association between LIPC and HDCP in Han Chinese women. However, LIPC variants were associated with BMI, SBP, and lipid profiles in patients.
The present study suggested that the LIPC-514 C/T polymorphism of the HL gene has no significant association with the risk of endometriosis in the studied Iranian women.
The LIGHT (Tumour necrosis factor ligand superfamily member 14, TNFSF14)/Lymphotoxin beta-Receptor(LTbeta-R) pathway, which is involved in T-cell and macrophage activation, was diminished in plasma and in apoE-/-Irs2+/-HL-/- atheromas.
hepatic lipase KO mice had dyslipidemia including hypercholesterolemia, hypertriglyceridemia and increased non-esterified fatty acid levels. Also glucose intolerance, pancreatic and hepatic inflammation and steatosis.
Bone marrow (BM)-derived hepatic lipase mitigates the HDL-lowering, HDL-modulating, and cholesterol-raising effects of BM-derived cholesteryl ester transfer protein.
HL expressed by osteoblasts has an impact on osteoblast OPG expression and that lack of HL leads to increased bone mass.
Hepatic lipase and endothelial lipase influence molecular species of several classes of plasma lipids.
interaction of LIGHT with LTbetaR on hepatocytes, but not Kupffer cells, is sufficient to down regulate hepatic lipase expression and that this effect can be independent of LIGHT's costimulatory function.
Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties.
Data show a novel pathway involving HL hydrolysis of VLDL that activates PPARdelta through generation of specific monounsaturated fatty acids.
These results demonstrated that fatty acid synthase and hepatic lipase might be FXR-regulated genes in liver cells.
The additive effect of hepatic lipase and endothelial lipase on HDL metabolism but not macrophage reverse cholesterol transport in mice.
highly divergent effects of naturally occurring HL coding sequence variants on lipid and lipoprotein metabolism
HL deficiency protects against diet-induced obesity and its hepatic sequelae.
findings indicate that hepatic lipase is required for optimal reproductive performance
synthesized in peritoneal macrophages
indicate a role for hepatic lipase in clearing phospholipase/free cholesterol from the vesicular lipoproteins of phospholipid transfer protein knock out mice.
the determinants of cell surface binding exist within the carboxyl terminal 70 amino acids of hepatic lipase, of which the last five residues play an important role
Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice.
Not essential for diet-induced gallstone formation in mice.
hepatic lipase activity is influenced by epistatic interaction between two nonstructural loci on chromosomes 7 and 3
The results demonstrate that hepatic lipase deficiency, like LDLR deficiency, blunts the adrenal response to chronic ACTH stimulation and suggest a novel role for hepatic lipase in adrenal physiology.
LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake.
hepatic triacylglycerol lipase
, hepatic triglyceride lipase
, lipase, hepatic
, lipase C
, hepatic lipase
, hepatic triacylglycerol lipase-like
, lipase member C