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anti-Rat (Rattus) CEP72 Anticorps:
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Human Polyclonal CEP72 Primary Antibody pour IP, WB - ABIN253132
Stowe, Wilkinson, Iqbal, Stearns: The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium. dans Molecular biology of the cell 2012
Show all 2 Pubmed References
Human Polyclonal CEP72 Primary Antibody pour IHC, IHC (p) - ABIN4297753
Lüddecke, Ertych, Stenzinger, Weichert, Beissbarth, Dyczkowski, Gaedcke, Valerius, Braus, Kschischo, Bastians: The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability. dans Oncogene 2016
study proposes that Cep290 and Cep72 in centriolar satellites regulate the ciliary localization of BBS4, which in turn affects assembly and recruitment of the BBSome.
Concerning CEP72, our results are in line with the findings from the St Jude cohort of children treated for ALL with higher vincristine doses during chronic treatment. Larger high-throughput genetic analyses may be warranted to evaluate variants in other candidate genes such as CYP3A5 and reveal new nonpreviously reported alleles that may be peculiar to this region of the world
CEP72-ROS1 is a novel ROS1 fusion variant in non-small cell lung cancer (NSCLC) discovered by next-generation sequencing and could be included in ROS1 detection assay, such as reverse transcription PCR.
CEP72 represents a putative oncogene in colorectal cancer that might negatively regulate the mitotic function of BRCA1 to ensure chromosomal stability
The CEP72 polymorphism can identify adults at increased risk of vincristine-induced peripheral neuropathy
aim of this study was to determine whether the CEP72 rs924607 TT genotype is a useful marker of vincristine neuropathy during induction therapy among Spanish children with B-ALL treated on the LAL-SHOP protocols
In this study an inherited polymorphism in the promoter region of CEP72 was associated with increased risk and severity of vincristine-related peripheral neuropathy.
Findings show that Cep72 is the key protein essential for maintaining microtubule-organizing activity and structural integrity of the centrosome.
The product of this gene is a member of the leucine-rich-repeat (LRR) superfamily of proteins. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells.
centrosomal protein 72kDa
, centrosomal protein 72 kDa
, centrosomal protein 72-like
, centrosomal protein of 72 kDa-like
, centrosomal protein of 72 kDa